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Outputs (130)

Identification of two novel host proteins interacting with Toxoplasma gondii 14-3-3 protein by yeast two-hybrid system (2018)
Journal Article
Li, F.-C., Liu, Q., Elsheikha, H. M., Yang, W.-B., Hou, J.-L., & Zhu, X.-Q. (in press). Identification of two novel host proteins interacting with Toxoplasma gondii 14-3-3 protein by yeast two-hybrid system. Parasitology Research, https://doi.org/10.1007/s00436-018-5812-z

Toxoplasma gondii deploys many effector proteins in order to hijack and manipulate host cell signaling pathways, allowing parasite colonization, subversion of immune responses, and disease progression. T. gondii effector protein 14-3-3 (Tg14-3-3) pro... Read More about Identification of two novel host proteins interacting with Toxoplasma gondii 14-3-3 protein by yeast two-hybrid system.

Novel Entamoeba findings in nonhuman primates (2018)
Journal Article
Elsheikha, H. M., Regan, C. S., & Clark, C. G. (2018). Novel Entamoeba findings in nonhuman primates. Trends in Parasitology, 34(4), https://doi.org/10.1016/j.pt.2017.12.008

In addition to well-known human-infecting species, Entamoeba species not found in humans have been identified recently in nonhuman primates (NHPs). Importantly, it has become clear that the organism identified as Entamoeba histolytica in NHPs is usua... Read More about Novel Entamoeba findings in nonhuman primates.

Serum metabolic profiling of oocyst-induced Toxoplasma gondii acute and chronic infections in mice using mass-spectrometry (2018)
Journal Article
Zhou, C.-X., Cong, W., Chen, X.-Q., He, S.-Y., Elsheikha, H. M., & Zhu, X.-Q. (2018). Serum metabolic profiling of oocyst-induced Toxoplasma gondii acute and chronic infections in mice using mass-spectrometry. Frontiers in Microbiology, 8, https://doi.org/10.3389/fmicb.2017.02612

Toxoplasma gondii is an obligate intracellular parasite causing severe diseases in immunocompromised individuals and congenitally infected neonates, such as toxoplasmosis encephalitis and toxoplasmic chorioretinitis. This study aimed to determine whe... Read More about Serum metabolic profiling of oocyst-induced Toxoplasma gondii acute and chronic infections in mice using mass-spectrometry.

Expression profiles of genes involved in TLRs and NLRs signaling pathways of water buffaloes infected with Fasciola gigantica (2017)
Journal Article
Zhang, F.-K., Hou, J.-L., Guo, A.-J., Tian, A.-L., Shi, W., Sheng, Z.-A., Zheng, W.-B., Huang, W.-Y., Elsheikha, H. M., & Zhu, X.-Q. (2018). Expression profiles of genes involved in TLRs and NLRs signaling pathways of water buffaloes infected with Fasciola gigantica. Molecular Immunology, 94, https://doi.org/10.1016/j.molimm.2017.12.007

Infection of ruminants and humans with Fasciola gigantica is attracting increasing attention due to its economic impact and public health significance. However, little is known of innate immune responses during F. gigantica infection. Here, we invest... Read More about Expression profiles of genes involved in TLRs and NLRs signaling pathways of water buffaloes infected with Fasciola gigantica.

Dynamic expression of cytokine and transcription factor genes during experimental Fasciola gigantica infection in buffaloes (2017)
Journal Article
Shi, W., Wei, Z.-Y., Elsheikha, H. M., Zhang, F.-K., Sheng, Z.-A., Lu, K.-J., Wang, D.-Y., Huang, W.-Y., & Zhu, X.-Q. (2017). Dynamic expression of cytokine and transcription factor genes during experimental Fasciola gigantica infection in buffaloes. Parasites and Vectors, 10(1), Article 602. https://doi.org/10.1186/s13071-017-2538-1

Background

Determining the mechanisms involved in the immune-pathogenesis of the tropical liver fluke, Fasciola gigantica, is crucial to the development of any effective therapeutic intervention. Here, we examined the differential gene expression... Read More about Dynamic expression of cytokine and transcription factor genes during experimental Fasciola gigantica infection in buffaloes.

Visualizing the interaction of Acanthamoeba castellanii with human retinal epithelial cells by spontaneous Raman and CARS imaging (2017)
Journal Article
Naemat, A., Sinjab, F., McDonald, A., Downes, A., Elfick, A., Elsheikha, H. M., & Notingher, I. (2018). Visualizing the interaction of Acanthamoeba castellanii with human retinal epithelial cells by spontaneous Raman and CARS imaging. Journal of Raman Spectroscopy, 49(3), 412-423. https://doi.org/10.1002/jrs.5296

Improved understanding of the mechanism of nutrient’s uptake can enable targeted manipulation of nutrient sensing pathways in medically important pathogens to a greater degree than is currently possible. In this context, we present the use of spontan... Read More about Visualizing the interaction of Acanthamoeba castellanii with human retinal epithelial cells by spontaneous Raman and CARS imaging.

Seroprevalence of Toxoplasma gondii infection in arthritis patients in eastern China (2017)
Journal Article
Tian, A., Gu, Y.-L., Zhou, N., Cong, W., Liu, G.-X., Elsheikha, H. M., & Zhu, X.-Q. (in press). Seroprevalence of Toxoplasma gondii infection in arthritis patients in eastern China. Infectious Diseases of Poverty, 6, Article 153. https://doi.org/10.1186/s40249-017-0367-2

Background: There is accumulating evidence for an increased susceptibility to infection in patients with arthritis. We sought to understand the epidemiology of Toxoplasma gondii infection in arthritis patients in eastern China, given the paucity of d... Read More about Seroprevalence of Toxoplasma gondii infection in arthritis patients in eastern China.

Cell imaging by phonon microscopy: sub-optical wavelength ultrasound for non-invasive imaging (2017)
Journal Article
Perez-Cota, F., Smith, R. J., Moradi, E., Leija, A. L., Velickovic, K., Marques, L., Webb, K. F., Symonds, M. E., Sottile, V., Elsheikha, H., & Clark, M. (2017). Cell imaging by phonon microscopy: sub-optical wavelength ultrasound for non-invasive imaging

The mechanical properties of cells play an important role in cell function and behavior. This paper presents recent developments that have enabled the use of laser-generated phonons (ultrasound) with sub-optical wavelengths to look inside living cell... Read More about Cell imaging by phonon microscopy: sub-optical wavelength ultrasound for non-invasive imaging.

Serum levels of cytokines in water buffaloes experimentally infected with Fasciola gigantica (2017)
Journal Article
Zhang, F.-K., Guo, A.-J., Hou, J.-L., Sun, M.-M., Sheng, Z.-A., Zhang, X.-X., Huang, W.-Y., Elsheikha, H. M., & Zhu, X.-Q. (2017). Serum levels of cytokines in water buffaloes experimentally infected with Fasciola gigantica. Veterinary Parasitology, 244, 97-101. https://doi.org/10.1016/j.vetpar.2017.07.028

Fasciola gigantica infection in water buffaloes causes significant economic losses especially 27 in developing countries. Although modulation of the host immune response by cytokine 28 neutralization or vaccination is a promising approach to control... Read More about Serum levels of cytokines in water buffaloes experimentally infected with Fasciola gigantica.