Probing the brain with molecular fMRI

Ghosh, Souparno; Harvey, Peter; Simon, Jacob C; Jasanoff, Alan

Abstract

© 2018 Elsevier Ltd One of the greatest challenges of modern neuroscience is to incorporate our growing knowledge of molecular and cellular-scale physiology into integrated, organismic-scale models of brain function in behavior and cognition. Molecular-level functional magnetic resonance imaging (molecular fMRI) is a new technology that can help bridge these scales by mapping defined microscopic phenomena over large, optically inaccessible regions of the living brain. In this review, we explain how MRI-detectable imaging probes can be used to sensitize noninvasive imaging to mechanistically significant components of neural processing. We discuss how a combination of innovative probe design, advanced imaging methods, and strategies for brain delivery can make molecular fMRI an increasingly successful approach for spatiotemporally resolved studies of diverse neural phenomena, perhaps eventually in people.

Citation

Ghosh, S., Harvey, P., Simon, J. C., & Jasanoff, A. (2018). Probing the brain with molecular fMRI. Current Opinion in Neurobiology, 50, 201-210. https://doi.org/10.1016/j.conb.2018.03.009

• Journal Article Type: Review
• Acceptance Date: Mar 21, 2018
• Online Publication Date: Apr 9, 2018
• Publication Date: Jun 1, 2018
• Deposit Date: Oct 23, 2019
• Journal: Current Opinion in Neurobiology
• Print ISSN: 0959-4388
• Electronic ISSN: 1873-6882
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 50
• Pages: 201-210
• DOI: https://doi.org/10.1016/j.conb.2018.03.009
• Keywords: General Neuroscience
• Public URL: https://nottingham-repository.worktribe.com/output/2829027
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0959438817302489
• Additional Information: This article is maintained by: Elsevier; Article Title: Probing the brain with molecular fMRI; Journal Title: Current Opinion in Neurobiology; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.conb.2018.03.009; Content Type: article; Copyright: © 2018 Elsevier Ltd. All rights reserved.