All Outputs (1584)

Assessment of Acute Kidney Injury using MRI (2024)
Journal Article
Selby, N. M., & Francis, S. T. (2024). Assessment of Acute Kidney Injury using MRI. Journal of Magnetic Resonance Imaging, https://doi.org/10.1002/jmri.29281

There has been growing interest in using quantitative magnetic resonance imaging (MRI) to describe and understand the pathophysiology of acute kidney injury (AKI). The ability to assess kidney blood flow, perfusion, oxygenation, and changes in tissue... Read More about Assessment of Acute Kidney Injury using MRI.

Spatial functional mapping of hypoxia inducible factor heterodimerisation and immune checkpoint regulators in clear cell renal cell carcinoma (2024)
Journal Article
Safrygina, E., Applebee, C., McIntyre, A., Padget, J., & Larijani, B. (2024). Spatial functional mapping of hypoxia inducible factor heterodimerisation and immune checkpoint regulators in clear cell renal cell carcinoma. BJC Reports, 2, Article 10. https://doi.org/10.1038/s44276-023-00033-7

Background: Clear cell renal cell carcinoma (ccRCC) is a highly malignant subtype of kidney cancer. Ninety percent of ccRCC have inactivating mutations of VHL that stabilise transcription factors, HIF1α and HIF2α, only stabilised in hypoxia. The vari... Read More about Spatial functional mapping of hypoxia inducible factor heterodimerisation and immune checkpoint regulators in clear cell renal cell carcinoma.

How Institutional Logics Inform Emotional Labour: An Ethnography of Junior Doctors (2024)
Journal Article
Vedi, P., Korczynski, M., & Bishop, S. (in press). How Institutional Logics Inform Emotional Labour: An Ethnography of Junior Doctors. Work, Employment and Society, https://doi.org/10.1177/09500170231225615

Sociological analysis of emotional labour can be aided by considering how institutional logics inform the performance of emotional labour. We consider the link between institutional logics and emotional labour by conducting an in-depth case study of... Read More about How Institutional Logics Inform Emotional Labour: An Ethnography of Junior Doctors.

Determining the optimal treatment target in patients with ulcerative colitis: rationale, design, protocol and interim analysis for the randomised controlled VERDICT trial (2024)
Journal Article
Jairath, V., Zou, G., Wang, Z., Adsul, S., Colombel, J., D’Haens, G. R., …Feagan, B. G. (2024). Determining the optimal treatment target in patients with ulcerative colitis: rationale, design, protocol and interim analysis for the randomised controlled VERDICT trial. BMJ Open Gastroenterology, 11(1), Article e001218. https://doi.org/10.1136/bmjgast-2023-001218

Introduction: Symptoms, endoscopy and histology have been proposed as therapeutic targets in ulcerative colitis (UC). Observational studies suggest that the achievement of histologic remission may be associated with a lower risk of complications, com... Read More about Determining the optimal treatment target in patients with ulcerative colitis: rationale, design, protocol and interim analysis for the randomised controlled VERDICT trial.

Primary care consultation patterns prior to suicide: a nationally representative case-control study. (2024)
Journal Article
Alothman, D., Lewis, S., Fogarty, A. W., Card, T., & Tyrrell, E. (2024). Primary care consultation patterns prior to suicide: a nationally representative case-control study. British Journal of General Practice, 74(744), e426-e433. https://doi.org/10.3399/bjgp.2023.0509

Consultation with primary health care may provide an opportunity to identify patients at higher suicide risk. To explore primary care consultation patterns in the 5 years before suicide to identify suicide high-risk groups and common reasons for cons... Read More about Primary care consultation patterns prior to suicide: a nationally representative case-control study..

Motivation communication training programme for healthcare professionals to support adherence in patients with diabetic foot ulcers: Proof of concept study (2024)
Journal Article
Hancox, J. E., Chaplin, W. J., Hilton, C. E., Vadaszy, N., Gray, K., Game, F., & Vedhara, K. (2024). Motivation communication training programme for healthcare professionals to support adherence in patients with diabetic foot ulcers: Proof of concept study. PLoS ONE, 19(2), Article e0295180. https://doi.org/10.1371/journal.pone.0295180

Patients with diabetic foot ulcers have poor adherence to treatment recommendations. However, the most effective way to support adherence in this population is unknown. This study aimed to assess the preliminary effectiveness of a motivation communic... Read More about Motivation communication training programme for healthcare professionals to support adherence in patients with diabetic foot ulcers: Proof of concept study.

A framework for more equitable, diverse, and inclusive Patient and Public Involvement for palliative care research (2024)
Journal Article
Mitchell, S., Turner, N., Fryer, K., Beng, J., Ogden, M. E., Watson, M., …Evans, C. J. (2024). A framework for more equitable, diverse, and inclusive Patient and Public Involvement for palliative care research. Research Involvement and Engagement, 10(1), Article 19. https://doi.org/10.1186/s40900-023-00525-3

Background: There are marked inequalities in palliative care provision. Research is needed to understand how such inequalities can be addressed, so that everyone living with advanced illness can receive the care they need, when they need it. Research... Read More about A framework for more equitable, diverse, and inclusive Patient and Public Involvement for palliative care research.

Exploring genetic diversity and variation of Ovar-DRB1 gene in Sudan Desert Sheep using targeted next-generation sequencing (2024)
Journal Article
Salim, B., Nakao, R., Chatanga, E., Marcuzzi, O., Eissawi, M. A., Almathen, F., …Giovambattista, G. (2024). Exploring genetic diversity and variation of Ovar-DRB1 gene in Sudan Desert Sheep using targeted next-generation sequencing. BMC Genomics, 25(1), Article 160. https://doi.org/10.1186/s12864-024-10053-3

Introduction The Ovar-DRB1 gene, a crucial element of the Major Histocompatibility Complex (MHC) Class II region, initiates adaptive immunity by presenting antigens to T-cells. Genetic diversity in sheep, particularly in MHC Class II genes like Ovar... Read More about Exploring genetic diversity and variation of Ovar-DRB1 gene in Sudan Desert Sheep using targeted next-generation sequencing.

Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake (2024)
Journal Article
Ham, S., Mukaida, S., Sato, M., Keov, P., Bengtsson, T., Furness, S., …Hutchinson, D. S. (2024). Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake. Pharmacology Research and Perspectives, 12(1), Article e1176. https://doi.org/10.1002/prp2.1176

Truncation of the C‐terminal tail of the β2‐AR, transfection of βARKct or over‐expression of a kinase‐dead GRK mutant reduces isoprenaline‐stimulated glucose uptake, indicating that GRK is important for this response. We explored whether phosphorylat... Read More about Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake.

Coupled atomistic–continuum simulations of nucleate boiling (2024)
Journal Article
Gennari, G., Smith, E. R., Pringle, G. J., & Magnini, M. (2024). Coupled atomistic–continuum simulations of nucleate boiling. International Journal of Thermal Sciences, 200, Article 108954. https://doi.org/10.1016/j.ijthermalsci.2024.108954

Boiling is a striking example of a multiscale process, where the dynamics of bubbles is governed by the interplay between the molecular interactions responsible for nucleation, and the macroscale hydrodynamic and thermal boundary layers. A complete d... Read More about Coupled atomistic–continuum simulations of nucleate boiling.

Unveiling dark matter free streaming at the smallest scales with the high redshift Lyman-alpha forest (2024)
Journal Article
Iršič, V., Viel, M., Haehnelt, M. G., Bolton, J. S., Molaro, M., Puchwein, E., …Kulkarni, G. (2024). Unveiling dark matter free streaming at the smallest scales with the high redshift Lyman-alpha forest. Physical Review D, 109(4), Article 043511. https://doi.org/10.1103/physrevd.109.043511

This study introduces novel constraints on the free streaming of thermal relic warm dark matter (WDM) from Lyman-α forest flux power spectra. Our analysis utilizes a high resolution, high redshift sample of quasar spectra observed using the HIRES and... Read More about Unveiling dark matter free streaming at the smallest scales with the high redshift Lyman-alpha forest.

Fully angularly resolved 3D microrheology with optical tweezers (2024)
Journal Article
Matheson, A. B., Mendonca, T., Smith, M. G., Sutcliffe, B., Fernandez, A. J., Paterson, L., …Tassieri, M. (2024). Fully angularly resolved 3D microrheology with optical tweezers. Rheologica Acta, 63(3), 205-217. https://doi.org/10.1007/s00397-024-01435-1

Microrheology with optical tweezers (MOT) is an all-optical technique that allows the user to investigate a materials’ viscoelastic properties at microscopic scales, and is particularly useful for those materials that feature complex microstructures,... Read More about Fully angularly resolved 3D microrheology with optical tweezers.

University of Nottingham Rights Lab, response to the Climate Change Agreement: consultation on a new scheme (Department for Energy Security & Net Zero) (2024)
Report
Jackson, B. (2024). University of Nottingham Rights Lab, response to the Climate Change Agreement: consultation on a new scheme (Department for Energy Security & Net Zero). Department for Energy Security & Net Zero (DESNZ)

Short review and prospective: chalcogenide glass mid-infrared fibre lasers (2024)
Journal Article
Seddon, A. B., Farries, M., Nunes, J. J., Xiao, B., Furniss, D., Barney, E., …Sujecki, S. (2024). Short review and prospective: chalcogenide glass mid-infrared fibre lasers. European Physical Journal Plus, 139(2), Article 142. https://doi.org/10.1140/epjp/s13360-023-04841-1

Rare-earth ion doped, silica glass, optical fibre amplifiers have transformed the world by enabling high speed communications and the Internet. Fibre lasers, based on rare-earth ion doped silica glass optical fibres, achieve high optical powers and a... Read More about Short review and prospective: chalcogenide glass mid-infrared fibre lasers.

Probing the Mechanism of Action of Bis(phenolato) Amine (ONO Donor Set) Titanium(IV) Anticancer Agents (2024)
Journal Article
Musa, M., Abid, M., Bradshaw, T. D., Boocock, D. J., Coveney, C., Argent, S. P., & Woodward, S. (2024). Probing the Mechanism of Action of Bis(phenolato) Amine (ONO Donor Set) Titanium(IV) Anticancer Agents. Journal of Medicinal Chemistry, 67(4), 2732-2744. https://doi.org/10.1021/acs.jmedchem.3c01874

The need for anticancer therapies that overcome metallodrug resistance while minimizing adverse toxicities is targeted, herein, using titanium coordination complexes. Octahedral titanium­(IV) trans, mer-[Ti­{R1N­(CH2–2-MeO-4-R1-C6H2)2}2] [R1 = Et, al... Read More about Probing the Mechanism of Action of Bis(phenolato) Amine (ONO Donor Set) Titanium(IV) Anticancer Agents.

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches (2024)
Journal Article
Welsh, J. A., Goberdhan, D. C. I., O'Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., …Anderson, J. D. (2024). Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. Journal of Extracellular Vesicles, 13(2), Article e12404. https://doi.org/10.1002/jev2.12404

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated bro... Read More about Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches.

Online algorithms for ambulance routing in disaster response with time-varying victim conditions (2024)
Journal Article
Shiri, D., Akbari, V., & Salman, F. S. (2024). Online algorithms for ambulance routing in disaster response with time-varying victim conditions. OR Spectrum, https://doi.org/10.1007/s00291-024-00744-4

We present a novel online optimization approach to tackle the ambulance routing problem on a road network, specifically designed to handle uncertainties in travel times, triage levels, required treatment times of victims, and potential changes in vic... Read More about Online algorithms for ambulance routing in disaster response with time-varying victim conditions.

Urine Se concentration poorly predicts plasma Se concentration at sub-district scales in Zimbabwe, limiting its value as a biomarker of population Se status (2024)
Journal Article
Mutonhodza, B., Dembedza, M. P., Joy, E. J. M., Manzeke-Kangara, M. G., Njovo, H., Nyadzayo, T. K., …Chopera, P. (2024). Urine Se concentration poorly predicts plasma Se concentration at sub-district scales in Zimbabwe, limiting its value as a biomarker of population Se status. Frontiers in Nutrition, 11, Article 1288748. https://doi.org/10.3389/fnut.2024.1288748

Introduction: The current study investigated the value of urine selenium (Se) concentration as a biomarker of population Se status in rural sub-Saharan Africa. Method: Urine and plasma Se concentrations were measured among children aged 6–59 mont... Read More about Urine Se concentration poorly predicts plasma Se concentration at sub-district scales in Zimbabwe, limiting its value as a biomarker of population Se status.

Recording harms in randomized controlled trials of behavior change interventions: a scoping review and map of the evidence (2024)
Journal Article
Papaioannou, D., Hamer-Kiwacz, S., Mooney, C., Cooper, C., O'Cathain, A., Sprange, K., & Moody, G. (2024). Recording harms in randomized controlled trials of behavior change interventions: a scoping review and map of the evidence. Journal of Clinical Epidemiology, 169, Article 111275. https://doi.org/10.1016/j.jclinepi.2024.111275

Objectives: Randomized controlled trials evaluate diverse interventions. This can include medical interventions such as drugs or surgical procedures, or behavior change interventions (BCIs) that aim to change a habit, belief, or attitude to improve h... Read More about Recording harms in randomized controlled trials of behavior change interventions: a scoping review and map of the evidence.

Depression care integration in tuberculosis services: A feasibility assessment in Pakistan (2024)
Journal Article
Afaq, S., Ayub, A., Faisal, M. R., Nisar, Z., Rehman, A. U., Ahmed, A., …Siddiqi, N. (2024). Depression care integration in tuberculosis services: A feasibility assessment in Pakistan. Health Expectations, 27(1), Article e13985. https://doi.org/10.1111/hex.13985

Background: The co‐occurrence of depression among tuberculosis (TB) patients is a critical issue, contributing to poor treatment outcomes, prolonged hospitalisations and increased healthcare expenses. Objective: The objective of this study was to ass... Read More about Depression care integration in tuberculosis services: A feasibility assessment in Pakistan.