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Outputs (547)

Developing the INCLUDE Ethnicity Framework—a tool to help trialists design trials that better reflect the communities they serve (2021)
Journal Article
Treweek, S., Banister, K., Bower, P., Cotton, S., Devane, D., Gardner, H. R., Isaacs, T., Nestor, G., Oshisanya, A., Parker, A., Rochester, L., Soulsby, I., Williams, H., & Witham, M. D. (2021). Developing the INCLUDE Ethnicity Framework—a tool to help trialists design trials that better reflect the communities they serve. Trials, 22(1), Article 337. https://doi.org/10.1186/s13063-021-05276-8

Background

Ensuring that a trial is designed so that its participants reflect those who might benefit from the results, or be spared harms, is key to the potential benefits of the trial reaching all they should. This paper describes the process, f... Read More about Developing the INCLUDE Ethnicity Framework—a tool to help trialists design trials that better reflect the communities they serve.

Using heterogeneity in disease to understand the relationship between health and personality (2021)
Journal Article
James, R., Walsh, D., & Ferguson, E. (2022). Using heterogeneity in disease to understand the relationship between health and personality. Psychology, Health and Medicine, 27(7), 1582-1595. https://doi.org/10.1080/13548506.2021.1903057

The aim of this study was to compare the relationship between two health outcomes (pain and self-reported health) and personality while accounting for heterogeneity in arthritic disease. Traditionally health psychology and other health research has t... Read More about Using heterogeneity in disease to understand the relationship between health and personality.

Can atopic eczema and psoriasis coexist? A systematic review and meta‐analysis (2021)
Journal Article
Cunliffe, A., Gran, S., Ali, U., Grindlay, D., Lax, S., Williams, H., & Burden-Teh, E. (2021). Can atopic eczema and psoriasis coexist? A systematic review and meta‐analysis. Skin Health and Disease, 1(2), Article e29. https://doi.org/10.1002/ski2.29

Importance: Previous studies report both co-existence and mutual exclusivity of atopic eczema (AE) and psoriasis, but these have not been appraised systematically. Knowledge of such disease association throws light on disease mechanisms and may influ... Read More about Can atopic eczema and psoriasis coexist? A systematic review and meta‐analysis.

Interventions for basal cell carcinoma: abridged Cochrane systematic review and grade assessments (2021)
Journal Article
Thomson, J., Hogan, S., Leonardi‐Bee, J., Williams, H., & Bath‐Hextall, F. (2021). Interventions for basal cell carcinoma: abridged Cochrane systematic review and grade assessments. British Journal of Dermatology, 185(3), 499-511. https://doi.org/10.1111/bjd.19809

Background
Basal cell carcinoma (BCC) is the commonest cancer affecting white‐skinned individuals, and worldwide incidence is increasing. Although rarely fatal, BCC is associated with significant morbidity and costs.

Objectives
To assess the eff... Read More about Interventions for basal cell carcinoma: abridged Cochrane systematic review and grade assessments.

Cognitive assessment in multiple sclerosis clinical care: A qualitative evaluation of stakeholder perceptions and preferences (2021)
Journal Article
Elwick, H., Smith, L., Mhizha-Murira, J. R., Topcu, G., Leighton, P., Drummond, A., Evangelou, N., & Das Nair, R. (2022). Cognitive assessment in multiple sclerosis clinical care: A qualitative evaluation of stakeholder perceptions and preferences. Neuropsychological Rehabilitation, 32(7), 1456-1474. https://doi.org/10.1080/09602011.2021.1899942

There is a growing consensus that cognitive assessments should form part of routine clinical care in Multiple Sclerosis (MS). However, what remains unclear is which assessments are preferred by “stakeholders” (including people with MS, family members... Read More about Cognitive assessment in multiple sclerosis clinical care: A qualitative evaluation of stakeholder perceptions and preferences.

Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose (2021)
Journal Article
Reynolds, C. J., Pade, C., Gibbons, J. M., Butler, D. K., Otter, A. D., Menacho, K., Fontana, M., Smit, A., Sackville-West, J. E., Cutino-Moguel, T., Maini, M. K., Chain, B., Noursadeghi, M., Brooks, T., Semper, A., Manisty, C., Treibel, T. A., Moon, J. C., Valdes, A. M., McKnight, Á., …UK COVIDsortium Investigators. (2021). Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose. Science, 372(6549), 1418-1423. https://doi.org/10.1126/science.abh1282

SARS-CoV-2 vaccine rollout has coincided with the spread of variants of concern. We investigated if single dose vaccination, with or without prior infection, confers cross protective immunity to variants. We analyzed T and B cell responses after firs... Read More about Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose.

The patient acceptable symptom state for knee pain - a systematic literature review and meta-analysis (2021)
Presentation / Conference Contribution
Georgopoulos, V., Smith, S., McWilliams, D., Vincent, T., Watt, F., & Walsh, D. The patient acceptable symptom state for knee pain - a systematic literature review and meta-analysis. Presented at Osteoarthritis Society International World Congress, Virtual

Purpose: Knee pain is highly prevalent, most commonly attributed to osteoarthritis in older people, and in younger people often due to internal derangements. Knee pain can be measured using numerical patient-reported outcome measures (PROMs). Several... Read More about The patient acceptable symptom state for knee pain - a systematic literature review and meta-analysis.

Modest effects of dietary supplements during the COVID-19 pandemic: insights from 445 850 users of the COVID-19 Symptom Study app (2021)
Journal Article
Louca, P., Murray, B., Klaser, K., Graham, M. S., Mazidi, M., Leeming, E. R., Thompson, E., Bowyer, R., Drew, D. A., Nguyen, L. H., Merino, J., Gomez, M., Mompeo, O., Costeira, R., Sudre, C. H., Gibson, R., Steves, C. J., Wolf, J., Franks, P. W., Ourselin, S., …Menni, C. (2021). Modest effects of dietary supplements during the COVID-19 pandemic: insights from 445 850 users of the COVID-19 Symptom Study app. BMJ Nutrition, Prevention & Health, 4(1), Article e000250. https://doi.org/10.1136/bmjnph-2021-000250

Objectives Dietary supplements may ameliorate SARS-CoV-2 infection, although scientific evidence to support such a role is lacking. We investigated whether users of the COVID-19 Symptom Study app who regularly took dietary supplements were less likel... Read More about Modest effects of dietary supplements during the COVID-19 pandemic: insights from 445 850 users of the COVID-19 Symptom Study app.

Incidence and risk factors for poor ankle functional recovery, and the development and progression of posttraumatic ankle osteoarthritis after significant ankle ligament injury (SALI): the SALI cohort study protocol (2021)
Journal Article
Bestwick-Stevenson, T., Wyatt, L. A., Palmer, D., Ching, A., Kerslake, R., Coffey, F., Batt, M. E., & Scammell, B. E. (2021). Incidence and risk factors for poor ankle functional recovery, and the development and progression of posttraumatic ankle osteoarthritis after significant ankle ligament injury (SALI): the SALI cohort study protocol. BMC Musculoskeletal Disorders, 22(1), Article 362. https://doi.org/10.1186/s12891-021-04230-8

Background: Ankle sprains are one of the most common musculoskeletal injuries, accounting for up to 5% of all Emergency Department visits in the United Kingdom. Ankle injury may be associated with future ankle osteoarthritis. Up to 70% of ankle osteo... Read More about Incidence and risk factors for poor ankle functional recovery, and the development and progression of posttraumatic ankle osteoarthritis after significant ankle ligament injury (SALI): the SALI cohort study protocol.