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Metabolomic and Proteomic Analysis of ApoE4-Carrying H4 Neuroglioma Cells in Alzheimer’s Disease Using OrbiSIMS and LC-MS/MS (2024)
Journal Article
Lu, L., Kotowska, A. M., Kern, S., Fang, M., Rudd, T. R., Alexander, M. R., Scurr, D. J., & Zhu, Z. (2024). Metabolomic and Proteomic Analysis of ApoE4-Carrying H4 Neuroglioma Cells in Alzheimer’s Disease Using OrbiSIMS and LC-MS/MS. Analytical Chemistry, https://doi.org/10.1021/acs.analchem.4c01201

Growing clinical evidence reveals that systematic molecular alterations in the brain occur 20 years before the onset of AD pathological features. Apolipoprotein E4 (ApoE4) is one of the most significant genetic risk factors for Alzheimer’s disease (A... Read More about Metabolomic and Proteomic Analysis of ApoE4-Carrying H4 Neuroglioma Cells in Alzheimer’s Disease Using OrbiSIMS and LC-MS/MS.

Maternal selenium deficiency was positively associated with the risk of selenium deficiency in children aged 6–59 months in rural Zimbabwe (2024)
Journal Article
Mutonhodza, B., Manzeke-Kangara, M. G., Bailey, E. H., Matsungo, T. M., & Chopera, P. (2024). Maternal selenium deficiency was positively associated with the risk of selenium deficiency in children aged 6–59 months in rural Zimbabwe. PLOS Global Public Health, 4(7), Article e0003376. https://doi.org/10.1371/journal.pgph.0003376

There is growing evidence showing the existence of selenium (Se) deficiency among women and children in sub-Saharan Africa. Unfortunately, the key drivers of Se deficiency are not clearly understood. This study assessed the determinants of Se deficie... Read More about Maternal selenium deficiency was positively associated with the risk of selenium deficiency in children aged 6–59 months in rural Zimbabwe.

Guidelines Peri-operative pain management in adults: a multidisciplinary consensus statement from the Association of Anaesthetists and the British Pain Society (2024)
Journal Article
El-Boghdadly, K., Levy, N. A., Fawcett, W. J., Knaggs, R. D., Laycock, H., Baird, E., Cox, F. J., Eardley, W., Kemp, H., Malpus, Z., Partridge, A., Partridge, J., Patel, A., Price, C., Robinson, J., Russon, K., Walumbe, J., & Lobo, D. N. (in press). Guidelines Peri-operative pain management in adults: a multidisciplinary consensus statement from the Association of Anaesthetists and the British Pain Society. Anaesthesia,

This is a consensus document produced by expert members of a Working Party established by the Association of Anaesthetists and the British Pain Society. It has been seen and approved by their Committee and Board respectively. It is supported by the E... Read More about Guidelines Peri-operative pain management in adults: a multidisciplinary consensus statement from the Association of Anaesthetists and the British Pain Society.

Phase and amplitude responses for delay equations using harmonic balance (2024)
Journal Article
Nicks, R., Allen, R., & Coombes, S. (2024). Phase and amplitude responses for delay equations using harmonic balance. Physical Review E, 110(1), Article L012202. https://doi.org/10.1103/PhysRevE.110.L012202

Robust delay induced oscillations, common in nature, are often modeled by delay-differential equations (DDEs). Motivated by the success of phase-amplitude reductions for ordinary differential equations with limit cycle oscillations, there is now a gr... Read More about Phase and amplitude responses for delay equations using harmonic balance.

Loan guarantees and SMEs' investments under asymmetric information and Bayesian learning (2024)
Journal Article
Luo, P., Wang, H., & Yang, Z. (2024). Loan guarantees and SMEs' investments under asymmetric information and Bayesian learning. Journal of Risk and Insurance, https://doi.org/10.1111/jori.12485

We develop a dynamic investment model with loan guarantees wherein insurers face information disadvantages and learn about borrower quality. Borrowers signal their qualities through investment timing, which is characterized by the investment threshol... Read More about Loan guarantees and SMEs' investments under asymmetric information and Bayesian learning.

Work-related smartphone use during off-job hours and work-life conflict: a scoping review (2024)
Journal Article
Blake, H., Hassard, J., Singh, J., & Teoh, K. (in press). Work-related smartphone use during off-job hours and work-life conflict: a scoping review. PLOS Digital Health,

Over recent decades the use of smartphones for work purposes has burgeoned both within and beyond working hours. The aim of the study was to conduct a scoping review to explore the association between the use of smartphone technology for work purpose... Read More about Work-related smartphone use during off-job hours and work-life conflict: a scoping review.

Line manager training and organisational approaches to supporting wellbeing (2024)
Journal Article
Dulal-Arthur, T., Hassard, J., Bourke, J., Roper, S., Wishart, M., Belt, V., Bartle, C., Leka, S., Pahl, N., Thomson, L., & Blake, H. (2024). Line manager training and organisational approaches to supporting wellbeing. Occupational Medicine, https://doi.org/10.1093/occmed/kqae051

Background Employee mental health and well-being (MH&WB) is critical to the productivity and success of organizations. Training line managers (LMs) in mental health plays an important role in protecting and enhancing employee well-being, but its rel... Read More about Line manager training and organisational approaches to supporting wellbeing.

Self-similarity and limit spaces of substitution tiling semigroups (2024)
Journal Article
Walton, J., & Whittaker, M. F. (2024). Self-similarity and limit spaces of substitution tiling semigroups. Groups, Geometry, and Dynamics, https://doi.org/10.4171/GGD/807

We show that Kellendonk's tiling semigroup of an FLC substitution tiling is self-similar, in the sense of Bartholdi, Grigorchuk and Nekrashevych. We extend the notion of the limit space of a self-similar group to the setting of self-similar semigroup... Read More about Self-similarity and limit spaces of substitution tiling semigroups.

Improving the Development and Reusability of Industrial AI Through Semantic Models (2024)
Presentation / Conference Contribution
Martínez-Arellano, G., & Ratchev, S. (2024, April). Improving the Development and Reusability of Industrial AI Through Semantic Models. Presented at Conference on Learning Factories 2024, University of Twente, The Netherlands

Despite some of the success of AI, particularly machine learning, in industrial applications such as condition monitoring, quality inspection and asset control , solutions are typically bespoke and not robust in the long term. There is a considerable... Read More about Improving the Development and Reusability of Industrial AI Through Semantic Models.

The Passion of the Rabbit God (2024)
Book
Bao, H. (2024). The Passion of the Rabbit God. Valley Press

Hongwei Bao’s debut collection charts an emotional journey through centuries and between nations, with the poet’s own migration from Inner Mongolia to Nottingham offering a unique, fascinating perspective through which to examine Asian and queer iden... Read More about The Passion of the Rabbit God.

The Lyman-limit photon mean free path at the end of late reionization in the Sherwood–Relics simulations (2024)
Journal Article
Feron, J., Conaboy, L., Bolton, J. S., Chapman, E., Haehnelt, M. G., Keating, L. C., Kulkarni, G., & Puchwein, E. (2024). The Lyman-limit photon mean free path at the end of late reionization in the Sherwood–Relics simulations. Monthly Notices of the Royal Astronomical Society, 532(2), 2401-2417. https://doi.org/10.1093/mnras/stae1636

Recent evidence supporting reionization ending at redshift z ≲ 6 includes the rapid redshift evolution of the mean free path, λmfp , for Lyman-limit photons through the intergalactic medium (IGM) at 5 < z < 6. Here, we investigate λmfp predicted by t... Read More about The Lyman-limit photon mean free path at the end of late reionization in the Sherwood–Relics simulations.

Assessing correlations between two linear amplitude sweep (LAS) standards for evaluating the fatigue properties of aged bitumen (2024)
Journal Article
Hu, Y., Sreeram, A., Bahia, H. U., Airey, G. D., Si, W., Li, B., & Xu, X. (2024). Assessing correlations between two linear amplitude sweep (LAS) standards for evaluating the fatigue properties of aged bitumen. International Journal of Pavement Engineering, 25(1), Article 2375419. https://doi.org/10.1080/10298436.2024.2375419

Linear amplitude sweep (LAS) is an accelerated and well-established testing method to evaluate bitumen fatigue. However, there are different versions of LAS procedures employed. Significant differences in loading modes, damage failure criteria and ca... Read More about Assessing correlations between two linear amplitude sweep (LAS) standards for evaluating the fatigue properties of aged bitumen.

Identification of Predictive Biomarkers of Lameness in Transition Dairy Cows (2024)
Journal Article
Cardoso, A. S., Whitby, A., Green, M. J., Kim, D.-H., & Randall, L. V. (2024). Identification of Predictive Biomarkers of Lameness in Transition Dairy Cows. Animals, 14(14), Article 2030. https://doi.org/10.3390/ani14142030

The aim of this study was to identify with a high level of confidence metabolites previously identified as predictors of lameness and understand their biological relevance by carrying out pathway analyses. For the dairy cattle sector, lameness is a m... Read More about Identification of Predictive Biomarkers of Lameness in Transition Dairy Cows.

A Review of Thermochemical Energy Storage Systems for District Heating in the UK (2024)
Journal Article
Roger-Lund, S., Darkwa, J., Worall, M., Calautit, J., & Boukhanouf, R. (2024). A Review of Thermochemical Energy Storage Systems for District Heating in the UK. Energies, 17(14), Article 3389. https://doi.org/10.3390/en17143389

Thermochemical energy storage (TCES) presents a promising method for energy storage due to its high storage density and capacity for long-term storage. A combination of TCES and district heating networks exhibits an appealing alternative to natural g... Read More about A Review of Thermochemical Energy Storage Systems for District Heating in the UK.

Classification of osteoarthritic and healthy cartilage using deep learning with Raman spectra (2024)
Journal Article
Kok, Y. E., Crisford, A., Parkes, A., Venkateswaran, S., Oreffo, R., Mahajan, S., & Pound, M. (2024). Classification of osteoarthritic and healthy cartilage using deep learning with Raman spectra. Scientific Reports, 14(1), Article 15902. https://doi.org/10.1038/s41598-024-66857-6

Raman spectroscopy is a rapid method for analysing the molecular composition of biological material. However, noise contamination in the spectral data necessitates careful pre-processing prior to analysis. Here we propose an end-to-end Convolutional... Read More about Classification of osteoarthritic and healthy cartilage using deep learning with Raman spectra.

β-glycerophosphate, not low magnitude fluid shear stress, increases osteocytogenesis in the osteoblast-to-osteocyte cell line IDG-SW3 (2024)
Journal Article
Owen, R., Wittkowske, C., Lacroix, D., Perrault, C. M., & Reilly, G. C. (2024). β-glycerophosphate, not low magnitude fluid shear stress, increases osteocytogenesis in the osteoblast-to-osteocyte cell line IDG-SW3. Connective Tissue Research, https://doi.org/10.1080/03008207.2024.2375065

Aim As osteoblasts deposit a mineralized collagen network, a subpopulation of these cells differentiates into osteocytes. Biochemical and mechanical stimuli, particularly fluid shear stress (FSS), are thought to regulate this, but their relative inf... Read More about β-glycerophosphate, not low magnitude fluid shear stress, increases osteocytogenesis in the osteoblast-to-osteocyte cell line IDG-SW3.

Evaluation of the mechanism of action of paracetamol, drotaverine, and peppermint oil and their effects in combination with hyoscine butylbromide on colonic motility: Human ex-vivo study (2024)
Journal Article
Traserra, S., Barber, C., Gerardo Alcalá-González, L., Landolfi, S., Lange, R., Malagelada, C., …Jimenez, M. (2024). Evaluation of the mechanism of action of paracetamol, drotaverine, and peppermint oil and their effects in combination with hyoscine butylbromide on colonic motility: Human ex-vivo study. Frontiers in Pharmacology, 15, Article 1384070. https://doi.org/10.3389/fphar.2024.1384070

Introduction: Drotaverine, paracetamol, and peppermint oil are often prescribed for the treatment of gastrointestinal spasm and pain. This study aimed to evaluate the effect of these drugs alone and combined with the well-known antispasmodic hyoscine... Read More about Evaluation of the mechanism of action of paracetamol, drotaverine, and peppermint oil and their effects in combination with hyoscine butylbromide on colonic motility: Human ex-vivo study.

Metaethics and the Nature of Properties (2024)
Journal Article
Sinclair, N. (2024). Metaethics and the Nature of Properties. Aristotelian Society Supplementary Volume, 98(1), 133-152. https://doi.org/10.1093/arisup/akae004

This paper explores connections between theories of morality and theories of properties. It argues that (1) moral realism is in tension with predicate, class and mereological nominalism; (2) moral non-naturalism is incompatible with standard versions... Read More about Metaethics and the Nature of Properties.

Development of a Vocational Rehabilitation Intervention to support Return to Work and Wellbeing following Major Trauma: A Person-Based Approach (2024)
Journal Article
Radford, K., Kettlewell, J., das Nair, R., Morriss, R., Holmes, J., Kellezi, B., Timmons, S., Jones, T., Tressider, H., Andrews, I., Bridger, K., Patel, P., Lindley, R., De Dios Perez, B., Statham, A., Jones, T., Hoffman, K., James, M., Kendrick, D., & ROWTATE study team. (in press). Development of a Vocational Rehabilitation Intervention to support Return to Work and Wellbeing following Major Trauma: A Person-Based Approach. BMJ Open,

Objectives: Major trauma centres save lives but rehabilitation to support return-to-work (RTW) is lacking. This paper describes development of a vocational rehabilitation intervention (the ROWTATE intervention) to support RTW following traumatic inju... Read More about Development of a Vocational Rehabilitation Intervention to support Return to Work and Wellbeing following Major Trauma: A Person-Based Approach.