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Monozygotic twins with NASH cirrhosis: cumulative effect of multiple single nucleotide polymorphisms? (2016)
Journal Article
Grove, J. I., Austin, M., Tibble, J., Aithal, G. P., & Verma, S. (2016). Monozygotic twins with NASH cirrhosis: cumulative effect of multiple single nucleotide polymorphisms?. Annals of Hepatology, 15(2), 277-282

Multiple genetic and environmental factors interact to determine an individual’s predisposition to non-alcoholic fatty liver disease and its phenotypic characteristics. Association studies have found a number of alleles associated with the developmen... Read More about Monozygotic twins with NASH cirrhosis: cumulative effect of multiple single nucleotide polymorphisms?.

Colonic response to laxative ingestion as assessed by MRI differs in constipated irritable bowel syndrome compared to functional constipation (2016)
Journal Article
Lam, C., Chaddock, G., Marciani, L., Costigan, C., Paul, J., Cox, E., Hoad, C., Menys, A., Pritchard, S. E., Garsed, K., Taylor, S., Atkinson, D., Gowland, P. A., & Spiller, R. C. (2016). Colonic response to laxative ingestion as assessed by MRI differs in constipated irritable bowel syndrome compared to functional constipation. Neurogastroenterology and Motility, 28(6), https://doi.org/10.1111/nmo.12784

Background

Functional constipation (FC) and irritable bowel syndrome with constipation (IBS-C) share many symptoms but underlying mechanisms may be different. We have developed a magnetic resonance imaging (MRI) technique to measure intestinal vol... Read More about Colonic response to laxative ingestion as assessed by MRI differs in constipated irritable bowel syndrome compared to functional constipation.

Cohort study of the impact of direct acting antiviral therapy in patients with chronic hepatitis C and decompensated cirrhosis (2016)
Journal Article
Foster, G. R., Irving, W. L., Cheung, M. C., Walker, A. J., Hudson, B. E., Verma, S., McLauchlan, J., Mutimer, D. J., Brown, A., Gelson, W. T., MacDonald, D. C., & Agarwal, K. (2016). Cohort study of the impact of direct acting antiviral therapy in patients with chronic hepatitis C and decompensated cirrhosis. Journal of Hepatology, 64(6), 1224-1231. https://doi.org/10.1016/j.jhep.2016.01.029

Background and Aims: All oral direct-acting antivirals (DAAs) effectively treat chronic hepatitis C virus (HCV) infection, but the benefits in advanced liver disease are unclear. We compared outcomes in treated and untreated patients with decompensat... Read More about Cohort study of the impact of direct acting antiviral therapy in patients with chronic hepatitis C and decompensated cirrhosis.

Risk of symptomatic venous thromboembolism following emergency appendicectomy in adults (2016)
Journal Article
Humes, D., Walker, A. J., Hunt, B., Sultan, A. A., Ludvigsson, J. F., & West, J. (2016). Risk of symptomatic venous thromboembolism following emergency appendicectomy in adults. British Journal of Surgery, 103(4), 443-450. https://doi.org/10.1002/bjs.10091

BACKGROUND: Appendicectomy is the commonest intra-abdominal emergency surgical procedure, and little is known regarding the magnitude and timing of the risk of venous thromboembolism (VTE) after surgery. This study aimed to determine absolute and rel... Read More about Risk of symptomatic venous thromboembolism following emergency appendicectomy in adults.

Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease: A Randomized Clinical Trial (2015)
Journal Article
Hawkey, C. J., Allez, M., Clark, M. M., Labopin, M., Lindsay, J. O., Ricart, E., Rogler, G., Rovira, M., Satsangi, J., Danese, S., Russell, N., Gribben, J., Johnson, P., Larghero, J., Thieblemont, C., Ardizzone, S., Dierickx, D., Ibatici, A., Littlewood, T., Onida, F., …Farge, D. (2015). Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease: A Randomized Clinical Trial. Journal of the American Medical Association, 314(23), 2524-2534. https://doi.org/10.1001/jama.2015.16700

Importance: Case reports and series suggest hematopoietic stem cell transplantation (HSCT) may benefit some patients with Crohn disease.

Objective: To evaluate the effect of autologous HSCT on refractory Crohn disease.

Design, Setting, and Pa... Read More about Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease: A Randomized Clinical Trial.

Ustekinumab for the treatment of Crohn's disease: can it find its niche? (2015)
Journal Article
Ebby G., S., Subrata, G., Marietta, I., & Moran, G. (2016). Ustekinumab for the treatment of Crohn's disease: can it find its niche?. Therapeutic Advances in Gastroenterology, 9(1), 26-36. https://doi.org/10.1177/1756283X15618130

Crohn’s disease is an immune-mediated disease that results in panenteric chronic inflammation in genetically predisposed individuals exposed to an appropriate environment. The past two decades have witnessed the emergence of an important class of dru... Read More about Ustekinumab for the treatment of Crohn's disease: can it find its niche?.

Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study (2015)
Journal Article
Armstrong, M. J., Gaunt, P., Aithal, G. P., Barton, D., Hull, D., Parker, R., Hazlehurst, J. M., Guo, K., Abouda, G., Aldersley, M. A., Stocken, D., Gough, S. C., Tomlinson, J. W., Brown, R. M., Hübscher, S. G., & Newsome, P. N. (in press). Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study. Lancet, 387(10019), https://doi.org/10.1016/S0140-6736%2815%2900803-X

Background

Glucagon-like peptide-1 (GLP-1) analogues reduce hepatic steatosis, concentrations of liver enzymes, and insulin resistance in murine models of fatty liver disease. These analogues are licensed for type 2 diabetes, but their efficacy in... Read More about Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study.