Outputs (33)

VGF-derived peptide, TLQP-21, regulates food intake and body weight in Siberian hamsters (2007)
Journal Article
Jethwa, P. H., Warner, A., Nilaweera, K. N., Brameld, J. M., Keyte, J. W., Carter, W. G., Bolton, N., Bruggraber, M., Morgan, P. J., Barrett, P., & Ebling, F. J. (2007). VGF-derived peptide, TLQP-21, regulates food intake and body weight in Siberian hamsters. Endocrinology, 148(8), 4044-4055. https://doi.org/10.1210/en.2007-0038

The Siberian hamster survives winter by decreasing food intake and catabolizing abdominal fat reserves, resulting in a sustained, profound loss of body weight. VGF gene expression is photoperiodically regulated in the hypothalamus with significantly... Read More about VGF-derived peptide, TLQP-21, regulates food intake and body weight in Siberian hamsters.

Hypothalamic thyroid hormone catabolism acts as a gatekeeper for the seasonal control of body weight and reproduction (2007)
Journal Article
Barrett, P., Ebling, F. J., Schuhler, S., Wilson, D., Ross, A. W., Warner, A., Jethwa, P., Boelen, A., Visser, T. J., Ozanne, D. M., Archer, Z. A., Mercer, J. G., & Morgan, P. J. (2007). Hypothalamic thyroid hormone catabolism acts as a gatekeeper for the seasonal control of body weight and reproduction. Endocrinology, 148(8), 3608-3617. https://doi.org/10.1210/en.2007-0316

Seasonal adaptations in physiology exhibited by many animals involve an interface between biological timing and specific neuroendocrine systems, but the molecular basis of this interface is unknown. In this study of Siberian hamsters, we show that th... Read More about Hypothalamic thyroid hormone catabolism acts as a gatekeeper for the seasonal control of body weight and reproduction.

Peptide YY (PYY) And Neuromedin U (NMU): Effects On Ingestive Behavior (2006)
Book Chapter
Small, C. J., Jethwa, P. H., & Bloom, S. R. (2006). Peptide YY (PYY) And Neuromedin U (NMU): Effects On Ingestive Behavior. In A. J. Kastin (Ed.), Handbook of Biologically Active Peptides (945-952). Academic Press. https://doi.org/10.1016/B978-012369442-3/50132-X

This chapter discusses the effects of Neuromedin U (NMU) and Peptide YY (PYY) on ingestive behavior and their potential as anti-obesity agents. Many peptides are synthesized and released from the gastrointestinal (GI) tract and the central nervous sy... Read More about Peptide YY (PYY) And Neuromedin U (NMU): Effects On Ingestive Behavior.

Neuromedin U (NMU): Brain Peptide (2006)
Book Chapter
Jethwa, P. H., Small, C. J., & Bloom, S. R. (2006). Neuromedin U (NMU): Brain Peptide. In A. J. Kastin (Ed.), Handbook of Biologically Active Peptides (745-751). Academic Press. https://doi.org/10.1016/B978-012369442-3/50106-9

Neuromedin U (NMU) is one of the most abundant neuropeptides and has been found in significant concentrations in both the gastrointestinal (GI) tract and the central nervous system (CNS). There are two molecular forms of NMU; an icosapentapeptide (NM... Read More about Neuromedin U (NMU): Brain Peptide.

Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats (2006)
Journal Article
Thompson, E. L., Murphy, K. G., Patterson, M., Bewick, G. A., Stamp, G. W., Curtis, A. E., Cooke, J. H., Jethwa, P. H., Todd, J. F., Ghatei, M. A., & Bloom, S. R. (2006). Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats. AJP - Endocrinology and Metabolism, 291(5), https://doi.org/10.1152/ajpendo.00040.2006

The kisspeptins are KiSS-1 gene-derived peptides that signal through the G protein-coupled receptor-54 (GPR54) and have recently been shown to be critical regulators of reproduction. Acute intracerebroventricular or peripheral administration of kissp... Read More about Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats.

Neuromedin U partially mediates leptin-induced hypothalamo-pituitary adrenal (HPA) stimulation and has a physiological role in the regulation of the HPA axis in the rat (2006)
Journal Article
Jethwa, P. H., Smith, K. L., Small, C. J., Abbott, C. R., Darch, S. J., Murphy, K. G., Seth, A., Semjonous, N. M., Patel, S. R., Todd, J. F., Ghatei, M. A., & Bloom, S. R. (2006). Neuromedin U partially mediates leptin-induced hypothalamo-pituitary adrenal (HPA) stimulation and has a physiological role in the regulation of the HPA axis in the rat. Endocrinology, 147(6), 2886-2892. https://doi.org/10.1210/en.2005-0983

Intracerebroventricular (ICV) administration of the hypothalamic neuropeptide neuromedin U (NMU) or the adipostat hormone leptin increases plasma ACTH and corticosterone. The relationship between leptin and NMU in the regulation of the hypothalamo-pi... Read More about Neuromedin U partially mediates leptin-induced hypothalamo-pituitary adrenal (HPA) stimulation and has a physiological role in the regulation of the HPA axis in the rat.

Hypothalamic cocaine- and amphetamine-regulated transcript (CART) and agouti-related protein (AgRP) neurons coexpress the NOP1 receptor and nociceptin alters CART and AgRP release (2005)
Journal Article
Bewick, G. A., Dhillo, W. S., Darch, S. J., Murphy, K. G., Gardiner, J. V., Jethwa, P. H., Wing, M. K., Ghatei, M. A., & Bloom, S. R. (2005). Hypothalamic cocaine- and amphetamine-regulated transcript (CART) and agouti-related protein (AgRP) neurons coexpress the NOP1 receptor and nociceptin alters CART and AgRP release. Endocrinology, 146(8), 3526-3534. https://doi.org/10.1210/en.2004-1659

Nociceptin or orphanin FQ (N/OFQ) and its receptor NOP1 are expressed in hypothalamic nuclei involved in energy homeostasis. N/OFQ administered by intracerebroventricular or arcuate nucleus (ARC) injection increases food intake in satiated rats. The... Read More about Hypothalamic cocaine- and amphetamine-regulated transcript (CART) and agouti-related protein (AgRP) neurons coexpress the NOP1 receptor and nociceptin alters CART and AgRP release.

Neuromedin U has a physiological role in the regulation of food intake and partially mediates the effects of leptin (2005)
Journal Article
Jethwa, P. H., Small, C. J., Smith, K. L., Seth, A., Darch, S. J., Abbott, C. R., Murphy, K. G., Todd, J. F., Ghatei, M. A., & Bloom, S. R. (2005). Neuromedin U has a physiological role in the regulation of food intake and partially mediates the effects of leptin. AJP - Endocrinology and Metabolism, 289(2), E301-E305. https://doi.org/10.1152/ajpendo.00404.2004

Intracerebroventricular (ICV) administration of Neuromedin U (NMU), a hypothalamic neuropeptide, or leptin, an adipostat hormone released from adipose tissue, reduces food intake and increases energy expenditure. Leptin stimulates the release of NMU... Read More about Neuromedin U has a physiological role in the regulation of food intake and partially mediates the effects of leptin.

Galanin-Like Peptide Stimulates the Release of Gonadotropin-Releasing Hormone in Vitro and May Mediate the Effects of Leptin on the Hypothalamo-Pituitary-Gonadal Axis (2004)
Journal Article
Seth, A., Stanley, S., Jethwa, P., Gardiner, J., Ghatei, M., & Bloom, S. (2004). Galanin-Like Peptide Stimulates the Release of Gonadotropin-Releasing Hormone in Vitro and May Mediate the Effects of Leptin on the Hypothalamo-Pituitary-Gonadal Axis. Endocrinology, 145(2), 743-750. https://doi.org/10.1210/en.2003-0873

Leptin regulates the hypothalamo-pituitary-gonadal axis in relation to nutritional status. The mechanism through which leptin mediates its effects on neuroendocrine reproductive circuits remains unclear. Galanin-like peptide (GALP) is a recently iden... Read More about Galanin-Like Peptide Stimulates the Release of Gonadotropin-Releasing Hormone in Vitro and May Mediate the Effects of Leptin on the Hypothalamo-Pituitary-Gonadal Axis.

Paraventricular nucleus administration of calcitonin gene-related peptide inhibits food intake and stimulates the hypothalamo-pituitary-adrenal axis (2003)
Journal Article
Dhillo, W. S., Small, C. J., Jethwa, P. H., Russell, S. H., Gardiner, J. V., Bewick, G. A., Seth, A., Murphy, K. G., Ghatei, M. A., & Bloom, S. R. (2003). Paraventricular nucleus administration of calcitonin gene-related peptide inhibits food intake and stimulates the hypothalamo-pituitary-adrenal axis. Endocrinology, 144(4), 1420-1425. https://doi.org/10.1210/en.2002-220902

Calcitonin gene-related protein (CGRP) inhibits food intake and stimulates the hypothalamo-pituitary-adrenal (HPA) axis after intracerebroventricular injection in rats. However, the hypothalamic site and mechanism of action are unknown. We investigat... Read More about Paraventricular nucleus administration of calcitonin gene-related peptide inhibits food intake and stimulates the hypothalamo-pituitary-adrenal axis.