Outputs (2631)

Nitric oxide-mediated neuroinflammatory pathways as treatment targets in neurodegeneration (2025)
Book Chapter
Cale, J., Farr, T. D., Serres, S., & Steinert, J. R. (2025). Nitric oxide-mediated neuroinflammatory pathways as treatment targets in neurodegeneration. In Therapeutic Applications of Nitric Oxide in Cancer and Inflammatory Disorders (79-96). Elsevier. https://doi.org/10.1016/b978-0-443-22354-9.00005-x

Vascular insufficiency associated with a dysfunctional neurovascular unit (NVU) develops over years without obvious clinical symptoms and can be exacerbated by environmental stress or lifestyle choices. Astrocytic responses to endothelial malfunction... Read More about Nitric oxide-mediated neuroinflammatory pathways as treatment targets in neurodegeneration.

The Characterization of a Gonococcal HicAB Toxin–Antitoxin System Capable of Causing Bacteriostatic Growth Arrest (2025)
Journal Article
Bagabas, S. S., Trujillo-Mendoza, J., Stocks, M. J., Turner, D. P. J., & Oldfield, N. J. (in press). The Characterization of a Gonococcal HicAB Toxin–Antitoxin System Capable of Causing Bacteriostatic Growth Arrest. Microorganisms, 13(7), Article 1619. https://doi.org/10.3390/microorganisms13071619

Neisseria gonorrhoeae is the causative agent of the sexually transmitted infection gonorrhea. Preventative vaccines or novel treatments based on a better understanding of the molecular basis of N. gonorrhoeae infection are required as resistance to c... Read More about The Characterization of a Gonococcal HicAB Toxin–Antitoxin System Capable of Causing Bacteriostatic Growth Arrest.

Do turtles get cancer? (2025)
Journal Article
Glaberman, S., Bulls, S. E., Platner, L., Wagner, P., Dreyer, S., Mccain, S., Burgstaller, S., Davis, L. R., Turner, H., Bruins-Van Sonsbeek, L. G. R., Fischer, D., & Chiari, Y. (2025). Do turtles get cancer?. BioScience, 1-7. https://doi.org/10.1093/biosci/biaf100

Turtles are renowned for their extreme longevity and tremendous range in body size. Theoretically, large, long-lived organisms should face higher cancer risks because of increased cell numbers and lifetime cellular turnover, yet cancer appears to be... Read More about Do turtles get cancer?.

CRISPR-Cas induced self-targeting identifies key players in archaeal microhomology mediated end joining (2025)
Journal Article
Lena Sailer, A., Wörtz, J., Smith, V., Stachler, A.-E., Blau, F., Daratha, M., Maier, L.-K., Allers, T., & Marchfelder, A. (2025). CRISPR-Cas induced self-targeting identifies key players in archaeal microhomology mediated end joining. microLife, https://doi.org/10.1093/femsml/uqaf015

DNA repair processes are the foundation for genome integrity and survival, especially in extreme environments where DNA damage occurs more frequently and where archaea are found. Nevertheless, first-hand experimental information on repair pathways in... Read More about CRISPR-Cas induced self-targeting identifies key players in archaeal microhomology mediated end joining.

A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily (2025)
Journal Article
Parr, R. J., Santin, Y. G., Ratkevičiūte, G., Caulton, S. G., Radford, P., Gurvič, D., Jenkins, M., Doyle, M. T., Mead, L., Silale, A., Van Den Berg, B., Knowles, T. J., Sockett, R. E., Stansfeld, P. J., Laloux, G., & Lovering, A. L. (2025). A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily. Nature Communications, 16, Article 6213. https://doi.org/10.1038/s41467-025-61633-0

Outer membrane proteins (OMPs) define the surface biology of Gram-negative bacteria, with roles in adhesion, transport, catalysis and signalling. Specifically, porin beta-barrels are common diffusion channels, predominantly monomeric/trimeric in natu... Read More about A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily.

Mapping the adaptive landscape of Batesian mimicry using 3D-printed stimuli (2025)
Journal Article
Taylor, C. H., Watson, D. J. G., Skelhorn, J., Bell, D., Burdett, S., Codyre, A., Cooley, K., Davies, J. R., Dawson, J. J., D’Cruz, T., Gandhi, S. R., Jackson, H. J., Lowe, R., Ogilvie, E., Pond, A. L., Rees, H., Richardson, J., Sains, J., Short, F., Brignell, C., …Reader, T. (2025). Mapping the adaptive landscape of Batesian mimicry using 3D-printed stimuli. Nature, https://doi.org/10.1038/s41586-025-09216-3

In a classic example of adaptation, harmless Batesian mimics gain protection from predators through resemblance to one or more unpalatable models. Mimics vary greatly in accuracy, and explaining the persistence of inaccurate mimics is an ongoing chal... Read More about Mapping the adaptive landscape of Batesian mimicry using 3D-printed stimuli.

A comparison of the molecular pharmacological properties of current short, long and ultra-long-acting β2-agonists used for asthma and COPD (2025)
Journal Article
Proudman, R. G. W., & Baker, J. G. (in press). A comparison of the molecular pharmacological properties of current short, long and ultra-long-acting β2-agonists used for asthma and COPD. Pharmacology Research and Perspectives, https://doi.org/10.22541/au.174560615.57789698/v1

β-agonists have been used in asthma for 120 years. There are two recent changes: ultra-long-acting agonists for COPD and new asthma guidelines recommending formoterol/ICS inhalers phasing out short-acting salbutamol inhalers. Few studies directly com... Read More about A comparison of the molecular pharmacological properties of current short, long and ultra-long-acting β2-agonists used for asthma and COPD.

Helix-bundle and C-terminal GPCR domains differentially influence GRK-specific functions and β-arrestin-mediated regulation (2025)
Journal Article
Matthees, E. S. F., Haider, R. S., Klement, L., Reichel, M., Blum, N. K., Weitzel, V., Trüpschuch, T., Ziegler, C., Drube, J., Schulz, S., & Hoffmann, C. (2025). Helix-bundle and C-terminal GPCR domains differentially influence GRK-specific functions and β-arrestin-mediated regulation. Nature Communications, 16(1), Article 5430. https://doi.org/10.1038/s41467-025-61281-4

G protein-coupled receptors (GPCRs) orchestrate diverse physiological responses via signaling through G proteins, GPCR kinases (GRKs), and arrestins. While most G protein functions are well-established, the contributions of GRKs and arrestins remain... Read More about Helix-bundle and C-terminal GPCR domains differentially influence GRK-specific functions and β-arrestin-mediated regulation.

Collapse of Lipid Membranes into Distended Lipidic Cubic Phases at High Solvent Levels, Membrane Remodelling, and Self-Repair (2025)
Journal Article
Yeh, V., Goode, A., Khunti, N., Watts, J., Parmenter, C., Fay, M., Johnson, D., Cowieson, N., & Bonev, B. (2025). Collapse of Lipid Membranes into Distended Lipidic Cubic Phases at High Solvent Levels, Membrane Remodelling, and Self-Repair. Journal of the American Chemical Society, https://doi.org/10.1021/jacs.5c07146

Performance plastics, such as poly(methyl methacrylate), underpin the modern economy. Global manufacturing of plastic precursors relies on fossil carbon sources, and the urgently needed shift toward renewable carbon use through biofermentation is hin... Read More about Collapse of Lipid Membranes into Distended Lipidic Cubic Phases at High Solvent Levels, Membrane Remodelling, and Self-Repair.

DNA Replication in Time and Space: The Archaeal Dimension (2025)
Journal Article
Serdyuk, A., & Allers, T. (2025). DNA Replication in Time and Space: The Archaeal Dimension. DNA, 5(2), Article 24. https://doi.org/10.3390/dna5020024

The ability of a nucleic acid molecule to self-replicate is the driving force behind the evolution of cellular life and the transition from RNA to DNA as the genetic material. Thus, the physicochemical properties of genome replication, such as the re... Read More about DNA Replication in Time and Space: The Archaeal Dimension.