Outputs (4)

Structure of the human Ccr4-Not nuclease module using X-ray crystallography and electron paramagnetic resonance spectroscopy distance measurements (2021)
Journal Article
Zhang, Q., Pavanello, L., Potapov, A., Bartlam, M., & Winkler, G. S. (2022). Structure of the human Ccr4-Not nuclease module using X-ray crystallography and electron paramagnetic resonance spectroscopy distance measurements. Protein Science, 31(3), 758-764. https://doi.org/10.1002/pro.4262

Regulated degradation of mature, cytoplasmic mRNA is a key step in eukaryotic gene regulation. This process is typically initiated by the recruitment of deadenylase enzymes by cis-acting elements in the 3' untranslated region resulting in the shorten... Read More about Structure of the human Ccr4-Not nuclease module using X-ray crystallography and electron paramagnetic resonance spectroscopy distance measurements.

Application of DNP-enhanced solid-state NMR to studies of amyloid-β peptide interaction with lipid membranes (2021)
Journal Article
Deo, T., Cheng, Q., Paul, S., Qiang, W., & Potapov, A. (2021). Application of DNP-enhanced solid-state NMR to studies of amyloid-β peptide interaction with lipid membranes. Chemistry and Physics of Lipids, 236, Article 105071. https://doi.org/10.1016/j.chemphyslip.2021.105071

The cellular membrane disruption induced by the aggregation of Aβ peptide has been proposed as a plausible cause of neuronal cell death during Alzheimer’s disease. The molecular-level details of the Aβ interaction with cellular membranes were previou... Read More about Application of DNP-enhanced solid-state NMR to studies of amyloid-β peptide interaction with lipid membranes.

Application of spherical harmonics for DEER data analysis in systems with a conformational distribution (2020)
Journal Article
Potapov, A. (2020). Application of spherical harmonics for DEER data analysis in systems with a conformational distribution. Journal of Magnetic Resonance, 316, Article 106769. https://doi.org/10.1016/j.jmr.2020.106769

Double electron–electron resonance (DEER) and other pulse electron paramagnetic resonance (EPR) techniques are valuable tools for determining distances between paramagnetic centres. DEER theory is well developed for a scenario where relative orientat... Read More about Application of spherical harmonics for DEER data analysis in systems with a conformational distribution.

Heteronuclear DNP of 1H and 19F nuclei using BDPA as a polarizing agent (2020)
Journal Article
Gennaro, A., Karabanov, A., Potapov, A., & Kockenberger, W. (2020). Heteronuclear DNP of 1H and 19F nuclei using BDPA as a polarizing agent. Physical Chemistry Chemical Physics, 22(15), 7803-7816. https://doi.org/10.1039/d0cp00892c

This work explores the dynamic nuclear polarization (DNP) of 1H and 19F nuclei in a sample of 25/75 (% v/v) fluorobenzene/toluene containing the radical 1,3-bisphenylene-2-phenylallyl radical (BDPA) as a polarizing agent. Previously, heteronuclear ef... Read More about Heteronuclear DNP of 1H and 19F nuclei using BDPA as a polarizing agent.