Outputs (588)

A mechanistic multi-centre, parallel group, randomised placebo controlled trial of Mesalazine for treatment of irritable bowel syndrome with diarrhoea (IBS-D) (2015)
Journal Article
Lam, C., Tan, W., Leighton, M., Hastings, M., Lingaya, M., Falcone, Y., Zhou, X., Xu, L., Whorwell, P., Walls, A., Zaitoun, A. M., Montgomery, A., & Spiller, R. C. (2015). A mechanistic multi-centre, parallel group, randomised placebo controlled trial of Mesalazine for treatment of irritable bowel syndrome with diarrhoea (IBS-D). Gut, 65(1), https://doi.org/10.1136/gutjnl-2015-309122

Introduction: Immune activation has been reported in the mucosa of irritable bowel syndrome patients with diarrhoea (IBS-D) and some small studies have suggested that Mesalazine may reduce symptoms. We performed a double blind, randomised placebo con... Read More about A mechanistic multi-centre, parallel group, randomised placebo controlled trial of Mesalazine for treatment of irritable bowel syndrome with diarrhoea (IBS-D).

Aerated drinks increase gastric volume and reduce appetite as assessed by MRI: a randomized, balanced, crossover trial (2015)
Journal Article
Murray, K., Placidi, E., Schuring, E. A. H., Hoad, C. L., Koppenol, W., Arnaudov, L. N., Blom, W. A. M., Pritchard, S. E., Stoyanov, S. D., Gowland, P. A., Spiller, R. C., Peters, H. P. F., & Marciani, L. (2015). Aerated drinks increase gastric volume and reduce appetite as assessed by MRI: a randomized, balanced, crossover trial. American Journal of Clinical Nutrition, 101(2), 270-278. https://doi.org/10.3945/ajcn.114.096974

The role of chronic norovirus infection in the enteropathy associated with common variable immunodeficiency (2015)
Journal Article
Woodward, J. M., Aravintham, A., Gkrania-Klotsas, E., YK Cordero-Ng, A., Bandoh, B. N., Liu, H., Davies, S., Zhang, H., Stevenson, P., Curran, M. D., & Kumararatne, D. (2015). The role of chronic norovirus infection in the enteropathy associated with common variable immunodeficiency. American Journal of Gastroenterology, 110(2), 320–327. https://doi.org/10.1038/ajg.2014.432

High-density mapping of the MHC identifies a shared role for HLA-DRB1(star)01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis (2015)
Journal Article
HAWKEY, C., Abraham, C., Goyette, P., Achkar, J.-P., Boucher, G., Ahmad, T., Mallon, D., Amininejad, L., Ellinghaus, E., Ananthakrishnan, A. N., Jostins, L., Andersen, V., Huang, H., Anderson, C. A., Ripke, S., Andrews, J. M., Gusareva, E. S., Annese, V., Annese, V., Aumais, G., …Zhao, Z. Z. (2015). High-density mapping of the MHC identifies a shared role for HLA-DRB1(star)01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis. Nature Genetics, 47(2), 172–179. https://doi.org/10.1038/ng.3176

Genome-wide association studies of the related chronic inflammatory bowel diseases (IBD) known as Crohn's disease and ulcerative colitis have shown strong evidence of association to the major histocompatibility complex (MHC). This region encodes a la... Read More about High-density mapping of the MHC identifies a shared role for HLA-DRB1(star)01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.

Improvement over time in outcomes for patients undergoing endoscopic therapy for Barrett's oesophagus-related neoplasia: 6-year experience from the first 500 patients treated in the UK patient registry (2014)
Journal Article
Haidry, R. J., Butt, M. A., Dunn, J. M., Gupta, A., Lipman, G., Smart, H. L., Bhandari, P., Smith, L., Willert, R., Fullarton, G., Di Pietro, M., Gordon, C., Penman, I., Barr, H., Patel, P., Kapoor, N., Hoare, J., Narayanasamy, R., Ang, Y., Veitch, A., …Lovat, L. B. (2015). Improvement over time in outcomes for patients undergoing endoscopic therapy for Barrett's oesophagus-related neoplasia: 6-year experience from the first 500 patients treated in the UK patient registry. Gut, 64(8), 1192-1199. https://doi.org/10.1136/gutjnl-2014-308501

Background Barrett's oesophagus (BE) is a pre-malignant condition leading to oesophageal adenocarcinoma (OAC). Treatment of neoplasia at an early stage is desirable. Combined endoscopic mucosal resection (EMR) followed by radiofrequency ablation (RFA... Read More about Improvement over time in outcomes for patients undergoing endoscopic therapy for Barrett's oesophagus-related neoplasia: 6-year experience from the first 500 patients treated in the UK patient registry.

Preoperative carbohydrate supplementation attenuates post-surgery insulin resistance via reduced inflammatory inhibition of the insulin-mediated restraint on muscle pyruvate dehydrogenase kinase 4 expression (2014)
Journal Article
Fosse Gjessing, P., Constantin-Teodosiu, D., Hagve, M., Lobo, D. N., Revhaug, A., & Irtun, Ø. (2015). Preoperative carbohydrate supplementation attenuates post-surgery insulin resistance via reduced inflammatory inhibition of the insulin-mediated restraint on muscle pyruvate dehydrogenase kinase 4 expression. Clinical Nutrition, 34(6), 1177-1183. https://doi.org/10.1016/j.clnu.2014.12.004

Human leukocyte antigen genetic risk factors of drug-induced liver toxicology (2014)
Journal Article
Grove, J., & Aithal, G. (2014). Human leukocyte antigen genetic risk factors of drug-induced liver toxicology. Expert Opinion on Drug Metabolism and Toxicology, 11(3), 395-409. https://doi.org/10.1517/17425255.2015.992414

Introduction: Drug-induced liver injury (DILI) is a rare adverse drug reaction, which impacts significantly on patients. Human leukocyte antigen (HLA) risk alleles have been found to be associated with DILI supporting an immunological basis to DILI p... Read More about Human leukocyte antigen genetic risk factors of drug-induced liver toxicology.

Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett’s Esophagus (2014)
Journal Article
Palles, C., Chegwidden, L., Li, X., Findlay, J. M., Farnham, G., Giner, F. C., Peppelenbosch, M. P., Kovac, M., Adams, C. L., Prenen, H., Briggs, S., Harrison, R., Sanders, S., MacDonald, D., Haigh, C., Tucker, A., Love, S., Nanji, M., deCaestecker, J., Ferry, D., …Jankowski, J. (2015). Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett’s Esophagus. Gastroenterology, 148(2), 367-378. https://doi.org/10.1053/j.gastro.2014.10.041

Toll-like receptor expression in crypt epithelial cells, putative stem cells and intestinal myofibroblasts isolated from controls and patients with inflammatory bowel disease (2014)
Journal Article
Brown, M., Hughes, K., Moossavi, S., Robins, A., & Mahida, Y. (2014). Toll-like receptor expression in crypt epithelial cells, putative stem cells and intestinal myofibroblasts isolated from controls and patients with inflammatory bowel disease. Clinical and Experimental Immunology, 178(1), 28-39. https://doi.org/10.1111/cei.12381

Magnetic resonance spectroscopy measurements of intragastric fat fraction of oil emulsions in humans (2014)
Journal Article
Hussein, M. O., Hoad, C. L., Stephenson, M. C., Cox, E. F., Placidi, E., Pritchard, S. E., Costigan, C., Ribeiro, H., Ciampi, E., Rayment, P., Nandi, A., Hedges, N., Sanderson, P., Peters, H. P., Kruse, I., Marciani, L., Spiller, R. C., & Gowland, P. A. (2015). Magnetic resonance spectroscopy measurements of intragastric fat fraction of oil emulsions in humans. European Journal of Lipid Science and Technology, 117(1), 31-36. https://doi.org/10.1002/ejlt.201400058