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Professor HYWEL WILLIAMS's Outputs (185)

Quality and Reporting Completeness of Systematic Reviews and Meta-Analyses in Dermatology (2020)
Journal Article
Smires, S., Afach, S., Mazaud, C., Phan, C., Doval, I. G., Garcia Doval, I., Boyle, R., Dellavalle, R., Williams, H. C., Grindlay, D., Sbidian, E., & Le Cleach, L. (2021). Quality and Reporting Completeness of Systematic Reviews and Meta-Analyses in Dermatology. Journal of Investigative Dermatology, 141(1), 64-71. https://doi.org/10.1016/j.jid.2020.05.109

We sought to assess the quality of dermatological systematic reviews (SRs) and identify factors that predict high methodological quality. We searched for all SRs published in 2017 using PubMed, Epistemonikos, and the Cochrane Database of SRs. We incl... Read More about Quality and Reporting Completeness of Systematic Reviews and Meta-Analyses in Dermatology.

Two-by-two factorial randomised study within a trial (SWAT) to evaluate strategies for follow-up in a randomised prevention trial (2020)
Journal Article
Bradshaw, L., Montgomery, A. A., Williams, H. C., Chalmers, J., & Haines, R. (2020). Two-by-two factorial randomised study within a trial (SWAT) to evaluate strategies for follow-up in a randomised prevention trial. Trials, 21, Article 529. https://doi.org/10.1186/s13063-020-04373-4

Background
Failure to collect outcome data in randomised trials can result in bias and loss of statistical power. Further evaluations of strategies to increase retention are required. We assessed the effectiveness of two strategies for retention in... Read More about Two-by-two factorial randomised study within a trial (SWAT) to evaluate strategies for follow-up in a randomised prevention trial.

Prevention of Atopic Dermatitis (2020)
Journal Article
Williams, H. C., & Chalmers, J. (2020). Prevention of Atopic Dermatitis. Acta Dermato-Venereologica, 100, 380-388. https://doi.org/10.2340/00015555-3516

Despite advances in atopic dermatitis (AD) treatments, research into AD prevention has been slow. Systematic reviews of prevention strategies promoting exclusive and prolonged breastfeeding, or interventions that reduce ingested or airborne allergens... Read More about Prevention of Atopic Dermatitis.

Future of evidence ecosystem series: 3. From an evidence synthesis ecosystem to an evidence ecosystem (2020)
Journal Article
Craig, J. C., Ravaud, P., Créquit, P., Williams, H. C., Meerpohl, J., & Boutron, I. (2020). Future of evidence ecosystem series: 3. From an evidence synthesis ecosystem to an evidence ecosystem. Journal of Clinical Epidemiology, 123, 153-161. https://doi.org/10.1016/j.jclinepi.2020.01.027

The “one-off” approach of systematic reviews is no longer sustainable; we need to move toward producing “living” evidence syntheses (i.e., comprehensive, based on rigorous methods, and up-to-date). This implies rethinking the evidence synthesis ecosy... Read More about Future of evidence ecosystem series: 3. From an evidence synthesis ecosystem to an evidence ecosystem.

Future of evidence ecosystem series: 2. Current opportunities and need for better tools and methods (2020)
Journal Article
Créquit, P., Boutron, I., Meerpohl, J., Williams, H., Craig, J., & Ravaud, P. (2020). Future of evidence ecosystem series: 2. Current opportunities and need for better tools and methods. Journal of Clinical Epidemiology, 123, 143-152. https://doi.org/10.1016/j.jclinepi.2020.01.023

To become user-driven and more useful for decision-making, the current evidence synthesis ecosystem requires significant changes (Paper 1.Future of evidence ecosystem series). Reviewers have access to new sources of data (clinical trial registries, p... Read More about Future of evidence ecosystem series: 2. Current opportunities and need for better tools and methods.

Future of evidence ecosystem series: 1. Introduction — Evidence synthesis ecosystem needs dramatic change (2020)
Journal Article
Craig, J. C., Boutron, I., Créquit, P., Williams, H., Meerpohl, J., Craig, J. C., & Ravaud, P. (2020). Future of evidence ecosystem series: 1. Introduction — Evidence synthesis ecosystem needs dramatic change. Journal of Clinical Epidemiology, 123, 135-142. https://doi.org/10.1016/j.jclinepi.2020.01.024

To make healthcare decisions, patients, clinicians, clinical practice guideline developers, researchers, policy-makers and health system managers need a comprehensive, critical, accessible, actionable and up-to-date synthesis of all available evidenc... Read More about Future of evidence ecosystem series: 1. Introduction — Evidence synthesis ecosystem needs dramatic change.

Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial (2020)
Journal Article
Chalmers, J. R., Haines, R. H., Bradshaw, L. E., Montgomery, A. A., Thomas, K. S., Brown, S. J., Ridd, M. J., Lawton, S., Simpson, E. L., Cork, M. J., Sach, T. H., Flohr, C., Mitchell, E. J., Swinden, R., Tarr, S., Davies-Jones, S., Jay, N., Kelleher, M., Perkin, M. R., Boyle, R. J., & Williams, H. C. (2020). Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial. Lancet, 395(10228), 962-972. https://doi.org/10.1016/S0140-6736%2819%2932984-8

Background

Skin barrier dysfunction precedes eczema development. We tested whether daily use of emollient in the first year could prevent eczema in high-risk children.

Methods

We did a multicentre, pragmatic, parallel-group, randomised contr... Read More about Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial.

An algorithm for diagnosing IgE-mediated food allergy in study participants who do not undergo food challenge (2020)
Journal Article
Kelleher, M. M., Montgomery, A. A., Jay, N., Perkin, M. R., Haines, R. H., Batt, R., Chalmers, J. R., Bradshaw, L. E., Williams, H. C., & Boyle, R. J. (2020). An algorithm for diagnosing IgE-mediated food allergy in study participants who do not undergo food challenge. Clinical and Experimental Allergy, 50(3), 334-342. https://doi.org/10.1111/cea.13577

© 2020 The Authors. Clinical & Experimental Allergy published by John Wiley & Sons Ltd. Background: Food allergy diagnosis in clinical studies can be challenging. Oral food challenges (OFC) are time-consuming, carry some risk and may, therefore,... Read More about An algorithm for diagnosing IgE-mediated food allergy in study participants who do not undergo food challenge.

Algorithm based smartphone apps to assess risk of skin cancer in adults: systematic review of diagnostic accuracy studies (2020)
Journal Article
Dinnes, J., Freeman, K., Chuchu, N., Takwoingi, Y., Bayliss, S. E., Matin, R. N., Jain, A., Walter, F. M., Williams, H. C., & Deeks, J. J. (2020). Algorithm based smartphone apps to assess risk of skin cancer in adults: systematic review of diagnostic accuracy studies. BMJ, 368, Article m127. https://doi.org/10.1136/bmj.m127

© Published by the BMJ Publishing Group Limited. Objective To examine the validity and findings of studies that examine the accuracy of algorithm based smartphone applications ("apps") to assess risk of skin cancer in suspicious skin lesions. Design... Read More about Algorithm based smartphone apps to assess risk of skin cancer in adults: systematic review of diagnostic accuracy studies.

A behaviour change package to prevent hand dermatitis in nurse working in the National Health Service: results of a cluster randomised controlled trial (2020)
Journal Article
Madan, I., Parsons, V., Ntani, G., Coggon, D., Wright, A., English, J., McCrone, P., Smedley, J., Rushton, L., Murphy, C., Cookson, B., & Williams, H. C. (2020). A behaviour change package to prevent hand dermatitis in nurse working in the National Health Service: results of a cluster randomised controlled trial. British Journal of Dermatology, 183(3), 462-470. https://doi.org/10.1111/bjd.18862

Background
Occupational hand dermatitis poses a serious risk for nurses.

Objectives
To evaluate the clinical and cost‐effectiveness of a complex intervention in reducing the prevalence of hand dermatitis in nurses

Trial design
Cluster random... Read More about A behaviour change package to prevent hand dermatitis in nurse working in the National Health Service: results of a cluster randomised controlled trial.

Measuring atopic eczema symptoms in clinical practice: The first consensus statement from the Harmonising Outcome Measures for Eczema in clinical practice initiative (2020)
Journal Article
Leshem, Y. A., Chalmers, J. R., Apfelbacher, C., Furue, M., Gerbens, L. A., Prinsen, C. A., Schmitt, J., Spuls, P. I., Thomas, K. S., Williams, H. C., & Simpson, E. L. (2020). Measuring atopic eczema symptoms in clinical practice: The first consensus statement from the Harmonising Outcome Measures for Eczema in clinical practice initiative. Journal of The American Academy of Dermatology, 82(5), 1181-1186. https://doi.org/10.1016/j.jaad.2019.12.055

Background: Measuring patient-centered outcomes in clinical practice is valuable for monitoring patients and advancing real-world research. A new initiative from the Harmonising Outcome Measures for Eczema (HOME) group aims to recommend what might be... Read More about Measuring atopic eczema symptoms in clinical practice: The first consensus statement from the Harmonising Outcome Measures for Eczema in clinical practice initiative.

Best emollients for eczema (BEE) – comparing four types of emollients in children with eczema: protocol for randomised trial and nested qualitative study (2019)
Journal Article
Ridd, M. J., Wells, S., Edwards, L., Santer, M., MacNeill, S., Sanderson, E., Sutton, E., Shaw, A. R., Banks, J., Garfield, K., Roberts, A., Barrett, T. J., Baxter, H., Taylor, J., Lane, J. A., Hay, A. D., Williams, H. C., & Thomas, K. S. (2019). Best emollients for eczema (BEE) – comparing four types of emollients in children with eczema: protocol for randomised trial and nested qualitative study. BMJ Open, 9(11), Article e033387. https://doi.org/10.1136/bmjopen-2019-033387

Introduction Atopic dermatitis/eczema affects around 20% of children and is characterised by inflamed, dry, itchy skin. Guidelines recommend ‘leave-on’ emollients that are applied directly to the skin to add or trap moisture and used regularly, they... Read More about Best emollients for eczema (BEE) – comparing four types of emollients in children with eczema: protocol for randomised trial and nested qualitative study.

A behaviour change package to prevent hand dermatitis in nurses working in health care: the SCIN cluster RCT (2019)
Journal Article
Madan, I., Parsons, V., Ntani, G., Wright, A., English, J., Coggon, D., McCrone, P., Smedley, J., Rushton, L., Murphy, C., Cookson, B., Lavender, T., & Williams, H. (2019). A behaviour change package to prevent hand dermatitis in nurses working in health care: the SCIN cluster RCT. Health Technology Assessment, 23(58), 1-92. https://doi.org/10.3310/hta23580

BACKGROUND: Although strategies have been developed to minimise the risk of occupational hand dermatitis in nurses, their clinical effectiveness and cost-effectiveness remain unclear. OBJECTIVES: The Skin Care Intervention in Nurses trial tested the... Read More about A behaviour change package to prevent hand dermatitis in nurses working in health care: the SCIN cluster RCT.

Interventions to reduce Staphylococcus aureus in the management of eczema (2019)
Journal Article
George, S. M., Karanovic, S., Harrison, D. A., Rani, A., Birnie, A. J., Bath-Hextall, F. J., Ravenscroft, J. C., & Williams, H. C. (2019). Interventions to reduce Staphylococcus aureus in the management of eczema. Cochrane Database of Systematic Reviews, 2019(10), 145. https://doi.org/10.1002/14651858.cd003871.pub3

© 2019 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. Background Staphylococcus aureus (S. aureus) can cause secondary infection in eczema, and may promote inflammation in eczema that does not look infected. There is no standard i... Read More about Interventions to reduce Staphylococcus aureus in the management of eczema.

Dermatofibrosarcoma Protuberans Re-excision and Recurrence Rates in the Netherlands Between 1989 and 2016 (2019)
Journal Article
van Lee, C. B., Kan, W. C., Gran, S., Mooyaart, A., Mureau, M. A., Williams, H., Matin, R., van den Bos, R., & Hollestein, L. M. (2019). Dermatofibrosarcoma Protuberans Re-excision and Recurrence Rates in the Netherlands Between 1989 and 2016. Acta Dermato-Venereologica, 99(12), 1160-1165. https://doi.org/10.2340/00015555-3287

Dermatofibrosarcoma protuberans is a rare soft tissue tumour with a very low (less than 0.5%) rate of metastasis. Rates of re-excision and recurrence were determined using data from the Netherlands Cancer Registry between 1989 and 2016. Of the 1,890... Read More about Dermatofibrosarcoma Protuberans Re-excision and Recurrence Rates in the Netherlands Between 1989 and 2016.

Ultrasound, CT, MRI, or PET-CT for staging and re-staging of adults with cutaneous melanoma (2019)
Journal Article
Dinnes, J., Ferrante Di Ruffano, L., Takwoingi, Y., Cheung, S. T., Nathan, P., Matin, R. N., Chuchu, N., Chan, S. A., Durack, A., Bayliss, S. E., Gulati, A., Patel, L., Davenport, C., Godfrey, K., Subesinghe, M., Traill, Z., Deeks, J. J., & Williams, H. C. (2019). Ultrasound, CT, MRI, or PET-CT for staging and re-staging of adults with cutaneous melanoma. Cochrane Database of Systematic Reviews, 2019(7), Article CD012806. https://doi.org/10.1002/14651858.CD012806.pub2

© 2019 The Cochrane Collaboration. Background Melanoma is one of the most aggressive forms of skin cancer, with the potential to metastasise to other parts of the body via the lymphatic system and the bloodstream. Melanoma accounts for a small percen... Read More about Ultrasound, CT, MRI, or PET-CT for staging and re-staging of adults with cutaneous melanoma.

Clinical onset of atopic eczema: results from two nationally representative British birth cohorts followed through mid-life (2019)
Journal Article
Abubara, K., Ye, M., McCulloch, C. E., Sullivan, A., Margolis, D. J., Strachan, D. P., Paternoster, L., Yew, Y. W., Williams, H. C., & Langan, S. M. (2019). Clinical onset of atopic eczema: results from two nationally representative British birth cohorts followed through mid-life. Journal of Allergy and Clinical Immunology, 144(3), 710–719. https://doi.org/10.1016/j.jaci.2019.05.040

Background
Atopic eczema onset is described primarily in early childhood; the frequency and characteristics of adult-onset disease remain controversial.
Objective
To determine the proportion of individuals who report atopic eczema symptoms between... Read More about Clinical onset of atopic eczema: results from two nationally representative British birth cohorts followed through mid-life.

Different strategies for using topical corticosteroids in people with eczema (2019)
Journal Article
Chalmers, J. R., Axon, E., Harvey, J., Santer, M., Ridd, M. J., Lawton, S., Langan, S., Roberts, A., Ahmed, A., Muller, I., Long, C. M., Panda, S., Chernyshov, P., Carter, B., Williams, H. C., & Thomas, K. S. (2019). Different strategies for using topical corticosteroids in people with eczema. Cochrane Database of Systematic Reviews, 2019(6), Article CD013356. https://doi.org/10.1002/14651858.CD013356

© 2019 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To establish the effectiveness and safety of different ways of using topical corticoster... Read More about Different strategies for using topical corticosteroids in people with eczema.