Dorsal hippocampal lesions disrupt Pavlovian delay conditioning and conditioned-response timing

Tam, Shu K.E.; Bonardi, Charlotte

Abstract

The involvement of the rat dorsal hippocampus (dhpc) in Pavlovian conditioning and timing of conditioned responding was examined in an appetitive preparation in which presentation of a relatively long, 40-s auditory conditioned stimulus (CS) was followed immediately by food delivery. Dorsal hippocampal lesions impaired Pavlovian conditioning in this task. They also produced a deficit in interval timing, replicating previous findings with short CSs. The conditioning and timing deficits observed are consistent with the findings from single-unit recording studies in other species, and suggest that the involvement of the dhpc in Pavlovian processes could be more general than is assumed by many of the current theories of hippocampal function.

Citation

Tam, S. K., & Bonardi, C. (2012). Dorsal hippocampal lesions disrupt Pavlovian delay conditioning and conditioned-response timing. Behavioural Brain Research, 230(1), 259-267. https://doi.org/10.1016/j.bbr.2012.02.016

• Journal Article Type: Article
• Acceptance Date: Feb 8, 2012
• Online Publication Date: Feb 17, 2012
• Publication Date: Apr 21, 2012
• Deposit Date: Dec 10, 2018
• Publicly Available Date: Dec 10, 2018
• Journal: Behavioural Brain Research
• Print ISSN: 0166-4328
• Electronic ISSN: 1872-7549
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 230
• Issue: 1
• Pages: 259-267
• DOI: https://doi.org/10.1016/j.bbr.2012.02.016
• Keywords: Behavioral Neuroscience
• Public URL: https://nottingham-repository.worktribe.com/output/1401003
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0166432812001143