hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency
(2018)
Journal Article
Segeritz, C.-P., Rashid, S. T., de Brito, M. C., Serra, M. P., Ordonez, A., Morell, C. M., Kaserman, J. E., Madrigal, P., Hannan, N. R., Gatto, L., Tan, L., Wilson, A. A., Lilley, K., Marciniak, S. J., Gooptu, B., Lomas, D. A., & Vallier, L. (2018). hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency. Journal of Hepatology, 69(4), 851-860. https://doi.org/10.1016/j.jhep.2018.05.028
© 2018 The Authors Background & Aims: α1-Antitrypsin deficiency (A1ATD) is an autosomal recessive disorder caused by mutations in the SERPINA1 gene. Individuals with the Z variant (Gly342Lys) retain polymerised protein in the endoplasmic reticulum (E... Read More about hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency.