Liam Jordan
Conditioned place avoidance in the planaria Schmidtea mediterranea: A pre-clinical invertebrate model of anxiety-related disorders
Jordan, Liam; Alcalá, José A.; Urcelay, Gonzalo P.; Prados, Jose
Authors
Abstract
The objective of the present study was to develop a model of avoidance learning and its extinction in planarians (Schmidtea mediterranea). Based on previous experiments showing conditioned place preference, we developed a procedure to investigate conditioned place avoidance (CPA) using shock as an unconditioned stimulus (US) and an automated tracking system to record the animals' behaviour. In Experiment 1, we assessed the unconditioned properties of different shock intensities by measuring post shock activity. In two subsequent experiments we investigated CPA using different designs, surfaces as conditioned stimuli (CSs; rough and smooth), and different US intensities (5 V and 10 V). In general, we observed the successful development of CPA. However, CPA was stronger with higher shock intensities, and we found that, in our preparation, a rough surface is best at entering into an association with the shock than a smooth surface. Finally, we also observed extinction of CPA. The evidence of CPA and its extinction in flatworms validates the planaria as a pre-clinical model for the study of avoidance learning, a hallmark of anxiety disorders.
Citation
Jordan, L., Alcalá, J. A., Urcelay, G. P., & Prados, J. (2023). Conditioned place avoidance in the planaria Schmidtea mediterranea: A pre-clinical invertebrate model of anxiety-related disorders. Behavioural Processes, 210, Article 104894. https://doi.org/10.1016/j.beproc.2023.104894
Journal Article Type | Article |
---|---|
Acceptance Date | May 23, 2023 |
Online Publication Date | May 24, 2023 |
Publication Date | 2023-08 |
Deposit Date | Jul 17, 2023 |
Publicly Available Date | Jul 18, 2023 |
Journal | Behavioural Processes |
Print ISSN | 0376-6357 |
Electronic ISSN | 1872-8308 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 210 |
Article Number | 104894 |
DOI | https://doi.org/10.1016/j.beproc.2023.104894 |
Keywords | Behavioral Neuroscience; Animal Science and Zoology; General Medicine |
Public URL | https://nottingham-repository.worktribe.com/output/21903947 |
Publisher URL | https://www.sciencedirect.com/science/article/pii/S0376635723000761?via%3Dihub |
Additional Information | This article is maintained by: Elsevier; Article Title: Conditioned place avoidance in the planaria Schmidtea mediterranea: A pre-clinical invertebrate model of anxiety-related disorders; Journal Title: Behavioural Processes; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.beproc.2023.104894; Content Type: article; Copyright: © 2023 The Author(s). Published by Elsevier B.V. |
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