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Welcome to Repository@Nottingham

The Repository@Nottingham is intended to be an Open Access showcase for the published research output of the university. Whenever possible, refereed documents accepted for publication, or finished artistic compositions presented in public, will be made available here in full digital format, and hyperlinks to standard published versions will be provided. See our Policies for further information.



Latest Additions

Defamilisation measures and women's labour force participation – a comparative study of twelve countries (2017)
Journal Article
Chau, R. C., Yu, S. W., Foster, L., & Lau, M. K. (2017). Defamilisation measures and women's labour force participation – a comparative study of twelve countries. Journal of International and Comparative Social Policy, 33(1), 73-86. https://doi.org/10.1080/21699763.2017.1288157

This paper examines the relevance of two interpretations of defamilisation (“freedom of the family” and “freedom of women from the family”) to the search for effective measures for strengthening women's participation in the paid labour market. Based... Read More about Defamilisation measures and women's labour force participation – a comparative study of twelve countries.

Simulating the influence of plasma protein on measured receptor affinity in biochemical assays reveals the utility of Schild analysis for estimating compound affinity for plasma proteins (2015)
Journal Article
Blakeley, D., Sykes, D. A., Ensor, P., Bertran, E., Aston, P. J., & Charlton, S. J. (2015). Simulating the influence of plasma protein on measured receptor affinity in biochemical assays reveals the utility of Schild analysis for estimating compound affinity for plasma proteins. British Journal of Pharmacology, 172(21), 5037-5049. https://doi.org/10.1111/bph.13263

© 2015 The British Pharmacological Society. Background and Purpose Plasma protein binding (PPB) influences the free fraction of drug available to bind to its target and is therefore an important consideration in drug discovery. While traditional meth... Read More about Simulating the influence of plasma protein on measured receptor affinity in biochemical assays reveals the utility of Schild analysis for estimating compound affinity for plasma proteins.

Defamilisation and leave policies -a comparative study of 14 East Asian and non-East Asian countries (2017)
Journal Article
Chau, R. C., Foster, L., & Yu, S. W. (2017). Defamilisation and leave policies -a comparative study of 14 East Asian and non-East Asian countries. Journal of Asian Public Policy, 10(3), 318-333. https://doi.org/10.1080/17516234.2017.1322286

This article joins the international debate on whether there is a unique East Asian welfare model. It examines the concept of defamilisation and compares various leave policies (maternity leave, paternity leave and extended parental leave) in five Ea... Read More about Defamilisation and leave policies -a comparative study of 14 East Asian and non-East Asian countries.

Fevipiprant (QAW039), a slowly dissociating CRTh2 antagonist with the potential for improved clinical efficacy (2016)
Journal Article
Sykes, D. A., Bradley, M. E., Riddy, D. M., Willard, E., Reilly, J., Miah, A., …Charlton, S. J. (2016). Fevipiprant (QAW039), a slowly dissociating CRTh2 antagonist with the potential for improved clinical efficacy. Molecular Pharmacology, 89(5), 593-605. https://doi.org/10.1124/mol.115.101832

Here we describe the pharmacologic properties of a series of clinically relevant chemoattractant receptor-homologous molecules expressed on T-helper type 2 (CRTh2) receptor antagonists, including fevipiprant (NVP-QAW039 or QAW039), which is currently... Read More about Fevipiprant (QAW039), a slowly dissociating CRTh2 antagonist with the potential for improved clinical efficacy.