Outputs (44)

Hydrogen sulfide and cell signaling (2011)
Journal Article
Li, L., Rose, P., & Moore, P. K. (2011). Hydrogen sulfide and cell signaling. Annual Review of Pharmacology and Toxicology, 51, 169-187. https://doi.org/10.1146/annurev-pharmtox-010510-100505

Hydrogen sulfide (H2S) is a gaseous mediator synthesized from cysteine by cystathionine λ lyase (CSE) and other naturally occurring enzymes. Pharmacological experiments usingH2S donors and genetic experiments using CSE knockout mice suggest important... Read More about Hydrogen sulfide and cell signaling.

Hypoxia-inducible factor-1α is involved in the pro-angiogenic effect of hydrogen sulfide under hypoxic stress (2010)
Journal Article
Liu, X. H., Pan, L. L., Zhuo, Y., Gong, Q. H., Rose, P., & Zhu, Y. Z. (2010). Hypoxia-inducible factor-1α is involved in the pro-angiogenic effect of hydrogen sulfide under hypoxic stress. Biological and Pharmaceutical Bulletin, 33(9), 1550-1554. https://doi.org/10.1248/bpb.33.1550

Hydrogen sulfide (H2S) is known to have pro-angiogenic properties in mammals. In this study, we examined H2S played the role in pro-angiogenesis mediated by hypoxia-inducible factor (HIF)-1α under hypoxic conditions. Rat brain capillary endothelial c... Read More about Hypoxia-inducible factor-1α is involved in the pro-angiogenic effect of hydrogen sulfide under hypoxic stress.

Protective effects of cysteine analogues on acute myocardial ischemia: Novel modulators of endogenous H2S production (2010)
Journal Article
Wang, Q., Wang, X. L., Liu, H. R., Rose, P., & Zhu, Y. Z. (2010). Protective effects of cysteine analogues on acute myocardial ischemia: Novel modulators of endogenous H2S production. Antioxidants and Redox Signaling, 12(10), 1155-1165. https://doi.org/10.1089/ars.2009.2947

The current study was designed to evaluate the pharmacologic effects of three novel cysteine-containing compounds: S-propyl-l-cysteine (SPC), S-allyl-l-cysteine (SAC), and S-propargyl-l-cysteine (SPRC) on H2S production and antioxidant defenses in an... Read More about Protective effects of cysteine analogues on acute myocardial ischemia: Novel modulators of endogenous H2S production.

The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages (2010)
Journal Article
Whiteman, M., Li, L., Rose, P., Tan, C. H., Parkinson, D. B., & Moore, P. K. (2010). The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages. Antioxidants and Redox Signaling, 12(10), 1147-1154. https://doi.org/10.1089/ars.2009.2899

The role of hydrogen sulfide (H2S) in inflammation is controversial, with both pro- and antiinflammatory effects documented. Many studies have used simple sulfide salts as the source of H2S, which give a rapid bolus of H2S in aqueous solutions and th... Read More about The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages.

S-propargyl-cysteine protects both adult rat hearts and neonatal cardiomyocytes from ischemia/hypoxia injury: The contribution of the hydrogen sulfide-mediated pathway (2009)
Journal Article
Wang, Q., Liu, H. R., Mu, Q., Rose, P., & Zhu, Y. Z. (2009). S-propargyl-cysteine protects both adult rat hearts and neonatal cardiomyocytes from ischemia/hypoxia injury: The contribution of the hydrogen sulfide-mediated pathway. Journal of Cardiovascular Pharmacology, 54(2), 139-146. https://doi.org/10.1097/FJC.0b013e3181ac8e12

In this study, we determined the cardioprotective effects of S-propargyl-cysteine (SPRC), a structural analog of S-allylcysteine (SAC), using in vivo models of acute myocardial infarction (MI) and in vitro hypoxic cardiomyocytes models. MI was create... Read More about S-propargyl-cysteine protects both adult rat hearts and neonatal cardiomyocytes from ischemia/hypoxia injury: The contribution of the hydrogen sulfide-mediated pathway.

The pro-inflammatory oxidant hypochlorous acid induces Bax-dependent mitochondrial permeabilisation and cell death through AIF-/EndoG-dependent pathways (2006)
Journal Article
Whiteman, M., Chu, S. H., Siau, J. L., Rose, P., Sabapathy, K., Schantz, J. T., Cheung, N. S., Spencer, J. P., & Armstrong, J. S. (2007). The pro-inflammatory oxidant hypochlorous acid induces Bax-dependent mitochondrial permeabilisation and cell death through AIF-/EndoG-dependent pathways. Cellular Signalling, 19(4), 705-714. https://doi.org/10.1016/j.cellsig.2006.08.019

At sites of chronic inflammation, such as in the inflamed rheumatoid joint, activated neutrophils release hydrogen peroxide (H2O2) and the enzyme myeloperoxidase to catalyse the formation of hypochlorous acid (HOCl). 3-chlorotyrosine, a marker of HOC... Read More about The pro-inflammatory oxidant hypochlorous acid induces Bax-dependent mitochondrial permeabilisation and cell death through AIF-/EndoG-dependent pathways.

Protective effects of Asian green vegetables against oxidant induced cytotoxicity (2005)
Journal Article
Rose, P., Ong, C. N., & Whiteman, M. (2005). Protective effects of Asian green vegetables against oxidant induced cytotoxicity. World Journal of Gastroenterology, 11(48), 7607-7614. https://doi.org/10.3748/wjg.v11.i48.7607

Aim: To evaluate the antioxidant and phase II detoxification enzyme inducing ability of green leaf vegetables consumed in Asia.

Methods: Th e antioxidant properties of six commonly consumed Asian vegetables were determined using the ABTS, DPPH, d... Read More about Protective effects of Asian green vegetables against oxidant induced cytotoxicity.

Hydrogen sulfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocyanate induced apoptosis (2005)
Journal Article
Rose, P., Moore, P. K., Ming, S. H., Nam, O. C., Armstrong, J. S., & Whiteman, M. (2005). Hydrogen sulfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocyanate induced apoptosis. World Journal of Gastroenterology, 11(26), 3990-3997. https://doi.org/10.3748/wjg.v11.i26.3990

AIM: Hydrogen sulfide (H2S) is a prominent gaseous constituent of the gastrointestinal (GI) tract with known cytotoxic properties. Endogenous concentrations of H2S are reported to range between 0.2-3.4 mmol/L in the GI tract of mice and humans. Consi... Read More about Hydrogen sulfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocyanate induced apoptosis.

Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells (2005)
Journal Article
Rose, P., Huang, Q., Ong, C. N., & Whiteman, M. (2005). Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells. Toxicology and Applied Pharmacology, 209(2), 105-113. https://doi.org/10.1016/j.taap.2005.04.010

A high dietary intake of cruciferous vegetables has been associated with a reduction in numerous human pathologies particularly cancer. In the current study, we examined the inhibitory effects of broccoli (Brassica oleracea var. italica) and watercre... Read More about Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells.

Hypochlorous acid-mediated mitochondrial dysfunction and apoptosis in human hepatoma HepG2 and human fetal liver cells: Role of mitochondrial permeability transition (2005)
Journal Article
Whiteman, M., Rose, P., Jia, L. S., Nam, S. C., Gek, S. T., Halliwell, B., & Armstrong, J. S. (2005). Hypochlorous acid-mediated mitochondrial dysfunction and apoptosis in human hepatoma HepG2 and human fetal liver cells: Role of mitochondrial permeability transition. Free Radical Biology and Medicine, 38(12), 1571-1584. https://doi.org/10.1016/j.freeradbiomed.2005.02.030

Liver cirrhosis is often preceded by overt signs of hepatitis, including parenchymal cell inflammation and infiltration of polymorphonuclear (PMN) leukocytes. Activated PMNs release both reactive oxygen species and reactive halogen species, including... Read More about Hypochlorous acid-mediated mitochondrial dysfunction and apoptosis in human hepatoma HepG2 and human fetal liver cells: Role of mitochondrial permeability transition.