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Incidence, causes and outcomes of lameness cases in a working military horse population: a field study (2013)
Journal Article
Putnam, J., Holmes, L., Green, M. J., & Freeman, S. (2014). Incidence, causes and outcomes of lameness cases in a working military horse population: a field study. Equine Veterinary Journal, 46(2), https://doi.org/10.1111/evj.12084

Reasons for performing study: Lameness is a common problem in the horse. Despite this, information on the incidence of lameness in horses in the UK is restricted to studies of lameness in performance horses, racehorses or referral hospital population... Read More about Incidence, causes and outcomes of lameness cases in a working military horse population: a field study.

Excess maternal salt intake produces sex-specific hypertension in offspring: putative roles for kidney and gastrointestinal sodium handling (2013)
Journal Article
Gray, C., Al-Dujaili, E. A., Sparrow, A. J., Gardiner, S. M., Craigon, J., Welham, S. J., & Gardner, D. S. (2013). Excess maternal salt intake produces sex-specific hypertension in offspring: putative roles for kidney and gastrointestinal sodium handling. PLoS ONE, 8(8), Article e72682. https://doi.org/10.1371/journal.pone.0072682

Hypertension is common and contributes, via cardiovascular disease, towards a large proportion of adult deaths in the Western World. High salt intake leads to high blood pressure, even when occurring prior to birth – a mechanism purported to reside i... Read More about Excess maternal salt intake produces sex-specific hypertension in offspring: putative roles for kidney and gastrointestinal sodium handling.

Curcumin reduces prostaglandin E2, matrix metalloproteinase-3 and proteoglycan release in the secretome of interleukin 1β-treated articular cartilage (2013)
Journal Article
Clutterbuck, A. L., Allaway, D., Harris, P., & Mobasheri, A. (2013). Curcumin reduces prostaglandin E2, matrix metalloproteinase-3 and proteoglycan release in the secretome of interleukin 1β-treated articular cartilage. F1000Research, 2, Article 147. https://doi.org/10.12688/f1000research.2-147.v2

Objective: Curcumin (diferuloylmethane) is a phytochemical with potent anti-inflammatory and anti-oxidant properties, and has therapeutic potential for the treatment of a range of inflammatory diseases, including osteoarthritis (OA). The aim of this... Read More about Curcumin reduces prostaglandin E2, matrix metalloproteinase-3 and proteoglycan release in the secretome of interleukin 1β-treated articular cartilage.

What can mathematical models bring to the control of equine influenza? (2013)
Journal Article
Daly, J. M., Newton, J., Wood, J., & Park, A. (in press). What can mathematical models bring to the control of equine influenza?. Equine Veterinary Journal, 45(6), https://doi.org/10.1111/evj.12104

Mathematical modelling of infectious disease is increasingly regarded as an important tool in the development of disease prevention and control measures. This article brings together key findings from various modelling studies conducted over the past... Read More about What can mathematical models bring to the control of equine influenza?.

Current progress with serological assays for exotic emerging / re-emerging viruses (2013)
Journal Article
Mather, S., Scott, S., Temperton, N., Wright, E., King, B., & Daly, J. (2013). Current progress with serological assays for exotic emerging / re-emerging viruses. Future Virology, 8(8), https://doi.org/10.2217/fvl.13.60

Recent decades have witnessed an unprecedented rise in the outbreak occurrence of infectious and primarily zoonotic viruses. Contributing factors to this phenomenon include heightened global connectivity via air travel and international trade links,... Read More about Current progress with serological assays for exotic emerging / re-emerging viruses.

Expression and function of K(ATP) channels in normal and osteoarthritic human chondrocytes: possible role in glucose sensing (2013)
Journal Article
Rufino, A. T., Rosa, S. C., Judas, F., Mobasheri, A., Lopes, M. C., & Mendes, A. F. (2013). Expression and function of K(ATP) channels in normal and osteoarthritic human chondrocytes: possible role in glucose sensing. Journal of Cellular Biochemistry, 114(8), https://doi.org/10.1002/jcb.24532

ATP-sensitive potassium [K(ATP)] channels sense intracellular ATP/ADP levels, being essential components of a glucose-sensing apparatus in various cells that couples glucose metabolism, intracellular ATP/ADP levels and membrane potential. These chann... Read More about Expression and function of K(ATP) channels in normal and osteoarthritic human chondrocytes: possible role in glucose sensing.

Proactive dairy cattle disease control in the UK: veterinary surgeons' involvement and associated characteristics (2013)
Journal Article
Higgins, H. M., Huxley, J., Wapenaar, W., & Green, M. J. (2013). Proactive dairy cattle disease control in the UK: veterinary surgeons' involvement and associated characteristics. Veterinary Record, 173(10), Article 246. https://doi.org/10.1136/vr.101692

Characteristics of 94 veterinary surgeons associated with delivering preventive herd-level strategies to control mastitis, lameness and Johne's disease were investigated using two multinomial models. The response variables were ‘Gold Standard Monitor... Read More about Proactive dairy cattle disease control in the UK: veterinary surgeons' involvement and associated characteristics.

Sex differences in metabolic and adipose tissue responses to juvenile-onset obesity in sheep (2013)
Journal Article
Bloor, I. D., Sébert, S. P., Saroha, V., Gardner, D. S., Keisler, D. H., Budge, H., …Mahajan, R. P. (2013). Sex differences in metabolic and adipose tissue responses to juvenile-onset obesity in sheep. Endocrinology, 154(10), https://doi.org/10.1210/en.2013-1207

Sex is a major factor determining adipose tissue distribution and the subsequent adverse effects of obesity-related disease including type 2 diabetes. The role of gender on juvenile obesity and the accompanying metabolic and inflammatory responses is... Read More about Sex differences in metabolic and adipose tissue responses to juvenile-onset obesity in sheep.

Polycomb recruitment attenuates retinoic acid–induced transcription of the bivalent NR2F1 gene (2013)
Journal Article
Laursen, K. B., Mongan, N. P., Zhuang, Y., Ng, M. M., Benoit, Y. D., & Gudas, L. J. (2013). Polycomb recruitment attenuates retinoic acid–induced transcription of the bivalent NR2F1 gene. Nucleic Acids Research, 41(13), 6430–6443. https://doi.org/10.1093/nar/gkt367

Polycomb proteins play key roles in mediating epigenetic modifications that occur during cell differentiation. The Polycomb repressive complex 2 (PRC2) mediates the tri-methylation of histone H3 lysine 27 (H3K27me3). In this study, we identify a dist... Read More about Polycomb recruitment attenuates retinoic acid–induced transcription of the bivalent NR2F1 gene.