Outputs (6)

Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans (2016)
Journal Article
Brook, M. S., Wilkinson, D. J., Mitchell, W. K., Lund, J. N., Phillips, B. E., Szewczyk, N. J., …Atherton, P. J. (2016). Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans. Journal of Physiology, 594(24), 7399-7417. https://doi.org/10.1113/JP272857

Ageing is associated with impaired hypertrophic responses to resistance exercise training (RET). Here we investigated the aetiology of ‘anabolic resistance’ in older humans. Twenty healthy male individuals, 10 younger (Y; 23 ± 1 years) and 10 older (... Read More about Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans.

Supplementing essential amino acids with the nitric oxide precursor, l-arginine, enhances skeletal muscle perfusion without impacting anabolism in older men (2016)
Journal Article
Mitchell, W. K., Phillips, B. E., Wilkinson, D. J., Williams, J. P., Rankin, D., Lund, J. N., …Atherton, P. J. (2017). Supplementing essential amino acids with the nitric oxide precursor, l-arginine, enhances skeletal muscle perfusion without impacting anabolism in older men. Clinical Nutrition, 36(6), https://doi.org/10.1016/j.clnu.2016.09.031

Postprandial limb blood flow and skeletal muscle microvascular perfusion reduce with aging. Here we tested the impact of providing bolus essential amino acids (EAA) in the presence and absence of the nitric oxide precursor, l-Arginine (ARG), upon ske... Read More about Supplementing essential amino acids with the nitric oxide precursor, l-arginine, enhances skeletal muscle perfusion without impacting anabolism in older men.

Oleoylethanolamine and palmitoylethanolamine modulate intestinal permeability in vitro via TRPV1 and PPARα (2016)
Journal Article
Karwad, M. A., Macpherson, T., Wang, B., Theophilidou, E., Sarmad, S., Barrett, D. A., …O'Sullivan, S. (2017). Oleoylethanolamine and palmitoylethanolamine modulate intestinal permeability in vitro via TRPV1 and PPARα. FASEB Journal, 31(2), 469-481. https://doi.org/10.1096/fj.201500132

Cannabinoids modulate intestinal permeability through cannabinoid receptor 1 (CB1). The endocannabinoid-like compounds oleoylethanolamine (OEA) and palmitoylethanolamine (PEA) play an important role in digestive regulation, and we hypothesized they w... Read More about Oleoylethanolamine and palmitoylethanolamine modulate intestinal permeability in vitro via TRPV1 and PPARα.

Gabapentin for the hemodynamic response to intubation: systematic review and meta-analysis (2016)
Journal Article
Doleman, B., Sherwin, M., Lund, J. N., & Williams, J. P. (in press). Gabapentin for the hemodynamic response to intubation: systematic review and meta-analysis. Canadian Journal of Anesthesia / Journal canadien d'anesthésie, 63(9), https://doi.org/10.1007/s12630-016-0668-0

Purpose

Endotracheal intubation is the gold standard for securing the airway before surgery. Nevertheless, this procedure can produce an activation of the sympathetic nervous system and result in a hemodynamic response which, in high-risk patients... Read More about Gabapentin for the hemodynamic response to intubation: systematic review and meta-analysis.

Mortality of emergency abdominal surgery in high-, middle- and low-income countries (2016)
Journal Article
GlobalSurg Collaborative. (2016). Mortality of emergency abdominal surgery in high-, middle- and low-income countries. British Journal of Surgery, 103(8), https://doi.org/10.1002/bjs.10151

Background: Surgical mortality data are collected routinely in high-income countries, yet virtually no low- or middle-income countries have outcome surveillance in place. The aim was prospectively to collect worldwide mortality data following emergen... Read More about Mortality of emergency abdominal surgery in high-, middle- and low-income countries.

A 31-day time to surgery compliant exercise training programme improves aerobic health in the elderly (2016)
Journal Article
Boereboom, C., Phillips, B., Williams, J., & Lund, J. N. (2016). A 31-day time to surgery compliant exercise training programme improves aerobic health in the elderly. Techniques in Coloproctology, 20(6), https://doi.org/10.1007/s10151-016-1455-1

Background: Over 41,000 people were diagnosed with colorectal cancer (CRC) in the UK in 2011. The incidence of CRC increases with age. Many elderly patients undergo surgery for CRC, the only curative treatment. Such patients are exposed to risks, whi... Read More about A 31-day time to surgery compliant exercise training programme improves aerobic health in the elderly.