Outputs (2639)

A rapid genome-proteome approach to identify rate-limiting steps in the butyrate production pathway in probiotic Clostridium butyricum, CBM588 (2025)
Journal Article
Wood, L., Omorotionmwan, B. B., Blanchard, A. M., Dowle, A., Tooth, D., Bailey, T. S., & Griffin, R. (2025). A rapid genome-proteome approach to identify rate-limiting steps in the butyrate production pathway in probiotic Clostridium butyricum, CBM588. Anaerobe, 92, Article 102940. https://doi.org/10.1016/j.anaerobe.2025.102940

Objectives: Clostridium butyricum ferments non-digested dietary fibre in the colon to produce butyric acid. Butyrate is a four-carbon, short-chain fatty acid (SCFA) which has multiple health benefits. Many microbial products of pharmaceutical or indu... Read More about A rapid genome-proteome approach to identify rate-limiting steps in the butyrate production pathway in probiotic Clostridium butyricum, CBM588.

Quantitative analysis of human umbilical vein endothelial cell morphology and tubulogenesis (2025)
Journal Article
Mignone, V., Arruda, M., Kilpatrick, L., Moore, B., Woolard, J., Hill, S., & Goulding, J. (2025). Quantitative analysis of human umbilical vein endothelial cell morphology and tubulogenesis. Journal of Microscopy, https://doi.org/10.1111/jmi.13397

Primary human umbilical vein endothelial cells can grow as both a monolayer in culture and also as a capillary-like network making them an ideal model system in order to study vascular remodelling. Image-based analysis can allow assessment of cell mo... Read More about Quantitative analysis of human umbilical vein endothelial cell morphology and tubulogenesis.

Novel drugs approved by the EMA, the FDA and the MHRA in 2024: A year in review (2025)
Journal Article
Topouzis, S., Papapetropoulos, A., Alexander, S. P., Cortese-Krott, M., Kendall, D. A., Martemyanov, K., Mauro, C., Nagercoil, N., Panettieri, R. A., Patel, H. H., Schulz, R., Stefanska, B., Stephens, G. J., Teixeira, M. M., Vergnolle, N., Wang, X., & Ferdinandy, P. (2025). Novel drugs approved by the EMA, the FDA and the MHRA in 2024: A year in review. British Journal of Pharmacology, 182(7), 1416-1445. https://doi.org/10.1111/bph.17458

In the past year, the European Medicines Agency (EMA), the Food and Drug Administration (FDA) and the Medicines and Healthcare Products Regulatory Agency (MHRA) authorised 53 novel drugs. While the 2024 harvest is not as rich as in 2023, when 70 new... Read More about Novel drugs approved by the EMA, the FDA and the MHRA in 2024: A year in review.

The human HELQ helicase and XRN2 exoribonuclease cooperate in R-loop resolution (2025)
Journal Article
Pan, J. M., Betts, H., Cubbon, A., Bolt, E. L., Soultanas, P., & He, L. (2025). The human HELQ helicase and XRN2 exoribonuclease cooperate in R-loop resolution. Open Biology, 15(2), https://doi.org/10.1098/rsob.240112

The human HELQ helicase is a superfamily 2, 3’-5’ helicase homologous to POLQ and RNA helicases of the Ski2-like subfamily. It is involved in diverse aspects of DNA repair and is an emerging prognosis biomarker and novel drug-target for cancer therap... Read More about The human HELQ helicase and XRN2 exoribonuclease cooperate in R-loop resolution.

Profiling Allosteric Modulators of CB1R with an Allosteric Fluoroprobe (2025)
Journal Article
Carreira, E. M., Kosar, M., Perera, T., Ganzoni, R. L. Z., Sarott, R. C., Borrega-Roman, L., Vitale, R. M., Ligresti, A., Rufer, A. C., Guba, W., Grether, U., Veprintsev, D. B., & Sykes, D. A. (2025). Profiling Allosteric Modulators of CB1R with an Allosteric Fluoroprobe. Angewandte Chemie International Edition, 64(20), Article e202421885. https://doi.org/10.1002/anie.202421885

Allosteric modulation of cannabinoid receptor type 1 (CB1R) offers a promising alternative to conventional therapeutic approaches using orthosteric ligands (OLs). Currently, CB1R allosteric modulators (AMs) are characterized based on their ability to... Read More about Profiling Allosteric Modulators of CB1R with an Allosteric Fluoroprobe.

Acute vascular and cardiac effects of lenvatinib in mice (2025)
Journal Article
Krüger, D. N., Pannucci, P., Wesley, C. D., Neutel, C. H., Martinet, W., De Meyer, G. R., Hill, S. J., Woolard, J., Franssen, C., & Guns, P.-J. (2025). Acute vascular and cardiac effects of lenvatinib in mice. Cardio-Oncology, 11(1), Article 14. https://doi.org/10.1186/s40959-025-00307-8

Background: Tyrosine kinase inhibitors (TKIs) targeting vascular endothelial growth factor(VEGF) receptor signalling are used in cancer therapy to inhibit angiogenesis. Unfortunately, VEGF inhibitors are known to induce severe hypertension in patient... Read More about Acute vascular and cardiac effects of lenvatinib in mice.

Addressing Ethnicity in the Design and Evaluation of an Educational Intervention on Interindividual Variation in Pharmacokinetics (2025)
Journal Article
Koenig, J. A., Olafuyi, O., & Patel, R. (2025). Addressing Ethnicity in the Design and Evaluation of an Educational Intervention on Interindividual Variation in Pharmacokinetics. Pharmacology Research and Perspectives, 13(1), Article e70073. https://doi.org/10.1002/prp2.70073

Interindividual variation in pharmacokinetics can occur due to diet, environmental or lifestyle factors, underlying pathology, and gene variants, typically single nucleotide polymorphisms (SNPs). Genetic mechanisms have received the most attention in... Read More about Addressing Ethnicity in the Design and Evaluation of an Educational Intervention on Interindividual Variation in Pharmacokinetics.

Selection Increases Mitonuclear DNA Discordance but Reconciles Incompatibility in African Cattle (2025)
Journal Article
Shi, X., Ma, C., Chen, N., Xu, M.-M., Kambal, S., Cai, Z.-F., Yang, Q., Adeola, A. C., Liu, L.-S., Wang, J., Lu, W.-F., Li, Y., Msalya, G. M., Lei, C., Mwacharo, J. M., Han, J.-L., Hanotte, O., Zhang, Y.-P., & Peng, M.-S. (2025). Selection Increases Mitonuclear DNA Discordance but Reconciles Incompatibility in African Cattle. Molecular Biology and Evolution, 42(2), Article msaf039. https://doi.org/10.1093/molbev/msaf039

Mitochondrial function relies on the coordinated interactions between genes in the mitochondrial DNA and nuclear genomes. Imperfect interactions following mitonuclear incompatibility may lead to reduced fitness. Mitochondrial DNA introgressions acros... Read More about Selection Increases Mitonuclear DNA Discordance but Reconciles Incompatibility in African Cattle.

Enhancing nanopore adaptive sampling for PromethION using readfish at scale (2025)
Journal Article
Munro, R., Payne, A., Holmes, N., Moore, C., Cahyani, I., & Loose, M. (2025). Enhancing nanopore adaptive sampling for PromethION using readfish at scale. Genome Research, 35(4), 877-885. https://doi.org/10.1101/gr.279329.124

A unique feature of Oxford Nanopore Technologies sequencers, adaptive sampling, allows precise DNA molecule selection from sequencing libraries. Here, we present enhancements to our tool, readfish, enabling all features for the industrial scale Prome... Read More about Enhancing nanopore adaptive sampling for PromethION using readfish at scale.

The development of a food-group, tree classification method and its use in exploring dietary associations with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) and other health-related outcomes in a UK Population (2025)
Journal Article
Alawadi, A. A., Vijay, A., Grove, J. I., Taylor, M. A., & Aithal, G. P. (2025). The development of a food-group, tree classification method and its use in exploring dietary associations with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) and other health-related outcomes in a UK Population. Metabolism Open, 25, Article 100351. https://doi.org/10.1016/j.metop.2025.100351

Background
Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) affects up to one in five people in the UK, with persistent overeating and a sedentary lifestyle being significant risk factors. Exploring dietary patterns at a food level i... Read More about The development of a food-group, tree classification method and its use in exploring dietary associations with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) and other health-related outcomes in a UK Population.