Outputs (135)

Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans (2017)
Journal Article
Valdes, A. M., Ravipati, S., Menni, C., Abhishek, A., Metrustry, S., Harris, J., Nessa, A., Williams, F. M., Spector, T. D., Doherty, M., Chapman, V., & Barrett, D. A. (in press). Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans. Scientific Reports, 7, Article 10748. https://doi.org/10.1038/s41598-017-09516-3

Resolvins are omega-3 fatty acid derived potent bioactive lipids that resolve inflammation and modulate transient receptor potential channels. Exogenous administration of the resolvin precursor 17-HDHA shows a strong analgesic effect in animal models... Read More about Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans.

The differential contribution of the innate immune system to a good pathological response in the breast and axillary lymph nodes induced by neoadjuvant chemotherapy in women with large and locally advanced breast cancers (2017)
Journal Article
Kaewkangsadan, V., Verma, C., Eremin, J. M., Cowley, G. P., Ilyas, M., Satthaporn, S., & Eremin, O. (2017). The differential contribution of the innate immune system to a good pathological response in the breast and axillary lymph nodes induced by neoadjuvant chemotherapy in women with large and locally advanced breast cancers. Journal of Immunology Research, 2017, Article 1049023. https://doi.org/10.1155/2017/1049023

The tumour microenvironment consists of malignant cells, stroma, and immune cells. The role of adaptive immunity in inducing a pathological complete response (pCR) in breast cancer with neoadjuvant chemotherapy (NAC) is well studied. The contribution... Read More about The differential contribution of the innate immune system to a good pathological response in the breast and axillary lymph nodes induced by neoadjuvant chemotherapy in women with large and locally advanced breast cancers.

Glargine and degludec: solution behaviour of higher dose synthetic insulins (2017)
Journal Article
Adams, G. G., Alzahrani, Q., Jiwani, S. I., Meal, A., Morgan, P. S., Coffey, F., Kok, S., Rowe, A. J., Harding, S. E., Chayen, N., & Gillis, R. B. (2017). Glargine and degludec: solution behaviour of higher dose synthetic insulins. Scientific Reports, 7(1), Article 7287. https://doi.org/10.1038/s41598-017-06642-w

Single, double and triple doses of the synthetic insulins glargine and degludec currently used in patient therapy are characterised using macromolecular hydrodynamic techniques (dynamic light scattering and analytical ultracentrifugation) in an attem... Read More about Glargine and degludec: solution behaviour of higher dose synthetic insulins.

Sexual offending hierarchies, personality attributions, and the clinical implications (2017)
Journal Article
Challinor, L. E., & Duff, S. (2017). Sexual offending hierarchies, personality attributions, and the clinical implications. Journal of Forensic Practice, 19(3), https://doi.org/10.1108/JFP-07-2016-0031

Aims: the research examines sexual offending hierarchies constructed by the general public and forensic staff based on personal attitudes and perceived severity of offence. In addition, six sexual offence perpetrators are differentiated using the Fiv... Read More about Sexual offending hierarchies, personality attributions, and the clinical implications.

Liver cirrhosis in England--an observational study: are we measuring its burden occurrence correctly? (2017)
Journal Article
Ratib, S., West, J., & Fleming, K. M. (2017). Liver cirrhosis in England--an observational study: are we measuring its burden occurrence correctly?. BMJ Open, 7(7), Article e013752. https://doi.org/10.1136/bmjopen-2016-013752

Objectives: Mortality due to liver disease (of which cirrhosis is the end‐stage) is increasing more than any other chronic condition in the UK. This study aims to demonstrate that (i) exclusive reliance on mortality rates may not reveal the true burd... Read More about Liver cirrhosis in England--an observational study: are we measuring its burden occurrence correctly?.

Integrative analysis of copy number and gene expression in breast cancer using formalin-fixed paraffin-embedded core biopsy tissue: a feasibility study (2017)
Journal Article
Iddawela, M., Rueda, O., Eremin, J., Eremin, O., Cowley, J., Earl, H. M., & Caldas, C. (in press). Integrative analysis of copy number and gene expression in breast cancer using formalin-fixed paraffin-embedded core biopsy tissue: a feasibility study. BMC Genomics, 18(1), https://doi.org/10.1186/s12864-017-3867-3

Background: An absence of reliable molecular markers has hampered individualised breast cancer treatments, and a major limitation for translational research is the lack of fresh tissue. There are, however, abundant banks of formalinfixed paraffin-emb... Read More about Integrative analysis of copy number and gene expression in breast cancer using formalin-fixed paraffin-embedded core biopsy tissue: a feasibility study.

Industrial survey of ISO surface texture parameters (2017)
Journal Article
Todhunter, L. D., Leach, R., Lawes, S., & Blateyron, F. (2017). Industrial survey of ISO surface texture parameters. CIRP Journal of Manufacturing Science and Technology, 19, https://doi.org/10.1016/j.cirpj.2017.06.001

Results of an international survey are presented, detailing the use of surface texture parameters in industry. The survey received 179 responses from a total of 34 countries, revealing the use of a variety of parameters from ISO 4287, ISO 12085, ISO... Read More about Industrial survey of ISO surface texture parameters.

The use of an online support group for neuromuscular disorders: a thematic analysis of message postings (2017)
Journal Article
Meade, O., Buchanan, H., & Coulson, N. S. (2018). The use of an online support group for neuromuscular disorders: a thematic analysis of message postings. Disability and Rehabilitation, 40(19), 2300-2310. https://doi.org/10.1080/09638288.2017.1334239

Purpose: People affected by neuromuscular disorders can experience adverse psychosocial consequences and difficulties accessing information and support. Online support groups provide new opportunities for peer support. The aim of this study was to un... Read More about The use of an online support group for neuromuscular disorders: a thematic analysis of message postings.

Screening for hepatocellular carcinoma: patient selection and perspectives (2017)
Journal Article
Fateen, W., & Ryder, S. (2017). Screening for hepatocellular carcinoma: patient selection and perspectives. Journal of Hepatocellular Carcinoma, 2017(4), https://doi.org/10.2147/JHC.S105777

Hepatocellular carcinoma (HCC) develops on the background of liver cirrhosis often from multiple, simultaneous factors. The diagnosis of a single small HCC comes with good prognosis and provides a potential for cure. In contrast, the diagnosis of mul... Read More about Screening for hepatocellular carcinoma: patient selection and perspectives.

Transcriptomic responses of mixed cultures of ascomycete fungi to lignocellulose using dual RNA-seq reveal inter-species antagonism and limited beneficial effects on CAZyme expression (2017)
Journal Article
Daly, P., van Munster, J. M., Kokolski, M., Sang, F., Blythe, M. J., Malla, S., Velasco de Castro Oliveira, J., Goldman, G. H., & Archer, D. B. (2017). Transcriptomic responses of mixed cultures of ascomycete fungi to lignocellulose using dual RNA-seq reveal inter-species antagonism and limited beneficial effects on CAZyme expression. Fungal Genetics and Biology, 102, https://doi.org/10.1016/j.fgb.2016.04.005

Gaining new knowledge through fungal monoculture responses to lignocellulose is a widely used approach that can lead to better cocktails for lignocellulose saccharification (the enzymatic release of sugars which are subsequently used to make biofuels... Read More about Transcriptomic responses of mixed cultures of ascomycete fungi to lignocellulose using dual RNA-seq reveal inter-species antagonism and limited beneficial effects on CAZyme expression.