Peptide YY (PYY) And Neuromedin U (NMU): Effects On Ingestive Behavior

Small, Caroline J.; Jethwa, Preeti H.; Bloom, Stephen R.

Abstract

This chapter discusses the effects of Neuromedin U (NMU) and Peptide YY (PYY) on ingestive behavior and their potential as anti-obesity agents. Many peptides are synthesized and released from the gastrointestinal (GI) tract and the central nervous system (CNS). It is now evident that these peptides influence eating behavior. Peptide YY (PYY) is released postprandially from the gastrointestinal L cells and neuromedin U (NMU) has been found in significant concentrations in both the GI tract and the CNS. Recently NMU has been shown to be a potent anorexigenic peptide and alterations of NMU signaling have been shown to predispose to obesity. Following peripheral administration of PYY3-36, the circulating form of PYY, to mouse, rat, or human, there is marked inhibition of food intake. Obese subjects have lower basal fasting PYY levels and have a smaller postprandial rise. However, obesity does not appear to be associated with resistance to PYY. The administration of the naturally occurring gut hormone may offer a long-term therapeutic approach to weight control without deleterious side effects. © 2006 Elsevier Inc. All rights reserved.

Citation

Small, C. J., Jethwa, P. H., & Bloom, S. R. (2006). Peptide YY (PYY) And Neuromedin U (NMU): Effects On Ingestive Behavior. In A. J. Kastin (Ed.), Handbook of Biologically Active Peptides (945-952). Academic Press. https://doi.org/10.1016/B978-012369442-3/50132-X

• Online Publication Date: Oct 16, 2007
• Publication Date: 2006
• Deposit Date: Jun 25, 2021
• Journal: Handbook of Biologically Active Peptides
• Pages: 945-952
• Book Title: Handbook of Biologically Active Peptides
• Chapter Number: 129
• ISBN: 9780123694423
• DOI: https://doi.org/10.1016/B978-012369442-3/50132-X
• Public URL: https://nottingham-repository.worktribe.com/output/3158471
• Publisher URL: https://www.sciencedirect.com/science/article/pii/B978012369442350132X?via%3Dihub