Jonghee Yoon
A clinically translatable hyperspectral endoscopy (HySE) system for imaging the gastrointestinal tract
Yoon, Jonghee; Joseph, James; Waterhouse, Dale J.; Luthman, A. Siri; Gordon, George S. D.; di Pietro, Massimiliano; Januszewicz, Wladyslaw; Fitzgerald, Rebecca C.; Bohndiek, Sarah E.
Authors
James Joseph
Dale J. Waterhouse
A. Siri Luthman
GEORGE GORDON GEORGE.GORDON@NOTTINGHAM.AC.UK
Associate Professor
Massimiliano di Pietro
Wladyslaw Januszewicz
Rebecca C. Fitzgerald
Sarah E. Bohndiek
Abstract
Hyperspectral imaging (HSI) enables visualisation of morphological and biochemical information, which could improve disease diagnostic accuracy. Unfortunately, the wide range of image distortions that arise during flexible endoscopy in the clinic have made integration of HSI challenging. To address this challenge, we demonstrate a hyperspectral endoscope (HySE) that simultaneously records intrinsically co-registered hyperspectral and standard-of-care white light images, which allows image distortions to be compensated computationally and an accurate hyperspectral data cube to be reconstructed as the endoscope moves in the lumen. Evaluation of HySE performance shows excellent spatial, spectral and temporal resolution and high colour fidelity. Application of HySE enables: quantification of blood oxygenation levels in tissue mimicking phantoms; differentiation of spectral profiles from normal and pathological ex vivo human tissues; and recording of hyperspectral data under freehand motion within an intact ex vivo pig oesophagus model. HySE therefore shows potential for enabling HSI in clinical endoscopy.
Citation
Yoon, J., Joseph, J., Waterhouse, D. J., Luthman, A. S., Gordon, G. S. D., di Pietro, M., …Bohndiek, S. E. (2019). A clinically translatable hyperspectral endoscopy (HySE) system for imaging the gastrointestinal tract. Nature Communications, 10, Article 1902. https://doi.org/10.1038/s41467-019-09484-4
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 12, 2019 |
Online Publication Date | Apr 23, 2019 |
Publication Date | 2019-12 |
Deposit Date | Jan 22, 2020 |
Publicly Available Date | Jan 22, 2020 |
Journal | Nature Communications |
Electronic ISSN | 2041-1723 |
Publisher | Nature Publishing Group |
Peer Reviewed | Peer Reviewed |
Volume | 10 |
Article Number | 1902 |
DOI | https://doi.org/10.1038/s41467-019-09484-4 |
Public URL | https://nottingham-repository.worktribe.com/output/2217141 |
Publisher URL | https://www.nature.com/articles/s41467-019-09484-4#Abs1 |
Additional Information | Received: 12 January 2018; Accepted: 12 March 2019; First Online: 23 April 2019; : The authors declare no competing interests. |
Files
clinically translatable hyperspectral endoscopy
(2.6 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
You might also like
Reconstruction of Optical Vector-Fields With Applications in Endoscopic Imaging
(2019)
Journal Article
Adaptive, spatially-varying aberration correction for real-time holographic projectors
(2016)
Journal Article
Coherent Imaging Through Multicore Fibres With Applications in Endoscopy
(2019)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search