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Outputs (4)

High performance liquid chromatography tandem mass spectrometry dual extraction method for identification of green tea catechin metabolites excreted in human urine (2014)
Journal Article
Clarke, K. A., Dew, T. P., Watson, R. E., Farrar, M. D., Bennett, S., Nicolaou, A., Rhodes, L. E., & Williamson, G. (2014). High performance liquid chromatography tandem mass spectrometry dual extraction method for identification of green tea catechin metabolites excreted in human urine. Journal of Chromatography B, 972, 29-37. https://doi.org/10.1016/j.jchromb.2014.09.035

The simultaneous analysis of free-form and conjugated flavonoids in the same sample is difficult but necessary to properly estimate their bioavailability. A method was developed to optimise the extraction of both free and conjugated forms of catechin... Read More about High performance liquid chromatography tandem mass spectrometry dual extraction method for identification of green tea catechin metabolites excreted in human urine.

Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation (2014)
Journal Article
Wightman, E. L., Reay, J. L., Haskell, C. F., Williamson, G., Dew, T. P., & Kennedy, D. O. (2014). Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation. British Journal of Nutrition, 112(2), 203-213. https://doi.org/10.1017/s0007114514000737

Previous research has shown that resveratrol can increase cerebral blood flow (CBF) in the absence of improved cognitive performance in healthy, young human subjects during the performance of cognitively demanding tasks. This lack of cognitive effect... Read More about Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation.

Urinary metabolite profiling identifies novel colonic metabolites and conjugates of phenolics in healthy volunteers (2014)
Journal Article
Pimpão, R. C., Dew, T., Figueira, M. E., McDougall, G. J., Stewart, D., Ferreira, R. B., Santos, C. N., & Williamson, G. (2014). Urinary metabolite profiling identifies novel colonic metabolites and conjugates of phenolics in healthy volunteers. Molecular Nutrition and Food Research, 58(7), 1414-1425. https://doi.org/10.1002/mnfr.201300822

Scope
The colonic metabolism of dietary flavonoids, phenolic acids and their phenolic metabolites is complex and many metabolites and conjugates have not yet been unambiguously identified in humans.

Methods and results
Urine samples from nine he... Read More about Urinary metabolite profiling identifies novel colonic metabolites and conjugates of phenolics in healthy volunteers.