Outputs (212)

The endogenous cannabinoid anandamide increases human airway epithelial cell permeability through an arachidonic acid metabolite (2016)
Journal Article
Shang, V., O'Sullivan, S., Kendall, D., & Roberts, R. E. (2016). The endogenous cannabinoid anandamide increases human airway epithelial cell permeability through an arachidonic acid metabolite. Pharmacological Research, 105, https://doi.org/10.1016/j.phrs.2016.01.023

Injury to the bronchial epithelium in respiratory diseases such as asthma and COPD results in the lossof barrier function and an elevated sensitivity to environmental insults. An increased release of theendogenous cannabinoid, anandamide in response... Read More about The endogenous cannabinoid anandamide increases human airway epithelial cell permeability through an arachidonic acid metabolite.

Measurement of oxygen extraction fraction (OEF): An optimized BOLD signal model for use with hypercapnic and hyperoxic calibration (2016)
Journal Article
Merola, A., Murphy, K., Stone, A. J., Germuska, M. A., Griffeth, V. E., Blockley, N. P., …Wise, R. G. (2016). Measurement of oxygen extraction fraction (OEF): An optimized BOLD signal model for use with hypercapnic and hyperoxic calibration. NeuroImage, 129, 159-174. https://doi.org/10.1016/j.neuroimage.2016.01.021

© 2016 The Authors. Several techniques have been proposed to estimate relative changes in cerebral metabolic rate of oxygen consumption (CMRO2) by exploiting combined BOLD fMRI and cerebral blood flow data in conjunction with hypercapnic or hyperoxic... Read More about Measurement of oxygen extraction fraction (OEF): An optimized BOLD signal model for use with hypercapnic and hyperoxic calibration.

PlanHab: the combined and separate effects of 16 days of bed rest and normobaric hypoxic confinement on circulating lipids and indices of insulin sensitivity in healthy men (2016)
Journal Article
Simpson, E. J., Debevec, T., Eiken, O., Mekjavic, I., & Macdonald, I. (2016). PlanHab: the combined and separate effects of 16 days of bed rest and normobaric hypoxic confinement on circulating lipids and indices of insulin sensitivity in healthy men. Journal of Applied Physiology, 120(8), 947-955. doi:10.1152/japplphysiol.00897.2015

The roles of the zinc finger transcription factors XlnR, ClrA and ClrB in the breakdown of lignocellulose by Aspergillus niger (2016)
Journal Article
Raulo, R., Archer, D. B., & Kokolski, M. (2016). The roles of the zinc finger transcription factors XlnR, ClrA and ClrB in the breakdown of lignocellulose by Aspergillus niger. AMB Express, 6(5), https://doi.org/10.1186/s13568-016-0177-0

Genes encoding the key transcription factors (TF) XlnR, ClrA and ClrB were deleted from Aspergillus niger and the resulting strains were assessed for growth on glucose and wheat straw, transcription of genes encoding glycosyl hydrolases and saccharif... Read More about The roles of the zinc finger transcription factors XlnR, ClrA and ClrB in the breakdown of lignocellulose by Aspergillus niger.

Delivery strategies to control inflammatory response: Modulating M1–M2 polarization in tissue engineering applications (2016)
Journal Article
Alvarez, M. M., Liu, J. C., Trujillo-de Santiago, G., Cha, B. H., Vishwakarma, A., Ghaemmaghami, A. M., & Khademhosseini, A. (2016). Delivery strategies to control inflammatory response: Modulating M1–M2 polarization in tissue engineering applications. Journal of Controlled Release, 240, 349-363. https://doi.org/10.1016/j.jconrel.2016.01.026

Macrophages are key players in many physiological scenarios including tissue homeostasis. In response to injury, typically the balance between macrophage sub-populations shifts from an M1 phenotype (pro-inflammatory) to an M2 phenotype (anti-inflamma... Read More about Delivery strategies to control inflammatory response: Modulating M1–M2 polarization in tissue engineering applications.

Do crab spiders perceive Batesian mimicry in hoverflies? (2016)
Journal Article
Morris, R. L., & Reader, T. (2016). Do crab spiders perceive Batesian mimicry in hoverflies?. Behavioral Ecology, 27(3), 920-931. https://doi.org/10.1093/beheco/arv233

© 2015 The Author. Many putative Batesian mimics only approximately resemble their supposed models, and such "imperfect" mimics are readily distinguished from defended species by humans and other vertebrates. One explanation for the existence of impe... Read More about Do crab spiders perceive Batesian mimicry in hoverflies?.

Genome-wide methylation analysis identifies genes silenced in non-seminoma cell lines (2016)
Journal Article
Noor, D. A. M., Jeyapalan, J. N., Alhazmi, S., Carr, M., Squibb, B., Wallace, C., …Scotting, P. J. (2016). Genome-wide methylation analysis identifies genes silenced in non-seminoma cell lines. npj Genomic Medicine, 1(15009), https://doi.org/10.1038/npjgenmed.2015.9

Silencing of genes by DNA methylation is a common phenomenon in many types of cancer. However, the genome wide effect of DNA methylation on gene expression has been analysed in relatively few cancers. Germ cell tumours (GCTs) are a complex group of m... Read More about Genome-wide methylation analysis identifies genes silenced in non-seminoma cell lines.

A novel Bayesian approach to accounting for uncertainty in fMRI-derived estimates of cerebral oxygen metabolism fluctuations (2016)
Journal Article
Simon, A. B., Dubowitz, D. J., Blockley, N. P., & Buxton, R. B. (2016). A novel Bayesian approach to accounting for uncertainty in fMRI-derived estimates of cerebral oxygen metabolism fluctuations. NeuroImage, 129, 198-213. https://doi.org/10.1016/j.neuroimage.2016.01.001

Calibrated blood oxygenation level dependent (BOLD) imaging is a multimodal functional MRI technique designed to estimate changes in cerebral oxygen metabolism from measured changes in cerebral blood flow and the BOLD signal. This technique addresses... Read More about A novel Bayesian approach to accounting for uncertainty in fMRI-derived estimates of cerebral oxygen metabolism fluctuations.

Genomic analysis of serogroup Y Neisseria meningitidis isolates reveals extensive similarities between carriage and disease-associated organisms (2016)
Journal Article
Oldfield, N. J., Harrison, O. B., Bayliss, C. D., Maiden, M. C., Ala'Aldeen, D. A., & Turner, D. P. (2016). Genomic analysis of serogroup Y Neisseria meningitidis isolates reveals extensive similarities between carriage and disease-associated organisms. Journal of Infectious Diseases, 213(11), 1777-1785. https://doi.org/10.1093/infdis/jiw008

Background. Neisseria meningitidis is a frequent colonizer of the human nasopharynx with asymptomatic carriage providing the reservoir for invasive, disease-causing strains. Serogroup Y (MenY) strains are a major cause of meningococcal disease. High... Read More about Genomic analysis of serogroup Y Neisseria meningitidis isolates reveals extensive similarities between carriage and disease-associated organisms.

Relative Contribution of Intramyocellular Lipid to Whole-Body Fat Oxidation Is Reduced With Age but Subsarcolemmal Lipid Accumulation and Insulin Resistance Are Only Associated With Overweight Individuals (2016)
Journal Article
Chee, C., Shannon, C. E., Burns, A., Selby, A. L., Wilkinson, D., Smith, K., …Stephens, F. B. (2016). Relative Contribution of Intramyocellular Lipid to Whole-Body Fat Oxidation Is Reduced With Age but Subsarcolemmal Lipid Accumulation and Insulin Resistance Are Only Associated With Overweight Individuals. Diabetes, 65(4), 840-850. https://doi.org/10.2337/db15-1383

© 2016 by the American Diabetes Association. Insulin resistance is closely related to intramyocellular lipid (IMCL) accumulation, and both are associated with increasing age. It remains to be determined to what extent perturbations in IMCL metabolism... Read More about Relative Contribution of Intramyocellular Lipid to Whole-Body Fat Oxidation Is Reduced With Age but Subsarcolemmal Lipid Accumulation and Insulin Resistance Are Only Associated With Overweight Individuals.