Outputs (170)

Practicality, Validity, and Responsiveness of Using the Proxy Version of the Child Health Utility–9 Dimensions With Children Aged 2 to 5 Years (2024)
Journal Article
Sach, T. H., Williams, H. C., Allen, H., Boyle, R., Kelleher, M., Brown, S., Cork, M., Flohr, C., Jay, N., Lartey, S., Davies, C., Lawton, S., Perkin, M., Ridd, M., Brooks, J., Tarr, S., Wyatt, L., & Thomas, K. (2024). Practicality, Validity, and Responsiveness of Using the Proxy Version of the Child Health Utility–9 Dimensions With Children Aged 2 to 5 Years. Value in Health, https://doi.org/10.1016/j.jval.2024.08.010

Objectives
To assess the practicality, validity and responsiveness of proxy CHU-9D in children aged 2-5 years.

Methods
We used data from BEEP, a UK randomised co... Read More about Practicality, Validity, and Responsiveness of Using the Proxy Version of the Child Health Utility–9 Dimensions With Children Aged 2 to 5 Years.

Exploiting phenotypic heterogeneity to improve production of glutathione by yeast (2024)
Journal Article
Xu, M., Vallières, C., Finnis, C., Winzer, K., & Avery, S. V. (2024). Exploiting phenotypic heterogeneity to improve production of glutathione by yeast. Microbial Cell Factories, 23(1), Article 267. https://doi.org/10.1186/s12934-024-02536-5

Background: Gene expression noise (variation in gene expression among individual cells of a genetically uniform cell population) can result in heterogenous metabolite production by industrial microorganisms, with cultures containing both low- and hig... Read More about Exploiting phenotypic heterogeneity to improve production of glutathione by yeast.

A Hybrid Rehabilitation Program for Adults with Peripheral Artery Disease (HY-PAD): A Pre-Post Intervention Study to Assess Its Feasibility (2024)
Journal Article
Terada, T., Hausen, M., Mir, H., Reed, J. L., & Coutinho, T. D. (2025). A Hybrid Rehabilitation Program for Adults with Peripheral Artery Disease (HY-PAD): A Pre-Post Intervention Study to Assess Its Feasibility. CJC Open, 7(1), 110-119. https://doi.org/10.1016/j.cjco.2024.09.017

Background
Supervised exercise programs improve walking impairment and quality of life (QoL) in patients with peripheral artery disease (PAD). However, such programs are underutilized, due to their limited accessibility. A feasible and effective exe... Read More about A Hybrid Rehabilitation Program for Adults with Peripheral Artery Disease (HY-PAD): A Pre-Post Intervention Study to Assess Its Feasibility.

Visualization of membrane localization and the functional state of CB 2 R pools using matched agonist and inverse agonist probe pairs † (2024)
Journal Article
Wąsińska-Kałwa, M., Omran, A., Mach, L., Scipioni, L., Bouma, J., Li, X., Radetzki, S., Mostinski, Y., Schippers, M., Gazzi, T., van der Horst, C., Brennecke, B., Hanske, A., Kolomeets, Y., Guba, W., Sykes, D., von Kries, J. P., Broichhagen, J., Hua, T., Veprintsev, D., …Nazare, M. (2024). Visualization of membrane localization and the functional state of CB 2 R pools using matched agonist and inverse agonist probe pairs †. Chemical Science, 15(44), 18443-18454. https://doi.org/10.1039/d4sc00402g

The diversity of physiological roles of the endocannabinoid system has turned it into an attractive yet elusive therapeutic target. However, chemical probes with various functionalities could pave the way for a better understanding of the endocannabi... Read More about Visualization of membrane localization and the functional state of CB 2 R pools using matched agonist and inverse agonist probe pairs †.

International review of blood donation screening for anti‐HBc and occult hepatitis B virus infection (2024)
Journal Article
Fu, M. X., Faddy, H. M., Candotti, D., Groves, J., Saa, P., Styles, C., Adesina, O., Perez Carrillo, J., Seltsam, A., Weber‐Schehl, M., O'Brien, S. F., Drews, S. J., Benyin Aidoo, N., Pajares, Á. L., Navarro Perez, L., Deng, X., van de Laar, T., Laperche, S., Lehtisalo, R., Yilmaz, S., …on behalf of the Virology subgroup of the ISBT WP-TTID. (2024). International review of blood donation screening for anti‐HBc and occult hepatitis B virus infection. Transfusion, 64(11), 2144-2156. https://doi.org/10.1111/trf.18018

Background
Hepatitis B core antibody (anti-HBc) screening has been implemented in many blood establishments to help prevent transmission of hepatitis B virus (HBV), including from donors with occult HBV infection (OBI). We review HBV screening algor... Read More about International review of blood donation screening for anti‐HBc and occult hepatitis B virus infection.

PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451 (2024)
Journal Article
Bhansali, D., Tu, N. H., Inoue, K., Teng, S., Li, T., Tran, H. D., Kim, D. H., Dong, J., Peach, C. J., Sokrat, B., Jensen, D. D., Dolan, J. C., Yamano, S., Robinson, V. M., Bunnett, N. W., Albertson, D. G., Leong, K. W., & Schmidt, B. L. (2025). PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451. Biomaterials, 314, Article 122874. https://doi.org/10.1016/j.biomaterials.2024.122874

Oral cancer is notoriously painful. Activation of protease-activated receptor 2 (PAR2, encoded by F2RL1) by proteases in the cancer microenvironment is implicated in oral cancer pain. PAR2 is a G protein-coupled receptor (GPCR) expressed on neurons a... Read More about PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451.

The expanding role of cap-adjacent modifications in animals (2024)
Journal Article
Bellows, E., Fray, R. G., Knight, H. M., & Archer, N. (2024). The expanding role of cap-adjacent modifications in animals. Frontiers in RNA Research, 2, Article 1485307. https://doi.org/10.3389/frnar.2024.1485307

Eukaryotic mRNA cap structures directly influence mRNA stability, translation, and immune recognition. While the significance of the mRNA cap itself has been well-established, recent research has revealed the intricate modifications to the nucleotide... Read More about The expanding role of cap-adjacent modifications in animals.

Fungal Attachment-Resistant Polymers for the Additive Manufacture of Medical Devices (2024)
Journal Article
Yong, L. X., Sefton, J., Vallières, C., Rance, G. A., Hill, J., Cuzzucoli Crucitti, V., Dundas, A. A., Rose, F. R., Alexander, M. R., Wildman, R., He, Y., Avery, S. V., & Irvine, D. J. (2024). Fungal Attachment-Resistant Polymers for the Additive Manufacture of Medical Devices. ACS Applied Materials and Interfaces, 16(40), 54508–54519. https://doi.org/10.1021/acsami.4c04833

This study reports the development of the first copolymer material that (i) is resistant to fungal attachment and hence biofilm formation, (ii) operates via a nonkilling mechanism, i.e., avoids the use of antifungal actives and the emergence of funga... Read More about Fungal Attachment-Resistant Polymers for the Additive Manufacture of Medical Devices.

A Modified Cell-Penetrating Peptide Enhances Insulin and Oxytocin Delivery across an RPMI 2650 Nasal Epithelial Cell Barrier In Vitro (2024)
Journal Article
Wong, S., Brown, A. D., Abrahams, A. B., Nurzak, A. N., Eltaher, H. M., Sykes, D. A., Veprintsev, D. B., Fone, K. C., Dixon, J. E., & King, M. V. (2024). A Modified Cell-Penetrating Peptide Enhances Insulin and Oxytocin Delivery across an RPMI 2650 Nasal Epithelial Cell Barrier In Vitro. Pharmaceutics, 16(10), Article 1267. https://doi.org/10.3390/pharmaceutics16101267

Background/Objectives: Peptide-based treatments represent an expanding area and require innovative approaches to enhance bioavailability. Combination with cell-penetrating peptides (CPPs) is an attractive strategy to improve non-invasive delivery acr... Read More about A Modified Cell-Penetrating Peptide Enhances Insulin and Oxytocin Delivery across an RPMI 2650 Nasal Epithelial Cell Barrier In Vitro.

Local cryptic diversity in salinity adaptation mechanisms in the wild outcrossing Brassica fruticulosa (2024)
Journal Article
Busoms, S., da Silva, A. C., Escolà, G., Abdilzadeh, R., Curran, E., Bollmann-Giolai, A., Bray, S., Wilson, M., Poschenrieder, C., & Yant, L. (2024). Local cryptic diversity in salinity adaptation mechanisms in the wild outcrossing Brassica fruticulosa. Proceedings of the National Academy of Sciences, 121(40), Article e2407821121. https://doi.org/10.1073/pnas.2407821121

It is normally supposed that populations of the same species should evolve shared mechanisms of adaptation to common stressors due to evolutionary constraint. Here, we describe a system of within-species local adaptation to coastal habitats, Brassica... Read More about Local cryptic diversity in salinity adaptation mechanisms in the wild outcrossing Brassica fruticulosa.