Outputs (135)

In vitro models of medulloblastoma: choosing the right tool for the job (2016)
Journal Article
Ivanov, D. P., Coyle, B., Walker, D. A., & Grabowska, A. M. (2016). In vitro models of medulloblastoma: choosing the right tool for the job. Journal of Biotechnology, 236, 10-25. https://doi.org/10.1016/j.jbiotec.2016.07.028

The recently-defined four molecular subgroups of medulloblastoma have required updating of our understanding of in vitro models to include molecular classification and risk stratification features from clinical practice. This review seeks to build a... Read More about In vitro models of medulloblastoma: choosing the right tool for the job.

A qualitative study of professional and carer perceptions of the threats to safe hospital discharge for stroke and hip fracture patients in the English National Health Service (2016)
Journal Article
Waring, J., Bishop, S., & Marshall, F. (in press). A qualitative study of professional and carer perceptions of the threats to safe hospital discharge for stroke and hip fracture patients in the English National Health Service. BMC Health Services Research, 16, https://doi.org/10.1186/s12913-016-1568-2

Background: Hospital discharge is a vulnerable transitional stage in patient care. This qualitative study investigated the views of healthcare professionals and patients about the threats to safe hospital discharge with aim of identifying contributor... Read More about A qualitative study of professional and carer perceptions of the threats to safe hospital discharge for stroke and hip fracture patients in the English National Health Service.

Individual placement and support (IPS) for patients with offending histories: the IPSOH feasibility cluster randomised trial protocol (2016)
Journal Article
Khalifa, N., Talbot, E., Schneider, J. M., Walker, D., Bates, P., Bird, Y., Davies, D., Brookes, C., Hall, J., & Völlm, B. (2016). Individual placement and support (IPS) for patients with offending histories: the IPSOH feasibility cluster randomised trial protocol. BMJ Open, 6(7), Article e012710. https://doi.org/10.1136/bmjopen-2016-012710

Introduction: People with involvement in forensic psychiatric services face many obstacles to employment, arising from their offending, as well as their mental health problems. This study aims to assess the feasibility of conducting a randomised cont... Read More about Individual placement and support (IPS) for patients with offending histories: the IPSOH feasibility cluster randomised trial protocol.

Application of novel analytical ultracentrifuge analysis to solutions of fungal mannans (2016)
Journal Article
Gillis, R. B., Adams, G. G., Besong, D. T., Machová, E., Ebringerová, A., Rowe, A. J., Harding, S. E., & Patel, T. R. (2017). Application of novel analytical ultracentrifuge analysis to solutions of fungal mannans. European Biophysics Journal, 46(3), 235-245. https://doi.org/10.1007/s00249-016-1159-5

Polysaccharides, the most abundant biopolymers, are required for a host of activities in lower organisms, animals, and plants. Their solution characterization is challenging due to their complex shape, heterogeneity, and size. Here, recently develope... Read More about Application of novel analytical ultracentrifuge analysis to solutions of fungal mannans.

Drug-like antagonists of P2Y receptors — from lead identification to drug development (2016)
Journal Article
Conroy, S., Kindon, N., Kellam, B., & Stocks, M. (in press). Drug-like antagonists of P2Y receptors — from lead identification to drug development. Journal of Medicinal Chemistry, https://doi.org/10.1021/acs.jmedchem.5b01972

P2Y receptors are expressed in virtually all cells and tissue types and mediate an astonishing array of biological functions, including platelet aggregation, smooth muscle cell proliferation, and immune regulation. The P2Y receptors belong to the G p... Read More about Drug-like antagonists of P2Y receptors — from lead identification to drug development.

Outcomes after successful direct-acting antiviral therapy for patients with chronic hepatitis C and decompensated cirrhosis (2016)
Journal Article
Cheung, M. C., Walker, A. J., Hudson, B. E., Verma, S., McLauchlan, J., Mutimer, D. J., Brown, A., Gelson, W. T., MacDonald, D. C., Agarwal, K., Foster, G. R., & Irving, W. L. (2016). Outcomes after successful direct-acting antiviral therapy for patients with chronic hepatitis C and decompensated cirrhosis. Journal of Hepatology, 65(4), 741-747. https://doi.org/10.1016/j.jhep.2016.06.019

Direct-acting antivirals have become widely used for patients with chronic hepatitis C virus infection with decompensated cirrhosis. Virological responses are excellent and early improvements in liver function, at least in a proportion of patients, h... Read More about Outcomes after successful direct-acting antiviral therapy for patients with chronic hepatitis C and decompensated cirrhosis.

Associations of limbic-affective brain activity and severity of ongoing chronic arthritis pain are explained by trait anxiety (2016)
Journal Article
Cottam, W. J., Condon, L., Alshuft, H., Reckziegel, D., & Auer, D. P. (in press). Associations of limbic-affective brain activity and severity of ongoing chronic arthritis pain are explained by trait anxiety. NeuroImage: Clinical, 12, https://doi.org/10.1016/j.nicl.2016.06.022

Functional magnetic resonance imaging studies (fMRI) have transformed our understanding of central processing of evoked pain but the typically used block and event-related designs are not best suited to the study of ongoing pain. Here we used arteria... Read More about Associations of limbic-affective brain activity and severity of ongoing chronic arthritis pain are explained by trait anxiety.

Metformin for endometrial hyperplasia (protocol) (2016)
Journal Article
Clement, N., Oliver, T. R., Shiwani, H., Sanner, J. R., Mulvaney, C. A., & Atiomo, W. (2016). Metformin for endometrial hyperplasia (protocol). Cochrane Database of Systematic Reviews, 5, Article CD012214. https://doi.org/10.1002/14651858

To determine the efficacy and safety of metformin in treating women with endometrial hyperplasia

Ten-year outcomes in first episode psychotic major depression patients compared with schizophrenia and bipolar patients (2016)
Journal Article
Heslin, M., Lappin, J., Donoghue, K., Lomas, B., Reininghaus, U., Onyejiaka, A., Croudace, T., Jones, P., Murray, R., Fearon, P., Doody, G., Dazzan, P., Craig, T., & Morgan, C. (2016). Ten-year outcomes in first episode psychotic major depression patients compared with schizophrenia and bipolar patients. Schizophrenia Research, 176(2-3), 417-422. https://doi.org/10.1016/j.schres.2016.04.049

We aimed to investigate long-term outcomes in psychotic major depression patients compared to schizophrenia and bipolar/manic psychosis patients, in an incidence sample, while accounting for diagnostic change. Based on Aetiology and Ethnicity in Schi... Read More about Ten-year outcomes in first episode psychotic major depression patients compared with schizophrenia and bipolar patients.

Improving health-related quality of life in single-sided deafness: a systematic review and meta-analysis (2016)
Journal Article
Kitterick, P. T., Lucas, L., & Smith, S. N. (2016). Improving health-related quality of life in single-sided deafness: a systematic review and meta-analysis. Audiology and Neurotology, 20(Supp 1), https://doi.org/10.1159/000380753

Unilateral severe-to-profound hearing loss, or single-sided deafness (SSD), impairs listening abilities supported by the use of two ears, including speech perception in background noise and sound localisation. Hearing-assistive devices can aid listen... Read More about Improving health-related quality of life in single-sided deafness: a systematic review and meta-analysis.