Outputs (16)

Membrane-Inserting α-Lipid Polymers: Understanding Lipid Membrane Insertion and Effect on Membrane Fluidity (2025)
Journal Article
Schiazza, L., Yilmaz, G., Gershkovich, P., Yeh, V., Bonev, B., Laughton, C., Stolnik, S., & Mantovani, G. (2025). Membrane-Inserting α-Lipid Polymers: Understanding Lipid Membrane Insertion and Effect on Membrane Fluidity. Chemistry of Materials, https://doi.org/10.1021/acs.chemmater.5c00658

Membrane-inserting materials bearing a lipid residue at one end of their macromolecular chain, α-lipid polymers, are increasingly utilized in biological and pharmaceutical fields. Insertion of these materials into lipid membranes underlines several c... Read More about Membrane-Inserting α-Lipid Polymers: Understanding Lipid Membrane Insertion and Effect on Membrane Fluidity.

Collapse of Lipid Membranes into Distended Lipidic Cubic Phases at High Solvent Levels, Membrane Remodelling, and Self-Repair (2025)
Journal Article
Yeh, V., Goode, A., Khunti, N., Watts, J., Parmenter, C., Fay, M., Johnson, D., Cowieson, N., & Bonev, B. (2025). Collapse of Lipid Membranes into Distended Lipidic Cubic Phases at High Solvent Levels, Membrane Remodelling, and Self-Repair. Journal of the American Chemical Society, 147(28), 24235–24240. https://doi.org/10.1021/jacs.5c07146

Performance plastics, such as poly(methyl methacrylate), underpin the modern economy. Global manufacturing of plastic precursors relies on fossil carbon sources, and the urgently needed shift toward renewable carbon use through biofermentation is hin... Read More about Collapse of Lipid Membranes into Distended Lipidic Cubic Phases at High Solvent Levels, Membrane Remodelling, and Self-Repair.

Quorum-sensing, intra- and inter-species competition in the staphylococci (2023)
Journal Article
Williams, P., Hill, P., Bonev, B., & Chan, W. C. (2023). Quorum-sensing, intra- and inter-species competition in the staphylococci. Microbiology, 169(8), https://doi.org/10.1099/mic.0.001381

In Gram-positive bacteria such as Staphylococcus aureus and the coagulase-negative staphylococci (CoNS), the accessory gene regulator (agr) is a highly conserved but polymorphic quorum-sensing system involved in colonization, virulence and biofilm de... Read More about Quorum-sensing, intra- and inter-species competition in the staphylococci.

Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate (2023)
Journal Article
Bardelang, P., Murray, E. J., Blower, I., Zandomeneghi, S., Goode, A., Hussain, R., Kumari, D., Siligardi, G., Inoue, K., Luckett, J., Doutch, J., Emsley, J., Chan, W. C., Hill, P., Williams, P., & Bonev, B. B. (2023). Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate. Frontiers in Chemistry, 11, Article 1113885. https://doi.org/10.3389/fchem.2023.1113885

Virulence gene expression in the human pathogen, S. aureus is regulated by the agr (accessory gene regulator) quorum sensing (QS) system which is conserved in diverse Gram-positive bacteria. The agr QS signal molecule is an autoinducing peptide (AIP)... Read More about Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate.

Multi-omic based production strain improvement (MOBpsi) for bio-manufacturing of toxic chemicals (2022)
Journal Article
Webb, J. P., Paiva, A. C., Rossoni, L., Alstrom-Moore, A., Springthorpe, V., Vaud, S., Yeh, V., Minde, D. P., Langer, S., Walker, H., Hounslow, A., Nielsen, D. R., Larson, T., Lilley, K., Stephens, G., Thomas, G. H., Bonev, B. B., Kelly, D. J., Conradie, A., & Green, J. (2022). Multi-omic based production strain improvement (MOBpsi) for bio-manufacturing of toxic chemicals. Metabolic Engineering, 72, 133-149. https://doi.org/10.1016/j.ymben.2022.03.004

Robust systematic approaches for the metabolic engineering of cell factories remain elusive. The available models for predicting phenotypical responses and mechanisms are incomplete, particularly within the context of compound toxicity that can be a... Read More about Multi-omic based production strain improvement (MOBpsi) for bio-manufacturing of toxic chemicals.

The Role of Lipid Chains as Determinants of Membrane Stability in the Presence of Styrene (2022)
Journal Article
Yeh, V., Goode, A., Johnson, D., Cowieson, N., & Bonev, B. B. (2022). The Role of Lipid Chains as Determinants of Membrane Stability in the Presence of Styrene. Langmuir, 38(4), 1348-1359. https://doi.org/10.1021/acs.langmuir.1c02332

Biofermentative production of styrene from renewable carbon sources is crucially dependent on strain tolerance and viability at elevated styrene concentrations. Solvent-driven collapse of bacterial plasma membranes limits yields and is technologicall... Read More about The Role of Lipid Chains as Determinants of Membrane Stability in the Presence of Styrene.

Solid state NMR of membrane proteins: Methods and applications (2021)
Journal Article
Yeh, V., & Bonev, B. B. (2021). Solid state NMR of membrane proteins: Methods and applications. Biochemical Society Transactions, 49(4), 1505-1513. https://doi.org/10.1042/BST20200070

Membranes of cells are active barriers, in which membrane proteins perform essential remodelling, transport and recognition functions that are vital to cells. Membrane proteins are key regulatory components of cells and represent essential targets fo... Read More about Solid state NMR of membrane proteins: Methods and applications.

Interactions of polymyxin B with lipopolysaccharide-containing membranes (2021)
Journal Article
Goode, A., Yeh, V., & Bonev, B. B. (2021). Interactions of polymyxin B with lipopolysaccharide-containing membranes. Faraday Discussions, 232, 317-329. https://doi.org/10.1039/d1fd00036e

Bacterial resistance to antibiotics constantly remodels the battlefront between infections and antibiotic therapy. Polymyxin B, a cationic peptide with an anti-Gram-negative spectrum of activity is re-entering use as a last resort measure and as an a... Read More about Interactions of polymyxin B with lipopolysaccharide-containing membranes.

Membrane protein structure determination and characterisation by solution and solid-state nmr (2020)
Journal Article
Yeh, V., Goode, A., & Bonev, B. B. (2020). Membrane protein structure determination and characterisation by solution and solid-state nmr. Biology, 9(11), Article 396. https://doi.org/10.3390/biology9110396

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Biological membranes define the interface of life and its basic unit, the cell. Membrane proteins play key roles in membrane functions, yet their structure and mechanisms remain poorly underst... Read More about Membrane protein structure determination and characterisation by solution and solid-state nmr.

Immunostimulatory efficacy and protective potential of putative TgERK7 protein in mice experimentally infected by Toxoplasma gondii (2020)
Journal Article
Li, Z. Y., Guo, H. T., Calderón-Mantilla, G., He, J. J., Wang, J. L., Bonev, B. B., Zhu, X. Q., & Elsheikha, H. M. (2020). Immunostimulatory efficacy and protective potential of putative TgERK7 protein in mice experimentally infected by Toxoplasma gondii. International Journal of Medical Microbiology, 310(5), https://doi.org/10.1016/j.ijmm.2020.151432

© 2020 The Author(s) The extracellular signal-regulated kinases (ERKs) serve as important determinants of cellular signal transduction pathways, and hence may play important roles during infections. Previous work suggested that putative ERK7 of Toxop... Read More about Immunostimulatory efficacy and protective potential of putative TgERK7 protein in mice experimentally infected by Toxoplasma gondii.