Outputs (2)

Gene activated reinforced scaffolds for SOX9 delivery to enhance repair of large load bearing articular cartilage defects (2024)
Journal Article
Joyce, M., Hodgkinson, T., Intini, C., Dixon, J. E., Kelly, D. J., & O’Brien, F. J. (2024). Gene activated reinforced scaffolds for SOX9 delivery to enhance repair of large load bearing articular cartilage defects. eCells and Materials Journal, 47, 91-108. https://doi.org/10.22203/eCM.v047a07

Articular cartilage (AC) has a poor capacity to repair once damaged, with progressive degeneration often leading to osteoarthritis (OA). While biomaterials fabricated with extra cellular matrix (ECM) native to the AC have shown promise for repair of... Read More about Gene activated reinforced scaffolds for SOX9 delivery to enhance repair of large load bearing articular cartilage defects.

Combined hydrogels that switch human pluripotent stem cells from self-renewal to differentiation (2014)
Journal Article
Dixon, J. E., Shah, D. A., Rogers, C., Hall, S., Weston, N., Parmenter, C. D., McNally, D., Denning, C., & Shakesheff, K. M. (2014). Combined hydrogels that switch human pluripotent stem cells from self-renewal to differentiation. Proceedings of the National Academy of Sciences, 111(15), 5580-5585. https://doi.org/10.1073/pnas.1319685111

The ability of materials to define the architecture and microenvironment experienced by cells provides new opportunities to direct the fate of human pluripotent stem cells (HPSCs) [Robinton DA, Daley GQ (2012) Nature 481(7381):295-305]. However, the... Read More about Combined hydrogels that switch human pluripotent stem cells from self-renewal to differentiation.