Outputs (130)

A novel cross-priming amplification technique combined with lateral flow strips for rapid and visual detection of zoonotic Toxoplasma gondii (2025)
Journal Article
Liang, Y., He, Y.-H., Yang, S.-F., Xie, S.-C., Lv, Y.-H., Cong, W., Elsheikha, H. M., & Zhu, X.-Q. (2025). A novel cross-priming amplification technique combined with lateral flow strips for rapid and visual detection of zoonotic Toxoplasma gondii. Veterinary Parasitology, 334, Article 110402. https://doi.org/10.1016/j.vetpar.2025.110402

Toxoplasma gondii, an obligate intracellular protozoan, infects almost all warm-blooded animals and humans, with felines serving as its sole definitive hosts. Cats release T. gondii oocysts into the environment through feces, contributing to environm... Read More about A novel cross-priming amplification technique combined with lateral flow strips for rapid and visual detection of zoonotic Toxoplasma gondii.

Glabridin exhibits potent inhibitory effects against Toxoplasma gondii in vitro and in vivo (2024)
Journal Article
Wang, L., Zhai, B., Wang, C., Elsheikha, H. M., Guo, H., Zheng, X.-N., Zhou, C., & Zhu, X.-Q. (2024). Glabridin exhibits potent inhibitory effects against Toxoplasma gondii in vitro and in vivo. Parasites and Vectors, 17(1), Article 522. https://doi.org/10.1186/s13071-024-06610-0

Background: Toxoplasma gondii is an obligate protozoan parasite capable of infecting a wide range of warm-blooded animals and humans. Current treatment options, primarily pyrimethamine and sulfadiazine, have limitations, such as high recurrence rates... Read More about Glabridin exhibits potent inhibitory effects against Toxoplasma gondii in vitro and in vivo.

A novel single-tube LAMP-CRISPR/Cas12b method for rapid and visual detection of zoonotic Toxoplasma gondii in the environment (2024)
Journal Article
Liang, Y., Xie, S.-C., Lv, Y.-H., He, Y.-H., Zheng, X.-N., Cong, W., Elsheikha, H. M., & Zhu, X.-Q. (2024). A novel single-tube LAMP-CRISPR/Cas12b method for rapid and visual detection of zoonotic Toxoplasma gondii in the environment. Infectious Diseases of Poverty, 13(1), Article 94. https://doi.org/10.1186/s40249-024-01266-5

Background: Toxoplasma gondii oocysts, excreted in cat feces, pose a significant health risk to humans through contaminated soil and water. Rapid and accurate detection of T. gondii in environmental samples is essential for public health protection.... Read More about A novel single-tube LAMP-CRISPR/Cas12b method for rapid and visual detection of zoonotic Toxoplasma gondii in the environment.

Comprehensive analysis of the global impact and distribution of tick paralysis, a deadly neurological yet fully reversible condition (2024)
Journal Article
Deng, Y.-P., Fu, Y.-T., Elsheikha, H. M., Cao, M.-L., Zhu, X.-Q., Wang, J.-L., Zhang, X., Xie, S.-C., Yao, C., & Liu, G.-H. (2024). Comprehensive analysis of the global impact and distribution of tick paralysis, a deadly neurological yet fully reversible condition. Clinical Microbiology Reviews, 37(4), Article e00074-24. https://doi.org/10.1128/cmr.00074-24

Tick paralysis is a potentially fatal condition caused by neurotoxins secreted by the salivary glands of certain ticks. Documented cases have been reported worldwide, predominantly in the United States, Canada, and Australia, with additional reports... Read More about Comprehensive analysis of the global impact and distribution of tick paralysis, a deadly neurological yet fully reversible condition.

Metagenomic profiling of cecal microbiota and antibiotic resistome in rodents (2024)
Journal Article
Shang, K.-M., Elsheikha, H. M., Ma, H., Wei, Y.-J., Zhao, J.-X., Qin, Y., Li, J.-M., Zhao, Z.-Y., & Zhang, X.-X. (2024). Metagenomic profiling of cecal microbiota and antibiotic resistome in rodents. Ecotoxicology and Environmental Safety, 286, Article 117186. https://doi.org/10.1016/j.ecoenv.2024.117186

The rodent gut microbiota is a known reservoir of antimicrobial resistance, yet the distribution of antibiotic resistance genes (ARGs) within rodent cecal microbial communities and the specific bacterial species harboring these ARGs remain largely un... Read More about Metagenomic profiling of cecal microbiota and antibiotic resistome in rodents.

Urban estuary serves as a critical nexus for the land-sea transfer of the terrestrial pathogen Toxoplasma gondii (2024)
Journal Article
Zhu, X.-K., Elsheikha, H. M., Yang, T., Li, M.-Y., & Cong, W. (2024). Urban estuary serves as a critical nexus for the land-sea transfer of the terrestrial pathogen Toxoplasma gondii. Science of the Total Environment, 955, Article 176983. https://doi.org/10.1016/j.scitotenv.2024.176983

Terrestrial runoff is a key pathway for the transmission of the terrestrial pathogen Toxoplasma gondii from land to sea, posing a significant threat to marine ecosystems. Understanding the mechanisms by which T. gondii is transported from terrestrial... Read More about Urban estuary serves as a critical nexus for the land-sea transfer of the terrestrial pathogen Toxoplasma gondii.

A Colour Atlas of Companion Animal Parasites: Life Cycles and Morphological Identification (2024)
Book
McGarry, J. W., Elsheikha, H. M., & Taylor, S. (2024). A Colour Atlas of Companion Animal Parasites: Life Cycles and Morphological Identification. CAB International

Functional Characterization of Six Eukaryotic Translation Initiation Factors of Toxoplasma gondii Using the CRISPR-Cas9 System (2024)
Journal Article
Kou, Y.-J., Gao, J., Li, R., Ma, Z.-Y., Elsheikha, H. M., Wu, X.-J., Zheng, X.-N., Wang, M., & Zhu, X.-Q. (2024). Functional Characterization of Six Eukaryotic Translation Initiation Factors of Toxoplasma gondii Using the CRISPR-Cas9 System. International Journal of Molecular Sciences, 25(14), Article 7834. https://doi.org/10.3390/ijms25147834

Eukaryotic translation initiation factors (eIFs) are crucial for initiating protein translation and ensuring the correct assembly of mRNA-ribosomal subunit complexes. In this study, we investigated the effects of deleting six eIFs in the apicomplexan... Read More about Functional Characterization of Six Eukaryotic Translation Initiation Factors of Toxoplasma gondii Using the CRISPR-Cas9 System.

Altered landscape of total RNA, tRNA and sncRNA modifications in the liver and spleen of mice infected by Toxoplasma gondii (2024)
Journal Article
Zhang, X.-X., Sun, Y.-Z., Wang, W., Gao, Y., Wei, X.-Y., Sun, H.-C., Wang, C.-R., Ni, H.-B., Yang, X., Elsheikha, H. M., & Guo, H.-P. (2024). Altered landscape of total RNA, tRNA and sncRNA modifications in the liver and spleen of mice infected by Toxoplasma gondii. PLoS Neglected Tropical Diseases, 18(6), Article e0012281. https://doi.org/10.1371/journal.pntd.0012281

Background

Pathogens can impact host RNA modification machinery to establish a favorable cellular environment for their replication. In the present study, we investigated the effect of Toxoplasma gondii infection on host RNA modification profiles... Read More about Altered landscape of total RNA, tRNA and sncRNA modifications in the liver and spleen of mice infected by Toxoplasma gondii.

Comparative cytotoxicity of Acanthamoeba castellanii-derived conditioned medium on human corneal epithelial and stromal cells (2024)
Journal Article
Alhazmi, A., Sidney, L. E., Hopkinson, A., & Elsheikha, H. M. (2024). Comparative cytotoxicity of Acanthamoeba castellanii-derived conditioned medium on human corneal epithelial and stromal cells. Acta Tropica, 257, Article 107288. https://doi.org/10.1016/j.actatropica.2024.107288

Soluble factors in the secretome of Acanthamoeba castellanii play crucial roles in the pathogenesis of Acanthamoeba keratitis (AK). Investigating the pathological effects of A. castellanii-derived conditioned medium (ACCM) on ocular cells can provide... Read More about Comparative cytotoxicity of Acanthamoeba castellanii-derived conditioned medium on human corneal epithelial and stromal cells.