All Outputs (44771)

Discovery of MT-1207: A Novel, Potent Multitarget Inhibitor as a Promising Clinical Candidate for the Treatment of Hypertension (2024)
Journal Article
Wang, P., Zhu, H., Tian, J.-S., Zhu, W., Xu, S., Yao, H., Liu, J., Zhu, Z., Miao, C.-Y., & Xu, J. (2024). Discovery of MT-1207: A Novel, Potent Multitarget Inhibitor as a Promising Clinical Candidate for the Treatment of Hypertension. Journal of Medicinal Chemistry, https://doi.org/10.1021/acs.jmedchem.4c00626

Herein, a series of novel arylpiperazine (piperidine) derivatives were designed, synthesized, and evaluated for mechanisms of action through in vitro and in vivo studies. The most promising compound, II-13 (later named as MT-1207), is a potent α1 and... Read More about Discovery of MT-1207: A Novel, Potent Multitarget Inhibitor as a Promising Clinical Candidate for the Treatment of Hypertension.

Reconceiving Domestic Burning Controls: Air Quality Alerts, Behavioural Responsive Regulation, and Designing for Compliance (2024)
Journal Article
Heydon, J., Chakraborty, R., Patel, V., Wood, C., Wood, M., & Bunce, C. (in press). Reconceiving Domestic Burning Controls: Air Quality Alerts, Behavioural Responsive Regulation, and Designing for Compliance. Environmental Management,

Domestic combustion emissions pose a growing risk to public health, especially in the UK. Existing responses are polarised, with government advocating use of lower emission fuels and stoves while clean air campaigners call for blanket bans on burning... Read More about Reconceiving Domestic Burning Controls: Air Quality Alerts, Behavioural Responsive Regulation, and Designing for Compliance.

Redox Materials for Electrochemical Capacitors (2024)
Journal Article
Chiku, M., Abdollahifar, M., Brousse, T., Chen, G. Z., Crosnier, O., Dunn, B., Fic, K., Hu, C.-C., Jeżowski, P., Maćkowiak, A., Naoi, K., Ogihara, N., Okita, N., Okubo, M., Sugimoto, W., & Wu, N.-L. (2024). Redox Materials for Electrochemical Capacitors. Electrochemistry, Article 24-70054. https://doi.org/10.5796/electrochemistry.24-70054

Electrochemical capacitors are known for their high power density and cyclability, and various redox reactions can be utilized to improve their energy density. A great variety of redox materials have been investigated recently for use in electrochemi... Read More about Redox Materials for Electrochemical Capacitors.

Researching the everyday educational lives of low-income families: the importance of researcher and participant contexts (2024)
Journal Article
Wainwright, E., Hoskins, K., Arabaci, R., Zhai, J., Gao, J., & XU, Y. (in press). Researching the everyday educational lives of low-income families: the importance of researcher and participant contexts. British Journal of Educational Studies,

This paper highlights the importance of considering both researcher and participant contexts when exploring everyday educational lives. It emerges during a period of increasing and sustained social inequality in England, and against a backdrop of inc... Read More about Researching the everyday educational lives of low-income families: the importance of researcher and participant contexts.

Cellular and microenvironmental cues that promote macrophage fusion and foreign body response (2024)
Journal Article
Stewart, C. L., Marlow, M., Zelzer, M., Hook, A. L., & Piccinini, A. M. (in press). Cellular and microenvironmental cues that promote macrophage fusion and foreign body response. Frontiers in Immunology, 15, https://doi.org/10.3389/fimmu.2024.1411872

During the foreign body response (FBR), macrophages fuse to form foreign body giant cells (FBGCs). Modulation of FBGC formation can prevent biomaterial degradation and loss of therapeutic efficacy. However, the microenvironmental cues that dictate FB... Read More about Cellular and microenvironmental cues that promote macrophage fusion and foreign body response.

Bond behaviour of prestressed basalt textile reinforced concrete (2024)
Journal Article
Hutaibat, M., Ghiassi, B., & Tizani, W. (2024). Bond behaviour of prestressed basalt textile reinforced concrete. Construction and Building Materials, 438, Article 137309. https://doi.org/10.1016/j.conbuildmat.2024.137309

Innovative Textile Reinforced Concrete (TRC) composites, although holding a significant potential, usually have poor performance under serviceability conditions. Addressing this limitation requires applying innovative techniques, such as prestressing... Read More about Bond behaviour of prestressed basalt textile reinforced concrete.

How does viewing angle affect the perceived accuracy of Batesian mimicry in hoverflies? (2024)
Journal Article
Baker, L., Taylor, C., Gilbert, F., & Reader, T. (2024). How does viewing angle affect the perceived accuracy of Batesian mimicry in hoverflies?. Behavioral Ecology, 35(5), Article arae054. https://doi.org/10.1093/beheco/arae054

Despite Batesian mimicry often eliciting predator avoidance, many Batesian mimics, such as some species of hoverfly (Syrphidae), are considered to have an “imperfect” resemblance to their model. One possible explanation for the persistence of apparen... Read More about How does viewing angle affect the perceived accuracy of Batesian mimicry in hoverflies?.

Life cycle assessment of pavement construction: A case study (2024)
Presentation / Conference Contribution
Koh, D., Tokbolat, S., & Blaauw, S. A. (2024, June). Life cycle assessment of pavement construction: A case study. Presented at World Sustainable Built Environment 2024 (WSBE24), Online

Road construction is often associated with carbon emissions from direct and indirect sources, primarily due to construction and maintenance activities. Currently, there is a lack of comprehensive Life Cycle Assessment (LCA) benchmarks to evaluate fle... Read More about Life cycle assessment of pavement construction: A case study.

Exposure to blue light reduces antimicrobial resistant Pseudomonas aeruginosa isolated from dog ear infections (2024)
Journal Article
Gigante, A. M., Hadis, M. A., Secker, B., Shaw, S., Cooper, P. R., Palin, W. M., …Atterbury, R. J. (2024). Exposure to blue light reduces antimicrobial resistant Pseudomonas aeruginosa isolated from dog ear infections. Frontiers in Microbiology, 15, 1-11. https://doi.org/10.3389/fmicb.2024.1414412

Introduction: Pseudomonas aeruginosa is a leading cause of canine otitis externa. Enrofloxacin is often applied topically to treat this condition, although recalcitrant and recurring infections are common. There is evidence that exposure to blue ligh... Read More about Exposure to blue light reduces antimicrobial resistant Pseudomonas aeruginosa isolated from dog ear infections.

Policy Brief: Autism and Suicide Prevention (2024)
Report
Cassidy, S., Newell, V., & Adams, J. (2024). Policy Brief: Autism and Suicide Prevention. University of Nottingham

More than one in 100 people in the UK are autistic. Yet, autistic people are not always supported, or accepted, by society. There is a considerably increased risk of suicide in autistic people compared to non-autistic people. Suicide rates in t... Read More about Policy Brief: Autism and Suicide Prevention.

Local learning landscapes: conceptualising place-based professional learning by teachers and schools in decentralised education systems (2024)
Journal Article
Greany, T., Cowhitt, T., Noyes, A., Gripton, C., & Hudson, G. (2024). Local learning landscapes: conceptualising place-based professional learning by teachers and schools in decentralised education systems. Journal of Educational Change, https://doi.org/10.1007/s10833-024-09508-x

This article sets out an original conceptual framework for place-based professional learning by teachers and schools in decentralised education systems. High quality Continuing Professional Development and Learning (CDPL) by teachers is associated wi... Read More about Local learning landscapes: conceptualising place-based professional learning by teachers and schools in decentralised education systems.

Reviewing the Spectral Variation Hypothesis: Twenty years in the tumultuous sea of biodiversity estimation by remote sensing (2024)
Journal Article
Torresani, M., Rossi, C., Perrone, M., Hauser, L. T., Féret, J.-B., Moudrý, V., Simova, P., Ricotta, C., Foody, G. M., Kacic, P., Feilhauer, H., Malavasi, M., Tognetti, R., & Rocchini, D. (2024). Reviewing the Spectral Variation Hypothesis: Twenty years in the tumultuous sea of biodiversity estimation by remote sensing. Ecological Informatics, 82, Article 102702. https://doi.org/10.1016/j.ecoinf.2024.102702

Twenty years ago, the Spectral Variation Hypothesis (SVH) was formulated as a means to link between different aspects of biodiversity and spatial patterns of spectral data (e.g. reflectance) measured from optical remote sensing. This hypothesis initi... Read More about Reviewing the Spectral Variation Hypothesis: Twenty years in the tumultuous sea of biodiversity estimation by remote sensing.

AFPM Machines Equipped with Multilayer Magnets (2024)
Journal Article
Darmani, M. A., Pošković, E., Franchini, F., Ferraris, L., Cavagnino, A., & Gerada, C. (2024). AFPM Machines Equipped with Multilayer Magnets. IEEE Transactions on Energy Conversion, https://doi.org/10.1109/tec.2024.3420133

This article investigates the manufacturability and applicability of unified multilayer magnets, comprising two different magnetic materials with distinct characteristics, for use in electrical machines. In particular, the self-produced multilayer ma... Read More about AFPM Machines Equipped with Multilayer Magnets.

Particle loss mitigation in asphalt by the addition of polyethylene foam (2024)
Journal Article
Abedraba-Abdalla, M., Thom, N., Garcia-Hernández, A., & Li, L. (2024). Particle loss mitigation in asphalt by the addition of polyethylene foam. Construction and Building Materials, 438, Article 137208. https://doi.org/10.1016/j.conbuildmat.2024.137208

This paper evaluates the feasibility of using a cellular foam as a substitute for capsules containing rejuvenators to mitigate the ravelling of Stone Mastic Asphalt and enhance its durability. While encapsulated rejuvenators have been shown to effect... Read More about Particle loss mitigation in asphalt by the addition of polyethylene foam.

The Acceptability of Intraoral Imaging in Children with Caries (2024)
Presentation / Conference Contribution
Allen, N., Farmer, N., Young, S., Dawett, B., Leighton, P., Blake, H., …Marshman, Z. (2024, July). The Acceptability of Intraoral Imaging in Children with Caries. Presented at 71st Congress ORCA 2024, Crete, Greece

Soft theorems for boostless amplitudes (2024)
Journal Article
Du, Z.-Z., & Stefanyszyn, D. (2024). Soft theorems for boostless amplitudes. Journal of High Energy Physics, 2024(7), Article 11. https://doi.org/10.1007/jhep07%282024%29011

We consider effective field theories (EFTs) of scalar fields with broken Lorentz boosts, which arise by taking the decoupling and flat-space limits of the EFT of inflation, and derive constraints that must be satisfied by the corresponding scattering... Read More about Soft theorems for boostless amplitudes.

Crossing the line? Exploring situated, interactional negotiations of parental involvement in primary homework in England and Italy (2024)
Journal Article
Lehner‐Mear, R., & Colla, V. (2024). Crossing the line? Exploring situated, interactional negotiations of parental involvement in primary homework in England and Italy. British Educational Research Journal, https://doi.org/10.1002/berj.4046

Primary school homework is a common practice internationally, historically viewed as an independent child activity, but more recently recognised as a family accomplishment. Parental involvement in homework has been principally discussed in relation t... Read More about Crossing the line? Exploring situated, interactional negotiations of parental involvement in primary homework in England and Italy.

Pharmacological Treatment of Musculoskeletal Pain (2024)
Other
Georgopoulos, V. (2024). Pharmacological Treatment of Musculoskeletal Pain. [Internet Resource]

Musculoskeletal pain management should accommodate patient choice, sensory and emotional aspects of pain, its diverse mechanisms in both peripheral and central nervous systems, and its context, including diagnosis, disability and co-morbidities, e... Read More about Pharmacological Treatment of Musculoskeletal Pain.

Reconstruction of the historic time course of blood‐borne virus contamination of clotting factor concentrates, 1974–1992 (2024)
Journal Article
McClure, C. P., Kean, K., Reid, K., Mayne, R., Fu, M. X., Rajendra, P., …Simmonds, P. (2024). Reconstruction of the historic time course of blood‐borne virus contamination of clotting factor concentrates, 1974–1992. Journal of Medical Virology, 96(7), Article e29774. https://doi.org/10.1002/jmv.29774

Factor VIII and IX clotting factor concentrates manufactured from pooled plasma have been identified as potent sources of virus infection in persons with hemophilia (PWHs) in the 1970s and 1980s. To investigate the range and diversity of viruses over... Read More about Reconstruction of the historic time course of blood‐borne virus contamination of clotting factor concentrates, 1974–1992.

Controlling Noncollinear Ferromagnetism in van der Waals Metal–Organic Magnets (2024)
Journal Article
Pitcairn, J., Ongkiko, M. A., Iliceto, A., Speakman, P. J., Calder, S., Cochran, M. J., Paddison, J. A. M., Liu, C., Argent, S. P., Morris, A. J., & Cliffe, M. J. (2024). Controlling Noncollinear Ferromagnetism in van der Waals Metal–Organic Magnets. Journal of the American Chemical Society, 146(28), 19146–19159. https://doi.org/10.1021/jacs.4c04102

Van der Waals (vdW) magnets both allow exploration of fundamental 2D physics and offer a route toward exploiting magnetism in next generation information technology, but vdW magnets with complex, noncollinear spin textures are currently rare. We repo... Read More about Controlling Noncollinear Ferromagnetism in van der Waals Metal–Organic Magnets.