Intraluminal impact of food: New insights from MRI

Marciani, Luca; Spiller, Robin

Abstract

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Understanding how the gut responds to food has always been limited by the available investigatory techniques. Previous methods involving intubation and aspiration are largely limited to liquid-only meals. The aim of this review is to describe how MRI has allowed analysis of the processing of complex multiphase meals. This has demonstrated the role of physical factors such as viscosity, fat and fibre content in controlling gastric secretion and motility. It has also allowed the description of changes induced in small bowel water content and the role of osmotic effects of poorly absorbed carbohydrates such as fructose, sorbitol and mannitol. Intestinal secretions can be shown to be stimulated by a range of fruit and vegetables and the effect of this on colonic water content can also be measured. This has been used to demonstrate the mode of action of commonly used laxatives including bran and psyllium. The wealth of data which can be obtained together with its non-invasive nature and safety makes the technique ideal for the serial evaluation of the impact of different nutrients and drugs in both health and disease.

Citation

Marciani, L., & Spiller, R. (2019). Intraluminal impact of food: New insights from MRI. Nutrients, 11(5), Article 1147. https://doi.org/10.3390/nu11051147

• Journal Article Type: Review
• Acceptance Date: May 20, 2019
• Online Publication Date: May 23, 2019
• Publication Date: May 1, 2019
• Deposit Date: May 22, 2019
• Publicly Available Date: May 23, 2019
• Journal: Nutrients
• Electronic ISSN: 2072-6643
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Issue: 5
• Article Number: 1147
• DOI: https://doi.org/10.3390/nu11051147
• Keywords: Food Science
• Public URL: https://nottingham-repository.worktribe.com/output/2082053
• Publisher URL: https://www.mdpi.com/2072-6643/11/5/1147
• Contract Date: May 23, 2019