Outputs (188)

Mediterranean Diet Increases Endothelial Function in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (2020)
Journal Article
Shannon, O. M., Mendes, I., Köchl, C., Mazidi, M., Ashor, A. W., Rubele, S., …Siervo, M. (2020). Mediterranean Diet Increases Endothelial Function in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of Nutrition, 150(5), 1151–1159. https://doi.org/10.1093/jn/nxaa002

Background

The endothelium plays a key role in the maintenance of vascular health and represents a potential physiological target for dietary and other lifestyle interventions designed to reduce the risk of cardiovascular diseases (CVD) including... Read More about Mediterranean Diet Increases Endothelial Function in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Extracellular vesicles and asthma: A review of the literature (2020)
Journal Article
Sangaphunchai, P., Todd, I., & Fairclough, L. C. (2020). Extracellular vesicles and asthma: A review of the literature. Clinical and Experimental Allergy, 50(3), 291-307. https://doi.org/10.1111/cea.13562

© 2020 John Wiley & Sons Ltd Asthma is a chronic, recurrent and incurable allergy-related respiratory disease characterized by inflammation, bronchial hyperresponsiveness and narrowing of the airways. Extracellular vesicles (EVs) are a universal fe... Read More about Extracellular vesicles and asthma: A review of the literature.

Spatiotemporal regulation of GSK3β levels by miRNA-26a controls axon development in cortical neurons (2020)
Journal Article
Lucci, C., Mesquita-Ribeiro, R., Rathbone, A., & Dajas-Bailador, F. (2020). Spatiotemporal regulation of GSK3β levels by miRNA-26a controls axon development in cortical neurons. Development, 147(3), Article dev180232. https://doi.org/10.1242/dev.180232

© 2020. Published by The Company of Biologists Ltd. Both the establishment of neuronal polarity and axonal growth are crucial steps in the development of the nervous system. The local translation of mRNAs in the axon provides precise regulation of pr... Read More about Spatiotemporal regulation of GSK3β levels by miRNA-26a controls axon development in cortical neurons.

Setting the agenda for social science research on the human microbiome (2020)
Journal Article
Greenhough, B., Read, C. J., Lorimer, J., Lezaun, J., McLeod, C., Benezra, A., …Wills, J. (2020). Setting the agenda for social science research on the human microbiome. Palgrave Communications, 6(2020), Article 18

The human microbiome is an important emergent area of cross, multi and transdisciplinary study. The complexity of this topic leads to conflicting narratives and regulatory challenges. It raises questions about the benefits of its commercialisation an... Read More about Setting the agenda for social science research on the human microbiome.

The Evaluation and Use of a Food Frequency Questionnaire Among the Population in Trivandrum, South Kerala, India (2020)
Journal Article
Vijay, A., Mohan, L., Taylor, M. A., Grove, J. I., Valdes, A. M., Aithal, G. P., & Shenoy, K. T. (2020). The Evaluation and Use of a Food Frequency Questionnaire Among the Population in Trivandrum, South Kerala, India. Nutrients, 12(2), Article 383. https://doi.org/10.3390/nu12020383

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Dietary record tools such as food frequency questionnaire (FFQ) and food diaries (FD) are the most commonly used choices for assessing dietary intakes in most large-scale epidemiological studi... Read More about The Evaluation and Use of a Food Frequency Questionnaire Among the Population in Trivandrum, South Kerala, India.

Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism (2020)
Journal Article
Lane, J. R., Abramyan, A. M., Adhikari, P., Keen, A. C., Lee, K.-H., Sanchez, J., …Shi, L. (2020). Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism. eLife, 9, Article e52189. https://doi.org/10.7554/elife.52189

By analyzing and simulating inactive conformations of the highly-homologous dopamine D2 and D3 receptors (D2R and D3R), we find that eticlopride binds D2R in a pose very similar to that in the D3R/eticlopride structure but incompatible with the D2R/r... Read More about Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism.

Disruption of the Unique ABCG-Family NBD:NBD Interface Impacts Both Drug Transport and ATP Hydrolysis (2020)
Journal Article
Kapoor, P., Briggs, D. A., Cox, M. H., & Kerr, I. D. (2020). Disruption of the Unique ABCG-Family NBD:NBD Interface Impacts Both Drug Transport and ATP Hydrolysis. International Journal of Molecular Sciences, 21(3), Article 759. https://doi.org/10.3390/ijms21030759

ABCG2 is one of a triumvirate of human multidrug ATP binding cassette (ABC) transporters that are implicated in defense of cells and tissues against cytotoxic chemicals, but which can confer chemotherapy resistance states in oncology. Understanding t... Read More about Disruption of the Unique ABCG-Family NBD:NBD Interface Impacts Both Drug Transport and ATP Hydrolysis.

Real time monitoring of biofilm formation on coated medical devices for the reduction and interception of bacterial infections (2020)
Journal Article
Kurmoo, Y., Hook, A. L., Harvey, D., Dubern, J.-F., Williams, P., Morgan, S. P., …Alexander, M. R. (2020). Real time monitoring of biofilm formation on coated medical devices for the reduction and interception of bacterial infections. Biomaterials Science, 8(5), 1464-1477. https://doi.org/10.1039/c9bm00875f

Real time monitoring of bacterial attachment to medical devices provides opportunities to detect early biofilm formation and instigate appropriate interventions before infection develops. This study utilises long period grating (LPG) optical fibre se... Read More about Real time monitoring of biofilm formation on coated medical devices for the reduction and interception of bacterial infections.

Comparative Pro-cognitive and Neurochemical Profiles of Glycine Modulatory Site Agonists and Glycine Reuptake Inhibitors in the Rat: Potential Relevance to Cognitive Dysfunction and Its Management (2020)
Journal Article
Fone, K. C., Watson, D. J., Billiras, R. I., Sicard, D. I., Dekeyne, A., Rivet, J., …Millan, M. J. (2020). Comparative Pro-cognitive and Neurochemical Profiles of Glycine Modulatory Site Agonists and Glycine Reuptake Inhibitors in the Rat: Potential Relevance to Cognitive Dysfunction and Its Management. Molecular Neurobiology, 57, 2144–2166. https://doi.org/10.1007/s12035-020-01875-9

© 2020, The Author(s). Frontocortical NMDA receptors are pivotal in regulating cognition and mood, are hypofunctional in schizophrenia, and may contribute to autistic spectrum disorders. Despite extensive interest in agents potentiating activity at t... Read More about Comparative Pro-cognitive and Neurochemical Profiles of Glycine Modulatory Site Agonists and Glycine Reuptake Inhibitors in the Rat: Potential Relevance to Cognitive Dysfunction and Its Management.

Culture-enriched metagenomic sequencing enables in-depth profiling of the cystic fibrosis lung microbiota (2020)
Journal Article
Whelan, F. J., Waddell, B., Syed, S. A., Shekarriz, S., Rabin, H. R., Parkins, M. D., & Surette, M. G. (2020). Culture-enriched metagenomic sequencing enables in-depth profiling of the cystic fibrosis lung microbiota. Nature Microbiology, 5, 379-390. https://doi.org/10.1038/s41564-019-0643-y

Amplicon sequencing (for example, of the 16S rRNA gene) identifies the presence and relative abundance of microbial community members. However, metagenomic sequencing is needed to identify the genetic content and functional potential of a community.... Read More about Culture-enriched metagenomic sequencing enables in-depth profiling of the cystic fibrosis lung microbiota.