A two-tool assessment of the quality of life of patients with breast cancer using generic and disease-specific tools in a Nigerian teaching hospital

Isah, Abdulmuminu; Nwachuya, Chukwuemeka Augustine; Amandi, Nancy Chinwe; Onyehalu, Jennifer Chinaecherem; Umeh, Anthony Uche; Chima, Uzochukwu; Aniefuna, Chisom Victoria; Ugwu, Dickson Onyedikachi; Idabor, Charles Chukwuma; Ekwueme, Valerian Iloabuchi; Onwuakpa, Chukwudum Hilary; Ugochukwu, Ezinwanne Jane; Ma'aji, Hadiza Usman; Jackson, Idongesit Linus; Dim, Obinna Felix; Ukoha-Kalu, Blessing Onyinye

Abstract

Assessing the quality of life (QoL) of breast cancer (BC) patients using a triangulation of tools is crucial for understanding their well-being and tailoring specific interventions to improve their overall experience. The study assessed the QoL of BC patients using a combination of generic and disease-specific validated questionnaires. The study utilized a self-administered questionnaire-based cross-sectional design among BC patients attending the Oncology clinic in a Nigerian teaching hospital. The 23-item EORTC-BR23 questionnaire and the 15-item HRQoL 15D questionnaire were provided to consenting eligible respondents for data collection. Descriptive (e.g., frequency, percentages, mean, median, etc.) and inferential (T-test and one-way ANOVA) statistical analyses were conducted on the cleaned data, with significant p values set at less than 0.05. A total of 60 female BC patients participated in the study. Respondents that were aged 41–50 years and 50–60 years were 20 (33.3%) and 19 (31.7%) respectively. Patients who were diagnosed with BC one year ago before the study were 22 (39.3%) with 51 (85%) reporting no positive family history of BC. Patients who had undergone surgery, radiotherapy, hormonal therapy, and chemotherapy were 52 (86.7%), 27 (45.0%), 14 (24.1%), and 54 (90%) respectively. The patients scored 30.00 ± 4.67% and 72.36 ± 2.93% for future perspective and body image, respectively, in the functional scales of the EORTC-BR23 with a maximum possible score of 100%. On the symptom scale, they scored 47.46 ± 2.52% and 63.40 ± 5.03% for side effects of therapy and being upset about hair loss, respectively. The patients’ quality of life utility score in the 15-D tool was 0.79 ± 0.02. With p values less than 0.005, age, time since diagnosis, and cancer stage were influential determinants of patients’ QoL. The QoL of the participants based on the HRQoL-15D was determined to be high. For the EORTC-BR23, respondents reported high quality of life for body image and sexual function but low quality of life for both sexual enjoyment and future perspective in terms of the functional scale. The symptom scale of EORTC-BR23 showed high symptoms for only the domain of upset by hair loss resulting in low QoL. Socio-demographic factor that affects the QoL of BC patients were age, number of years since diagnosis and stage of BC.

Citation

Isah, A., Nwachuya, C. A., Amandi, N. C., Onyehalu, J. C., Umeh, A. U., Chima, U., Aniefuna, C. V., Ugwu, D. O., Idabor, C. C., Ekwueme, V. I., Onwuakpa, C. H., Ugochukwu, E. J., Ma'aji, H. U., Jackson, I. L., Dim, O. F., & Ukoha-Kalu, B. O. (2024). A two-tool assessment of the quality of life of patients with breast cancer using generic and disease-specific tools in a Nigerian teaching hospital. Journal of Oncology Pharmacy Practice, https://doi.org/10.1177/10781552241266574

• Journal Article Type: Article
• Acceptance Date: Jul 21, 2024
• Online Publication Date: Jul 25, 2024
• Publication Date: Jul 25, 2024
• Deposit Date: Jul 25, 2024
• Publicly Available Date: Aug 7, 2024
• Journal: Journal of Oncology Pharmacy Practice
• Print ISSN: 1078-1552
• Electronic ISSN: 1477-092X
• Publisher: SAGE Publications
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1177/10781552241266574
• Keywords: Breast cancer; quality of life; teaching hospital; disease-specific tools; generic tools
• Public URL: https://nottingham-repository.worktribe.com/output/37601179
• Publisher URL: https://journals.sagepub.com/doi/10.1177/10781552241266574