Outputs (2)

Combined in vivo muscle mass, muscle protein synthesis and muscle protein breakdown measurement: a ‘Combined Oral Stable Isotope Assessment of Muscle (COSIAM)’ approach (2021)
Journal Article
Cegielski, J., Wilkinson, D. J., Brook, M. S., Boereboom, C., Phillips, B. E., Gladman, J. F. R., Smith, K., & Atherton, P. J. (2021). Combined in vivo muscle mass, muscle protein synthesis and muscle protein breakdown measurement: a ‘Combined Oral Stable Isotope Assessment of Muscle (COSIAM)’ approach. GeroScience, 43(6), 2653-2665. https://doi.org/10.1007/s11357-021-00386-2

Optimising approaches for measuring skeletal muscle mass and turnover that are widely applicable, minimally invasive and cost effective is crucial in furthering research into sarcopenia and cachexia. Traditional approaches for measurement of muscle p... Read More about Combined in vivo muscle mass, muscle protein synthesis and muscle protein breakdown measurement: a ‘Combined Oral Stable Isotope Assessment of Muscle (COSIAM)’ approach.

The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo (2020)
Journal Article
Bass, J. J., Kazi, A. A., Deane, C. S., Nakhuda, A., Ashcroft, S. P., Brook, M. S., Wilkinson, D. J., Phillips, B. E., Philp, A., Tarum, J., Kadi, F., Andersen, D., Garcia, A. M., Smith, K., Gallagher, I. J., Szewczyk, N. J., Cleasby, M. E., & Atherton, P. J. (2021). The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo. Journal of Physiology, 599(3), 963-979. https://doi.org/10.1113/JP280652

Key points: Reduced vitamin D receptor (VDR) expression prompts skeletal muscle atrophy. Atrophy occurs through catabolic processes, namely the induction of autophagy, while anabolism remains unchanged. In response to VDR-knockdown mitochondrial func... Read More about The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo.