All Outputs (24)

Development of Resorbable Phosphate-Based Glass Microspheres as MRI Contrast Media Agents (2024)
Journal Article
Molinar-Díaz, J., Arjuna, A., Abrehart, N., McLellan, A., Harris, R., Islam, M. T., Alzaidi, A., Bradley, C. R., Gidman, C., Prior, M. J. W., Titman, J., Blockley, N. P., Harvey, P., Marciani, L., & Ahmed, I. (2024). Development of Resorbable Phosphate-Based Glass Microspheres as MRI Contrast Media Agents. Molecules, 29(18), Article 4296. https://doi.org/10.3390/molecules29184296

In this research, resorbable phosphate-based glass (PBG) compositions were developed using varying modifier oxides including iron (Fe2O3), copper (CuO), and manganese (MnO2), and then processed via a rapid single-stage flame spheroidisation process t... Read More about Development of Resorbable Phosphate-Based Glass Microspheres as MRI Contrast Media Agents.

Clinically Translatable Transcrocetin Delivery Platform for Correction of Tumor Hypoxia and Enhancement of Radiation Therapy Effects (2023)
Journal Article
Diringer, M., Coliat, P., Mathieu, C., Laurent, N., Mura, C., Banerjee, M., …Detappe, A. (2023). Clinically Translatable Transcrocetin Delivery Platform for Correction of Tumor Hypoxia and Enhancement of Radiation Therapy Effects. Small, 19(12), Article 2205961. https://doi.org/10.1002/smll.202205961

Improving the tumor reoxygenation to sensitize the tumor to radiation therapy is a cornerstone in radiation oncology. Here, the pre‐clinical development of a clinically transferable liposomal formulation encapsulating trans sodium crocetinate (NP TSC... Read More about Clinically Translatable Transcrocetin Delivery Platform for Correction of Tumor Hypoxia and Enhancement of Radiation Therapy Effects.

Covalent attachment of active enzymes to upconversion phosphors allows ratiometric detection of substrates (2020)
Journal Article
Burgess, L., Wilson, H., Jones, A. R., Harvey, P., Natrajan, L., & Hay, S. (2020). Covalent attachment of active enzymes to upconversion phosphors allows ratiometric detection of substrates. Chemistry - A European Journal, 26(65), 14817-14822. https://doi.org/10.1002/chem.202001974

Upconverting phosphors (UCPs) convert multiple low energy photons into higher energy emission via the process of photon upconversion and offer an attractive alternative to organic fluorophores for use as luminescent probes. Here, UCPs were capped wit... Read More about Covalent attachment of active enzymes to upconversion phosphors allows ratiometric detection of substrates.

Pro-organic radical contrast agents (“pro-ORCAs”) for real-time MRI of pro-drug activation in biological systems (2020)
Journal Article
Nguyen, H. V.-T., Detappe, A., Harvey, P., Gallagher, N., Mathieu, C., Agius, M. P., …Johnson, J. A. (2020). Pro-organic radical contrast agents (“pro-ORCAs”) for real-time MRI of pro-drug activation in biological systems. Polymer Chemistry, 11(29), 4768-4779. https://doi.org/10.1039/d0py00558d

Nitroxide-based organic-radical contrast agents (ORCAs) are promising as safe next-generation magnetic resonance imaging (MRI) tools. Nevertheless, stimuli-responsive ORCAs that enable MRI monitoring of prodrug activation have not been reported; such... Read More about Pro-organic radical contrast agents (“pro-ORCAs”) for real-time MRI of pro-drug activation in biological systems.

Metal-based imaging agents: progress towards interrogating neurodegenerative disease (2020)
Journal Article
Sedgwick, A. C., Brewster, J. T., Harvey, P., Iovan, D. A., Smith, G., He, X.-P., …James, T. D. (2020). Metal-based imaging agents: progress towards interrogating neurodegenerative disease. Chemical Society Reviews, 2020(10), 2886-2915. https://doi.org/10.1039/c8cs00986d

Central nervous system (CNS) neurodegeneration is defined by a complex series of pathological processes that ultimately lead to death. The precise etiology of these disorders remains unknown. Recent efforts show that a mechanistic understanding of th... Read More about Metal-based imaging agents: progress towards interrogating neurodegenerative disease.

Metallotexaphyrins as MRI-Active Catalytic Antioxidants for Neurodegenerative Disease: A Study on Alzheimer’s Disease (2020)
Journal Article
Brewster II, J. T., Thiabaud, G. D., Harvey, P., Zafar, H., Reuther, J. F., Dell'Acqua, S., …Sessler, J. L. (2020). Metallotexaphyrins as MRI-Active Catalytic Antioxidants for Neurodegenerative Disease: A Study on Alzheimer’s Disease. Chem, 6(3), 703-724. https://doi.org/10.1016/j.chempr.2019.12.016

The complex etiology of neurodegeneration continues to stifle efforts to develop effective therapeutics. New agents elucidating key pathways causing neurodegeneration might serve to increase our understanding and potentially lead to improved treatmen... Read More about Metallotexaphyrins as MRI-Active Catalytic Antioxidants for Neurodegenerative Disease: A Study on Alzheimer’s Disease.

Image-guided neural activity manipulation with a paramagnetic drug (2020)
Journal Article
Bricault, S., Barandov, A., Harvey, P., DeTienne, E., Hai, A., & Jasanoff, A. (2020). Image-guided neural activity manipulation with a paramagnetic drug. Nature Communications, 11(1), Article 136. https://doi.org/10.1038/s41467-019-13933-5

© 2020, The Author(s). Targeted manipulations of neural activity are essential approaches in neuroscience and neurology, but monitoring such procedures in the living brain remains a significant challenge. Here we introduce a paramagnetic analog of th... Read More about Image-guided neural activity manipulation with a paramagnetic drug.

Antibody-targeting of ultra-small nanoparticles enhances imaging sensitivity and enables longitudinal tracking of multiple myeloma (2019)
Journal Article
Detappe, A., Reidy, M., Yu, Y., Mathieu, C., Nguyen, H. V.-T., Coroller, T. P., …Ghoroghchian, P. P. (2019). Antibody-targeting of ultra-small nanoparticles enhances imaging sensitivity and enables longitudinal tracking of multiple myeloma. Nanoscale, 11(43), 20485-20496. https://doi.org/10.1039/c9nr06512a

Monitoring malignant progression and disease recurrence post-therapy are central challenges to improving the outcomes of patients with multiple myeloma (MM). Whereas current detection methods that rely upon bone marrow examination allow for precise m... Read More about Antibody-targeting of ultra-small nanoparticles enhances imaging sensitivity and enables longitudinal tracking of multiple myeloma.

Polyoxazoline-Based Bottlebrush and Brush-Arm Star Polymers via ROMP: Syntheses and Applications as Organic Radical Contrast Agents (2019)
Journal Article
Alvaradejo, G. G., Nguyen, H. V.-T., Harvey, P., Gallagher, N. M., Le, D., Ottaviani, M. F., …Johnson, J. A. (2019). Polyoxazoline-Based Bottlebrush and Brush-Arm Star Polymers via ROMP: Syntheses and Applications as Organic Radical Contrast Agents. ACS Macro Letters, 8(4), 473-478. https://doi.org/10.1021/acsmacrolett.9b00016

Copyright © 2019 American Chemical Society. The synthesis of functional poly(2-alkyl-2-oxazoline) (PAOx) copolymers with complex nanoarchitectures using a graft-through ring-opening metathesis polymerization (ROMP) approach is described. First, well-... Read More about Polyoxazoline-Based Bottlebrush and Brush-Arm Star Polymers via ROMP: Syntheses and Applications as Organic Radical Contrast Agents.

Triply Loaded Nitroxide Brush-Arm Star Polymers Enable Metal-Free Millimetric Tumor Detection by Magnetic Resonance Imaging (2018)
Journal Article
Nguyen, H. V., Detappe, A., Gallagher, N. M., Zhang, H., Harvey, P., Yan, C., …Johnson, J. A. (2018). Triply Loaded Nitroxide Brush-Arm Star Polymers Enable Metal-Free Millimetric Tumor Detection by Magnetic Resonance Imaging. ACS Nano, 12(11), 11343-11354. https://doi.org/10.1021/acsnano.8b06160

© 2018 American Chemical Society. Nitroxides occupy a privileged position among plausible metal-free magnetic resonance imaging (MRI) contrast agents (CAs) due to their inherently low-toxicity profiles; nevertheless, their translational development h... Read More about Triply Loaded Nitroxide Brush-Arm Star Polymers Enable Metal-Free Millimetric Tumor Detection by Magnetic Resonance Imaging.

Sensing Uranyl(VI) Ions by Coordination and Energy Transfer to a Luminescent Europium(III) Complex (2018)
Journal Article
Harvey, P., Nonat, A., Platas-Iglesias, C., Natrajan, L. S., & Charbonnière, L. J. (2018). Sensing Uranyl(VI) Ions by Coordination and Energy Transfer to a Luminescent Europium(III) Complex. Angewandte Chemie, 130(31), 10069-10072. https://doi.org/10.1002/ange.201805316

The release of uranyl(VI) is a hazardous environmental issue, with limited ways to monitor accumulation in situ. Here, we present a method for the detection of uranyl(VI) ions through the utilization of a unique fluorescence energy transfer process t... Read More about Sensing Uranyl(VI) Ions by Coordination and Energy Transfer to a Luminescent Europium(III) Complex.

Probing the brain with molecular fMRI (2018)
Journal Article
Ghosh, S., Harvey, P., Simon, J. C., & Jasanoff, A. (2018). Probing the brain with molecular fMRI. Current Opinion in Neurobiology, 50, 201-210. https://doi.org/10.1016/j.conb.2018.03.009

© 2018 Elsevier Ltd One of the greatest challenges of modern neuroscience is to incorporate our growing knowledge of molecular and cellular-scale physiology into integrated, organismic-scale models of brain function in behavior and cognition. Molecul... Read More about Probing the brain with molecular fMRI.

Expanding the Scope of Biomolecule Monitoring with Ratiometric Signaling from Rare-Earth Upconverting Phosphors (2017)
Journal Article
Oakland, C., Andrews, M. B., Burgess, L., Jones, A., Hay, S., Harvey, P., & Natrajan, L. S. (2017). Expanding the Scope of Biomolecule Monitoring with Ratiometric Signaling from Rare-Earth Upconverting Phosphors. European Journal of Inorganic Chemistry, 2017(44), 5176-5185. https://doi.org/10.1002/ejic.201700717

Upconversion (UC) is a powerful mulitphoton mechanism that converts low‐energy photons into higher energy emission. One of the most investigated UC systems is upconverting phosphors (UCPs). Here, a new, one‐pot synthetic procedure was used to prepare... Read More about Expanding the Scope of Biomolecule Monitoring with Ratiometric Signaling from Rare-Earth Upconverting Phosphors.

Nitroxide-Based Macromolecular Contrast Agents with Unprecedented Transverse Relaxivity and Stability for Magnetic Resonance Imaging of Tumors (2017)
Journal Article
Nguyen, H. V., Chen, Q., Paletta, J. T., Harvey, P., Jiang, Y., Zhang, H., …Johnson, J. A. (2017). Nitroxide-Based Macromolecular Contrast Agents with Unprecedented Transverse Relaxivity and Stability for Magnetic Resonance Imaging of Tumors. ACS Central Science, 3(7), 800-811. https://doi.org/10.1021/acscentsci.7b00253

© 2017 American Chemical Society. Metal-free magnetic resonance imaging (MRI) agents could overcome the established toxicity associated with metal-based agents in some patient populations and enable new modes of functional MRI in vivo. Herein, we rep... Read More about Nitroxide-Based Macromolecular Contrast Agents with Unprecedented Transverse Relaxivity and Stability for Magnetic Resonance Imaging of Tumors.

A new paramagnetically shifted imaging probe for MRI (2016)
Journal Article
Parker, D., Senanayake, P. K., Rogers, N. J., Blamire, A. M., Harvey, P., Finney, K.-L. N., …Maxwell, R. (2017). A new paramagnetically shifted imaging probe for MRI. Magnetic Resonance in Medicine, 77(3), 1307-1317. https://doi.org/10.1002/mrm.26185

© 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. Purpose: To develop and characterize a new paramagnetic contrast agent for molecular imaging... Read More about A new paramagnetically shifted imaging probe for MRI.

Challenging lanthanide relaxation theory: erbium and thulium complexes that show NMR relaxation rates faster than dysprosium and terbium analogues (2015)
Journal Article
Funk, A. M., Harvey, P., Finney, K.-L. N. A., Fox, M. A., Kenwright, A. M., Rogers, N. J., …Parker, D. (2015). Challenging lanthanide relaxation theory: erbium and thulium complexes that show NMR relaxation rates faster than dysprosium and terbium analogues. Physical Chemistry Chemical Physics, 17(25), 16507-16511. https://doi.org/10.1039/c5cp02210j

This journal is © the Owner Societies 2015. Measurements of the proton NMR paramagnetic relaxation rates for several series of isostructural lanthanide(iii) complexes have been performed in aqueous solution over the field range 1.0 to 16.5 Tesla. The... Read More about Challenging lanthanide relaxation theory: erbium and thulium complexes that show NMR relaxation rates faster than dysprosium and terbium analogues.

Critical analysis of the limitations of Bleaney's theory of magnetic anisotropy in paramagnetic lanthanide coordination complexes (2014)
Journal Article
Funk, A. M., Finney, K.-L. N. A., Harvey, P., Kenwright, A. M., Neil, E. R., Rogers, N. J., …Parker, D. (2014). Critical analysis of the limitations of Bleaney's theory of magnetic anisotropy in paramagnetic lanthanide coordination complexes. Chemical Science, 6(3), 1655-1662. https://doi.org/10.1039/c4sc03429e

The origins of the breakdown of Bleaney's theory of magnetic anisotropy are described, based on an analysis of eleven different complexes of the second half of the 4f elements that form isostructural series. An examination of the chemical shift and r... Read More about Critical analysis of the limitations of Bleaney's theory of magnetic anisotropy in paramagnetic lanthanide coordination complexes.

Ratiometric detection of enzyme turnover and flavin reduction using rare-earth upconverting phosphors (2014)
Journal Article
Harvey, P., Oakland, C., Driscoll, M. D., Hay, S., & Natrajan, L. S. (2014). Ratiometric detection of enzyme turnover and flavin reduction using rare-earth upconverting phosphors. Dalton Transactions, 43(14), 5265-5268. https://doi.org/10.1039/c4dt00356j

Gd4O2S:Yb:Tm rare-earth upconversion phosphors have been utilised to monitor the redox behaviour of flavin mononucleotide and report on the turnover of a flavo-protein, (pentaerythritol tetranitrate reductase). The presence of two bands separated by... Read More about Ratiometric detection of enzyme turnover and flavin reduction using rare-earth upconverting phosphors.

Moving the goal posts: enhancing the sensitivity of PARASHIFT proton magnetic resonance imaging and spectroscopy (2013)
Journal Article
Harvey, P., Blamire, A. M., Wilson, J. I., Finney, K.-L. N. A., Funk, A. M., Senanayake, P. K., & Parker, D. (2013). Moving the goal posts: enhancing the sensitivity of PARASHIFT proton magnetic resonance imaging and spectroscopy. Chemical Science, 4(11), 4251-4258. https://doi.org/10.1039/c3sc51526e

Paramagnetic probes for chemical shift imaging are described, in which a reporting tert-butyl resonance is integrated and placed about 6 to 6.5 Å from a lanthanide ion. At this distance, the resonance is shifted to a region of the 1H NMR spectral win... Read More about Moving the goal posts: enhancing the sensitivity of PARASHIFT proton magnetic resonance imaging and spectroscopy.

Characterisation and evaluation of paramagnetic fluorine labelled glycol chitosan conjugates for 19F and 1H magnetic resonance imaging (2013)
Journal Article
Parker, D., De Luca, E., Botta, M., Harvey, P., Chalmers, K. H., Mishra, A., …Wilson, J. I. (2014). Characterisation and evaluation of paramagnetic fluorine labelled glycol chitosan conjugates for 19F and 1H magnetic resonance imaging. Journal of Biological Inorganic Chemistry, 19(2), 215-227. https://doi.org/10.1007/s00775-013-1028-y

Medium molecular weight glycol chitosan conjugates have been prepared, linked by an amide bond to paramagnetic Gd(III), Ho(III) and Dy(III) macrocyclic complexes in which a trifluoromethyl reporter group is located 6.5 Å from the paramagnetic centre.... Read More about Characterisation and evaluation of paramagnetic fluorine labelled glycol chitosan conjugates for 19F and 1H magnetic resonance imaging.