C=N-containing azaarenes as activating groups in enantioselective catalysis

Best, Daniel; Lam, Hon Wai

Abstract

Nitrogen-containing aromatic heterocycles (azaarenes) are of widespread chemical significance, and chi-ral compounds containing azaarenes feature prominently in pharmaceuticals, agrochemicals, and natural products. This Perspective highlights the use of a relatively underdeveloped strategy to prepare chiral azaarene-containing compounds: exploitation of the C=N bond embedded within certain azaarenes to activate adjacent functionality in catalytic asym-metric reactions. Work in this area has resulted in the development of several different types of catalytic enantioselec-tive processes, including reductions, nucleophilic additions, and reductive couplings. It is hoped that this Perspective will encourage more researchers to work in this promising area.

Citation

Best, D., & Lam, H. W. (2013). C=N-containing azaarenes as activating groups in enantioselective catalysis. Journal of Organic Chemistry, 79(3), https://doi.org/10.1021/jo402414k

• Journal Article Type: Article
• Publication Date: Dec 16, 2013
• Deposit Date: Feb 12, 2016
• Publicly Available Date: Feb 12, 2016
• Journal: Journal of Organic Chemistry
• Print ISSN: 0022-3263
• Electronic ISSN: 1520-6904
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 79
• Issue: 3
• DOI: https://doi.org/10.1021/jo402414k
• Public URL: https://nottingham-repository.worktribe.com/output/720371
• Publisher URL: http://pubs.acs.org/doi/abs/10.1021/jo402414k
• Additional Information: This document is the unedited author's version of a Submitted Work that was subsequently accepted for publication in Journal of Organic Chemistry, copyright © American Chemical Society after peer review. To access the final edited and published work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html