Karolina A. Wartolowska
Using arterial spin labelling to investigate spontaneous and evoked ongoing musculoskeletal pain
Wartolowska, Karolina A.; Bulte, Daniel P.; Chappell, Michael A.; Jenkinson, Mark; Okell, Thomas W.; Webster, Matthew A.; Carr, Andrew J.
Authors
Daniel P. Bulte
Prof MICHAEL CHAPPELL MICHAEL.CHAPPELL@NOTTINGHAM.AC.UK
Professor of Biomedical Imaging
Mark Jenkinson
Thomas W. Okell
Matthew A. Webster
Andrew J. Carr
Abstract
Clinical pain is difficult to study using standard Blood Oxy-genation Level Dependent (BOLD) magnetic resonance imaging because it is often ongoing and, if evoked, it is associated with stimulus-correlated motion. Arterial spin labelling (ASL) offers an attractive alternative. This study used arm repositioning to evoke clinically-relevant musculoskeletal pain in patients with shoulder impingement syndrome. Fifty-five patients were scanned using a multi post-labelling delay pseudo-continuous ASL (pCASL) sequence, first with both arms along the body and then with the affected arm raised into a painful position. Twenty healthy volunteers were scanned as a control group. Arm repositioning resulted in increased perfusion in brain regions involved in sensory processing and movement integration, such as the contralateral primary motor and primary somatosensory cortex, mid- and posterior cingulate cortex, and, bilaterally, in the insular cortex/operculum, putamen, thalamus, midbrain and cerebellum. Perfusion in the thalamus, midbrain and cerebellum was larger in the patient group. Results of a post hoc analysis suggested that the observed perfusion changes were related to pain rather than arm repositioning. This study showed that ASL can be useful in research on clinical ongoing musculoskeletal pain but the technique is not sensitive enough to detect small differences in perfusion.
Citation
Wartolowska, K. A., Bulte, D. P., Chappell, M. A., Jenkinson, M., Okell, T. W., Webster, M. A., & Carr, A. J. (2018). Using arterial spin labelling to investigate spontaneous and evoked ongoing musculoskeletal pain
Other Type | Other |
---|---|
Publication Date | Sep 18, 2018 |
Deposit Date | Sep 28, 2020 |
Publicly Available Date | Nov 25, 2020 |
DOI | https://doi.org/10.1101/163196 |
Public URL | https://nottingham-repository.worktribe.com/output/4930823 |
Additional Information | This is a BioRxiv preprint. |
Files
163196v5.full
(31.5 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by-nc-nd/4.0/
You might also like
Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging
(2014)
Journal Article
Model-based Bayesian inference of brain oxygenation using quantitative BOLD
(2019)
Journal Article
Association of Midlife Cardiovascular Risk Profiles with Cerebral Perfusion at Older Ages
(2019)
Journal Article
ICA-based denoising for ASL perfusion imaging
(2019)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search