Outputs (130)

Temporal transcriptomic changes in long non-coding RNAs and messenger RNAs involved in the host immune and metabolic response during Toxoplasma gondii lytic cycle (2022)
Journal Article
Wang, S. S., Zhou, C. X., Elsheikha, H. M., He, J. J., Zou, F. C., Zheng, W. B., Zhu, X. Q., & Zhao, G. H. (2022). Temporal transcriptomic changes in long non-coding RNAs and messenger RNAs involved in the host immune and metabolic response during Toxoplasma gondii lytic cycle. Parasites and Vectors, 15, Article 22. https://doi.org/10.1186/s13071-021-05140-3

Background: Long non-coding RNAs (lncRNAs) are important regulators of various biological and pathological processes, in particular the inflammatory response by modulating the transcriptional control of inflammatory genes. However, the role of lncRNA... Read More about Temporal transcriptomic changes in long non-coding RNAs and messenger RNAs involved in the host immune and metabolic response during Toxoplasma gondii lytic cycle.

Synergy between Toxoplasma gondii type I Δ GRA17 immunotherapy and PD-L1 checkpoint inhibition triggers the regression of targeted and distal tumors (2021)
Journal Article
Zhu, Y. C., Elsheikha, H. M., Wang, J. H., Fang, S., He, J. J., Zhu, X. Q., & Chen, J. (2021). Synergy between Toxoplasma gondii type I Δ GRA17 immunotherapy and PD-L1 checkpoint inhibition triggers the regression of targeted and distal tumors. Journal for ImmunoTherapy of Cancer, 9(11), Article e002970. https://doi.org/10.1136/jitc-2021-002970

Background: In this study, we hypothesize that the ability of the protozoan Toxoplasma gondii to modulate immune response within the tumor might improve the therapeutic effect of immune checkpoint blockade. We examined the synergetic therapeutic acti... Read More about Synergy between Toxoplasma gondii type I Δ GRA17 immunotherapy and PD-L1 checkpoint inhibition triggers the regression of targeted and distal tumors.

Waterborne protozoan outbreaks: An update on the global, regional, and national prevalence from 2017 to 2020 and sources of contamination (2021)
Journal Article
Ma, J. Y., Li, M. Y., Qi, Z. Z., Fu, M., Sun, T. F., Elsheikha, H. M., & Cong, W. (2022). Waterborne protozoan outbreaks: An update on the global, regional, and national prevalence from 2017 to 2020 and sources of contamination. Science of the Total Environment, 806(Part 2), Article 150562. https://doi.org/10.1016/j.scitotenv.2021.150562

The aim of this review is to identify the worldwide trend of waterborne protozoan outbreaks and how it varies between geographic regions during the period from 2017 to 2020. Data about waterborne protozoan outbreaks were gathered and stratified by co... Read More about Waterborne protozoan outbreaks: An update on the global, regional, and national prevalence from 2017 to 2020 and sources of contamination.

Toxocara canis Infection Alters lncRNA and mRNA Expression Profiles of Dog Bone Marrow (2021)
Journal Article
Zheng, W. B., Zou, Y., Liu, Q., Hu, M. H., Elsheikha, H. M., & Zhu, X. Q. (2021). Toxocara canis Infection Alters lncRNA and mRNA Expression Profiles of Dog Bone Marrow. Frontiers in Cell and Developmental Biology, 9, Article 688128. https://doi.org/10.3389/fcell.2021.688128

Bone marrow is the main hematopoietic organ that produces red blood cells, granulocytes, monocyte/macrophages, megakaryocytes, lymphocytes, and myeloid dendritic cells. Many of these cells play roles in the pathogenesis of Toxocara canis infection, a... Read More about Toxocara canis Infection Alters lncRNA and mRNA Expression Profiles of Dog Bone Marrow.

Biology, epidemiology, clinical features, diagnosis, and treatment of selected fish-borne parasitic zoonoses (2021)
Journal Article
Cong, W., & Elsheikha, H. M. (2021). Biology, epidemiology, clinical features, diagnosis, and treatment of selected fish-borne parasitic zoonoses. Yale Journal of Biology and Medicine, 94(2), 297-309

Fish-borne parasites have been part of the global landscape of food-borne zoonotic diseases for many decades and are often endemic in certain regions of the world. The past 20 years or so have seen the expansion of the range of fish-borne parasitic z... Read More about Biology, epidemiology, clinical features, diagnosis, and treatment of selected fish-borne parasitic zoonoses.

Fasciola gigantica–Derived Excretory-Secretory Products Alter the Expression of mRNAs, miRNAs, lncRNAs, and circRNAs Involved in the Immune Response and Metabolism in Goat Peripheral Blood Mononuclear Cells (2021)
Journal Article
Wang, S. S., Chen, D., He, J. J., Zheng, W. B., Tian, A. L., Zhao, G. H., Elsheikha, H. M., & Zhu, X. Q. (2021). Fasciola gigantica–Derived Excretory-Secretory Products Alter the Expression of mRNAs, miRNAs, lncRNAs, and circRNAs Involved in the Immune Response and Metabolism in Goat Peripheral Blood Mononuclear Cells. Frontiers in Immunology, 12, Article 653755. https://doi.org/10.3389/fimmu.2021.653755

Fasciola gigantica produces excretory-secretory products (ESPs) with immune-modulating effects to promote its own survival. In this study, we performed RNA-seq to gain a comprehensive global understanding of changes in the expression of mRNAs, miRNAs... Read More about Fasciola gigantica–Derived Excretory-Secretory Products Alter the Expression of mRNAs, miRNAs, lncRNAs, and circRNAs Involved in the Immune Response and Metabolism in Goat Peripheral Blood Mononuclear Cells.

Should Veterinary Practitioners Be Concerned about Acanthamoeba Keratitis? (2021)
Journal Article
Cooper, E., Cowmeadow, W., & Elsheikha, H. M. (2021). Should Veterinary Practitioners Be Concerned about Acanthamoeba Keratitis?. Parasitologia, 1(1), 12-19. https://doi.org/10.3390/parasitologia1010002

When presented with an animal exhibiting signs of keratitis (inflammation of the cornea), such as impaired vision, mucoid discharges, redness, swelling, and corneal oedema, most veterinarians would think of bacteria, viruses, or fungi as the potentia... Read More about Should Veterinary Practitioners Be Concerned about Acanthamoeba Keratitis?.

1001 MCQs for Parasitology Trainees: The Essential Revision Guide (2021)
Book
Elsheikha, H. (2021). 1001 MCQs for Parasitology Trainees: The Essential Revision Guide. Para Publishing Limited

With a broad range of 1001 multiple choice questions and answers, this book is the ideal resource for all parasitology trainees who need to revise and prepare for parasitology examinations. The questions are representative of curricula of veterinary... Read More about 1001 MCQs for Parasitology Trainees: The Essential Revision Guide.

Dysregulation of hepatic microRNA expression in C57BL/6 mice affected by excretory-secretory products of Fasciola gigantica (2020)
Journal Article
Shi, W., He, J.-J., Mei, X.-F., Lu, K.-J., Zeng, Z.-X., Zhang, Y.-Y., Sheng, Z.-A., Elsheikha, H. M., Huang, W.-Y., & Zhu, X.-Q. (2020). Dysregulation of hepatic microRNA expression in C57BL/6 mice affected by excretory-secretory products of Fasciola gigantica. PLoS Neglected Tropical Diseases, 14(12), Article e0008951. https://doi.org/10.1371/journal.pntd.0008951

The excretory-secretory products released by the liver fluke Fasciola gigantica (FgESPs) play important roles in regulating the host immune response during the infection. Identification of hepatic miRNAs altered by FgESPs may improve our understandin... Read More about Dysregulation of hepatic microRNA expression in C57BL/6 mice affected by excretory-secretory products of Fasciola gigantica.

ROP18-Mediated Transcriptional Reprogramming of HEK293T Cell Reveals New Roles of ROP18 in the Interplay Between Toxoplasma gondii and the Host Cell (2020)
Journal Article
Li, J.-X., He, J.-J., Elsheikha, H. M., Ma, J., Xu, X.-P., & Zhu, X.-Q. (2020). ROP18-Mediated Transcriptional Reprogramming of HEK293T Cell Reveals New Roles of ROP18 in the Interplay Between Toxoplasma gondii and the Host Cell. Frontiers in Cellular and Infection Microbiology, 10, Article 586946. https://doi.org/10.3389/fcimb.2020.586946

Toxoplasma gondii secretes a number of virulence-related effector proteins, such as the rhoptry protein 18 (ROP18). To further broaden our understanding of the molecular functions of ROP18, we examined the transcriptional response of human embryonic... Read More about ROP18-Mediated Transcriptional Reprogramming of HEK293T Cell Reveals New Roles of ROP18 in the Interplay Between Toxoplasma gondii and the Host Cell.