Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis

Dawson, Camilla; Clunie, Gemma; Evison, Felicity; Duncan, Sallyanne; Whitney, Julie; Houchen-Wolloff, Linzy; Bolton, Charlotte E.; Leavy, Olivia C.; Richardson, Matthew; Omer, Elneima; McAuley, Hamish; Shikotra, Aarti; Singapuri, Amisha; Sereno, Marco; Saunders, Ruth M.; Harris, Victoria C.; Greening, Neil J.; Nolan, Claire Marie; Wootton, Dan Gower; Daynes, Enya; Donaldson, Gavin; Sargent, Jack; Scott, Janet; Pimm, John; Bishop, Lettie; McNarry, Melitta; Hart, Nicholas; Evans, Rachael A.; Singh, Sally; Yates, Tom; Chalder, Trudie; Man, William; Harrison, Ewen; Docherty, Annemarie; Lone, Nazir I.; Quint, Jennifer K.; Chalmers, James; Ho, Ling-Pei; Horsley, Alex Robert; Marks, Michael; Poinasamy, Krisnah; Raman, Betty; Wain, Louise V.; Brightling, Chris; Sharma, Neil; Coffey, Margaret; Kulkarni, Amit; Wallace, Sarah; PHOSP-COVID collaborative Group

Abstract

Objective: Identify prevalence of self-reported swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19.

Design: Multicentre prospective observational cohort study using questionnaire data at visit 1 (2–7 months post discharge) and visit 2 (10–14 months post discharge) from hospitalised patients in the UK. Lasso logistic regression analysis was undertaken to identify associations.

Setting: 64 UK acute hospital Trusts.

Participants: Adults aged >18 years, discharged from an admissions unit or ward at a UK hospital with COVID-19.

Main outcome measures: Self-reported swallow, communication, voice and cognitive compromise.

Results: Compromised swallowing post intensive care unit (post-ICU) admission was reported in 20% (188/955); 60% with swallow problems received invasive mechanical ventilation and were more likely to have undergone proning (p=0.039). Voice problems were reported in 34% (319/946) post-ICU admission who were more likely to have received invasive (p<0.001) or non-invasive ventilation (p=0.001) and to have been proned (p<0.001). Communication compromise was reported in 23% (527/2275) univariable analysis identified associations with younger age (p<0.001), female sex (p<0.001), social deprivation (p<0.001) and being a healthcare worker (p=0.010). Cognitive issues were reported by 70% (1598/2275), consistent at both visits, at visit 1 respondents were more likely to have higher baseline comorbidities and at visit 2 were associated with greater social deprivation (p<0.001).

Conclusion: Swallow, communication, voice and cognitive problems were prevalent post hospitalisation for COVID-19, alongside whole system compromise including reduced mobility and overall health scores. Research and testing of rehabilitation interventions are required at pace to explore these issues.

Citation

Dawson, C., Clunie, G., Evison, F., Duncan, S., Whitney, J., Houchen-Wolloff, L., …PHOSP-COVID collaborative Group. (2023). Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis. BMJ Open Respiratory Research, 10(1), Article e001647. https://doi.org/10.1136/bmjresp-2023-001647

• Journal Article Type: Article
• Acceptance Date: Jun 30, 2023
• Online Publication Date: Jul 26, 2023
• Publication Date: 2023-07
• Deposit Date: Jul 29, 2023
• Publicly Available Date: Aug 2, 2023
• Journal: BMJ Open Respiratory Research
• Electronic ISSN: 2052-4439
• Publisher: BMJ Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 1
• Article Number: e001647
• DOI: https://doi.org/10.1136/bmjresp-2023-001647
• Keywords: Pulmonary and Respiratory Medicine
• Public URL: https://nottingham-repository.worktribe.com/output/23487577
• Publisher URL: https://bmjopenrespres.bmj.com/content/10/1/e001647