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Dually Labeled Neurotensin NTS1R Ligands for Probing Radiochemical and Fluorescence-Based Binding Assays (2024)
Journal Article
Ertl, F. J., Kopanchuk, S., Dijon, N. C., Veikšina, S., Tahk, M.-J., Laasfeld, T., Schettler, F., Gattor, A. O., Hübner, H., Archipowa, N., Köckenberger, J., Heinrich, M. R., Gmeiner, P., Kutta, R. J., Holliday, N. D., Rinken, A., & Keller, M. (in press). Dually Labeled Neurotensin NTS1R Ligands for Probing Radiochemical and Fluorescence-Based Binding Assays. Journal of Medicinal Chemistry, https://doi.org/10.1021/acs.jmedchem.4c01470

The determination of ligand–receptor binding affinities plays a key role in the development process of pharmaceuticals. While the classical radiochemical binding assay uses radioligands, fluorescence-based binding assays require fluorescent probes. U... Read More about Dually Labeled Neurotensin NTS1R Ligands for Probing Radiochemical and Fluorescence-Based Binding Assays.

Developing a process for assessing the safety of a digital mental health intervention and gaining regulatory approval: a case study and academic’s guide (2024)
Journal Article
Taher, R., Hall, C. L., Gomez Bergin, A. D., Gupta, N., Heaysman, C., Jacobsen, P., Kabir, T., Kalnad, N., Keppens, J., Hsu, C.-W., McGuire, P., Peters, E., Shergill, S., Stahl, D., Wensley Stock, B., & Yiend, J. (2024). Developing a process for assessing the safety of a digital mental health intervention and gaining regulatory approval: a case study and academic’s guide. Trials, 25, Article 604. https://doi.org/10.1186/s13063-024-08421-1

Background: The field of digital mental health has followed an exponential growth trajectory in recent years. While the evidence base has increased significantly, its adoption within health and care services has been slowed by several challenges, inc... Read More about Developing a process for assessing the safety of a digital mental health intervention and gaining regulatory approval: a case study and academic’s guide.

Marine mammals as indicators of Anthropocene Ocean Health (2024)
Journal Article
Plön, S., Andra, K., Auditore, L., Gegout, C., Hale, P. J., Hampe, O., Ramilo-Henry, M., Burkhardt-Holm, P., Jaigirdar, A. M., Klein, L., Maewashe, M. K., Müssig, J., Ramsarup, N., Roussouw, N., Sabin, R., Shongwe, T. C., & Tuddenham, P. (2024). Marine mammals as indicators of Anthropocene Ocean Health. npj Biodiversity, 3(1), Article 24. https://doi.org/10.1038/s44185-024-00055-5

The current state of marine mammal populations reflects increasing anthropogenic impacts on the global Ocean. Adopting a holistic approach towards marine mammal health, incorporating healthy individuals and healthy populations, these taxa present ind... Read More about Marine mammals as indicators of Anthropocene Ocean Health.

Theoretical Study on the Biosynthesis of the Mandapamates: Mechanistic Insights Using Density Functional Theory (2024)
Journal Article
Wang, D., Pattenden, G., Fow, K. L., Stocks, M. J., Hirst, J. D., & Tang, B. (2024). Theoretical Study on the Biosynthesis of the Mandapamates: Mechanistic Insights Using Density Functional Theory. Journal of Organic Chemistry, https://doi.org/10.1021/acs.joc.4c00859

Density functional theory (B3LYP-D3(BJ) and ωB97XD) calculations have been used to assess the stereochemical outcomes of the proposed transannular [4 + 2] cycloaddition pathway for the biosynthesis of mandapamate and isomandapamate from macrocyclic i... Read More about Theoretical Study on the Biosynthesis of the Mandapamates: Mechanistic Insights Using Density Functional Theory.

Parenting in a changing climate: the relationship between talking to children aged 5-11 about climate change, family eco-behaviours and climate change anxiety (2024)
Journal Article
Jackson, J., Rawson, R., Colman, R., Kotero, Y., & Brooks-Ucheaga, M. (2024). Parenting in a changing climate: the relationship between talking to children aged 5-11 about climate change, family eco-behaviours and climate change anxiety. Global Health Economics and Sustainability, 2(3), Article 3172. https://doi.org/10.36922/ghes.3172

Climate change has a substantial impact on human health and the increased symptoms of climate change anxiety have led to a global call for action. However, data exploring the relationship between climate change, mental health, and individuals with pa... Read More about Parenting in a changing climate: the relationship between talking to children aged 5-11 about climate change, family eco-behaviours and climate change anxiety.

Research into digital health intervention for mental health: a 25-year retrospective on the ethical and legal challenges (2024)
Journal Article
Hall, C. L., Gómez Bergin, A. D., & Rennick-Egglestone, S. (2024). Research into digital health intervention for mental health: a 25-year retrospective on the ethical and legal challenges. Journal of Medical Internet Research, 26, Article e58939. https://doi.org/10.2196/58939

Digital mental health interventions are routinely integrated into mental health services internationally, and can contribute to the reduction of the global mental health treatment gap that has been identified by the World Health Organisation. Researc... Read More about Research into digital health intervention for mental health: a 25-year retrospective on the ethical and legal challenges.

Health outcomes 3 months and 6 months after molnupiravir treatment for COVID-19 for people at higher risk in the community (PANORAMIC): a randomised controlled trial (2024)
Journal Article
Harris, V., Holmes, J., Gbinigie, O., Rahman, N. M., Richards, D. B., Hayward, G., Dorward, J., Lowe, D. M., Standing, J. F., Breuer, J., Khoo, S., Petrou, S., Hood, K., Ahmed, H., Carson-Stevens, A., Nguyen-Van-Tam, J. S., Patel, M. G., Saville, B. R., Francis, N., Thomas, N. P. B., …Butler, C. C. (2024). Health outcomes 3 months and 6 months after molnupiravir treatment for COVID-19 for people at higher risk in the community (PANORAMIC): a randomised controlled trial. Lancet Infectious Diseases, https://doi.org/10.1016/S1473-3099%2824%2900431-6

Background
No randomised controlled trials have yet reported on the effectiveness of molnupiravir on longer term outcomes for COVID-19. The PANORAMIC trial found molnupiravir reduced time to recovery in acute COVID-19 over 28 days. We aimed to repor... Read More about Health outcomes 3 months and 6 months after molnupiravir treatment for COVID-19 for people at higher risk in the community (PANORAMIC): a randomised controlled trial.

Paving the road while walking -perspectives from Flexible Assertive Community Treatment managers on preparing the implementation of peer support work in Outpatient Services (2024)
Journal Article
Johansen, K. K., Lerbaek, B., Slade, M., Castelein, S., & Jørgensen, R. (2024). Paving the road while walking -perspectives from Flexible Assertive Community Treatment managers on preparing the implementation of peer support work in Outpatient Services. Issues in Mental Health Nursing, https://doi.org/10.1080/01612840.2024.2391848

This qualitative study explored the perspectives of Flexible Assertive Community Treatment managers on preparation and employment of peer support workers. The study was based on semi-structured interviews with managers (n = 5) in Outpatient Services... Read More about Paving the road while walking -perspectives from Flexible Assertive Community Treatment managers on preparing the implementation of peer support work in Outpatient Services.

Primary liver cancer risk and mortality in patients with alcohol-related cirrhosis in England and Denmark: observational cohort studies (2024)
Journal Article
Jensen, M. D., West, J., Crooks, C., Morling, J. R., Kraglund, F., Card, T., Askgaard, G., & Jepsen, P. (2024). Primary liver cancer risk and mortality in patients with alcohol-related cirrhosis in England and Denmark: observational cohort studies. American Journal of Gastroenterology, https://doi.org/10.14309/ajg.0000000000003077

Background & Aims:

Patients with alcohol-related cirrhosis (ALD cirrhosis) have an increased risk of primary liver cancer (hepatocellular carcinoma [HCC] or intrahepatic cholangiocarcinoma [iCCA]). England recommends surveillance for HCC in these... Read More about Primary liver cancer risk and mortality in patients with alcohol-related cirrhosis in England and Denmark: observational cohort studies.

Cannabidiol and fluorinated derivative anti-cancer properties against glioblastoma multiforme cell lines, and synergy with imidazotetrazine agents (2024)
Journal Article
Brookes, A., Kindon, N., Scurr, D. J., Alexander, M. R., Gershkovich, P., & Bradshaw, T. (2024). Cannabidiol and fluorinated derivative anti-cancer properties against glioblastoma multiforme cell lines, and synergy with imidazotetrazine agents. BJC Reports, 2, Article 67. https://doi.org/10.1038/s44276-024-00088-0

Background
Glioblastoma multiforme (GBM) is an aggressive cancer with poor prognosis, partly due to resistance to the standard chemotherapy treatment, temozolomide (TMZ). Phytocannabinoid cannabidiol (CBD) has exhibited anti-cancer effects against G... Read More about Cannabidiol and fluorinated derivative anti-cancer properties against glioblastoma multiforme cell lines, and synergy with imidazotetrazine agents.

Exploring general practitioners’ management of self-harm in young people: a qualitative study (2024)
Journal Article
Mughal, F., Saunders, B., Lewis, M., Armitage, C., Dikomitis, L., Lancaster, G., Townsend, E., & Chew-Graham, C. A. (2024). Exploring general practitioners’ management of self-harm in young people: a qualitative study. Health Expectations, 27(5), Article e70026. https://doi.org/10.1111/hex.70026

Background
General practitioners (GPs) are key to the frontline assessment and treatment of young people after self-harm. Young people value GP-led self-harm care but little is known about how GPs manage young people after self-harm.

Aim
To und... Read More about Exploring general practitioners’ management of self-harm in young people: a qualitative study.

Not always as advertised: Different effects from viewing safer gambling (harm prevention) adverts on gambling urges (2024)
Journal Article
Newall, P., Weiss-Cohen, L., Torrance, J., & Bart, Y. (2025). Not always as advertised: Different effects from viewing safer gambling (harm prevention) adverts on gambling urges. Addictive Behaviors, 160, Article 108161. https://doi.org/10.1016/j.addbeh.2024.108161

Public concern around gambling advertising in the UK has been met not by government action but by industry self-regulations, such as a forthcoming voluntary ban on front-of-shirt gambling sponsorship in Premier League soccer. “Safer gambling” (harm p... Read More about Not always as advertised: Different effects from viewing safer gambling (harm prevention) adverts on gambling urges.

LES informed data-driven models for RANS simulations of single-hole cooling flows (2024)
Journal Article
Ellis, C. D., & Xia, H. (2024). LES informed data-driven models for RANS simulations of single-hole cooling flows. International Journal of Heat and Mass Transfer, 235, Article 126150. https://doi.org/10.1016/j.ijheatmasstransfer.2024.126150

A LES-informed data-driven approach for improved predictions of the turbulent heat flux vector has been sought for film and effusion cooling flow applications. Random forest and shallow neural networks have been used to train a spatially varying coef... Read More about LES informed data-driven models for RANS simulations of single-hole cooling flows.

Using online methods to recruit participants into mental health clinical trials: considerations and recommendations from the RE-MIND study (2024)
Journal Article
Iflaifel, M., Hall, C. L., Green, H. R., Willis, A., Rennick-Egglestone, S., Juszczak, E., Townsend, M., Martin, J., & Sprange, K. (2024). Using online methods to recruit participants into mental health clinical trials: considerations and recommendations from the RE-MIND study. Trials, 25, Article 596. https://doi.org/10.1186/s13063-024-08435-9

Background: Ensuring diversity in clinical trials can be a challenge, which may be exacerbated when recruiting vulnerable populations, such as participants with mental health illness. As recruitment continues to be the major cause of trial delays, re... Read More about Using online methods to recruit participants into mental health clinical trials: considerations and recommendations from the RE-MIND study.

To cut or not to cut: Deforestation policy under the shadow of foreign influence (2024)
Journal Article
Aidt, T. S., Albornoz, F., & Hauk, E. (2024). To cut or not to cut: Deforestation policy under the shadow of foreign influence. Journal of Economic Behavior and Organization, 227, Article 106712

This article explores the complex interplay between deforestation policies and foreign influence, using a game theoretical model to analyze geopolitical factors influencing forest conservation decisions in countries with significant rainforests. The... Read More about To cut or not to cut: Deforestation policy under the shadow of foreign influence.

Engaging low-income families in education research: examining the challenges in Beijing and London (2024)
Journal Article
Hoskins, K., Wainwright, E., Arabaci, R., Zhai, J., Gao, J., & XU, Y. (in press). Engaging low-income families in education research: examining the challenges in Beijing and London. Compare: A Journal of Comparative and International Education,

This comparative paper considers the similar challenges encountered in Beijing (China) and Greater London (England) when engaging low-income families in education research. Through semi-structured interviews with 10 parents/caregivers in Beijing and... Read More about Engaging low-income families in education research: examining the challenges in Beijing and London.

The Memory in Return Volatility: An Analysis of Mutual Fund Returns (2024)
Journal Article
Yao, K., Duan, K., Huang, R., & Chevapatrakul, T. (in press). The Memory in Return Volatility: An Analysis of Mutual Fund Returns. International Journal of Finance and Economics,

This paper examines long memory in the return volatility in the cross-section of U.S. mutual funds. Our results provide evidence of this phenomenon. Through univariate analysis, we find that the long memory in mutual fund return volatility is more pr... Read More about The Memory in Return Volatility: An Analysis of Mutual Fund Returns.