All Outputs (2492)

A framework for more equitable, diverse, and inclusive Patient and Public Involvement for palliative care research (2024)
Journal Article
Mitchell, S., Turner, N., Fryer, K., Beng, J., Ogden, M. E., Watson, M., Gardiner, C., Bayly, J., Sleeman, K. E., & Evans, C. J. (2024). A framework for more equitable, diverse, and inclusive Patient and Public Involvement for palliative care research. Research Involvement and Engagement, 10(1), Article 19. https://doi.org/10.1186/s40900-023-00525-3

Background: There are marked inequalities in palliative care provision. Research is needed to understand how such inequalities can be addressed, so that everyone living with advanced illness can receive the care they need, when they need it. Research... Read More about A framework for more equitable, diverse, and inclusive Patient and Public Involvement for palliative care research.

Exploring genetic diversity and variation of Ovar-DRB1 gene in Sudan Desert Sheep using targeted next-generation sequencing (2024)
Journal Article
Salim, B., Nakao, R., Chatanga, E., Marcuzzi, O., Eissawi, M. A., Almathen, F., …Giovambattista, G. (2024). Exploring genetic diversity and variation of Ovar-DRB1 gene in Sudan Desert Sheep using targeted next-generation sequencing. BMC Genomics, 25(1), Article 160. https://doi.org/10.1186/s12864-024-10053-3

Introduction
The Ovar-DRB1 gene, a crucial element of the Major Histocompatibility Complex (MHC) Class II region, initiates adaptive immunity by presenting antigens to T-cells. Genetic diversity in sheep, particularly in MHC Class II genes like Ovar... Read More about Exploring genetic diversity and variation of Ovar-DRB1 gene in Sudan Desert Sheep using targeted next-generation sequencing.

Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake (2024)
Journal Article
Ham, S., Mukaida, S., Sato, M., Keov, P., Bengtsson, T., Furness, S., Holliday, N. D., Evans, B. A., Summers, R. J., & Hutchinson, D. S. (2024). Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake. Pharmacology Research and Perspectives, 12(1), Article e1176. https://doi.org/10.1002/prp2.1176

Truncation of the C‐terminal tail of the β2‐AR, transfection of βARKct or over‐expression of a kinase‐dead GRK mutant reduces isoprenaline‐stimulated glucose uptake, indicating that GRK is important for this response. We explored whether phosphorylat... Read More about Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake.

Coupled atomistic–continuum simulations of nucleate boiling (2024)
Journal Article
Gennari, G., Smith, E. R., Pringle, G. J., & Magnini, M. (2024). Coupled atomistic–continuum simulations of nucleate boiling. International Journal of Thermal Sciences, 200, Article 108954. https://doi.org/10.1016/j.ijthermalsci.2024.108954

Boiling is a striking example of a multiscale process, where the dynamics of bubbles is governed by the interplay between the molecular interactions responsible for nucleation, and the macroscale hydrodynamic and thermal boundary layers. A complete d... Read More about Coupled atomistic–continuum simulations of nucleate boiling.

Unveiling dark matter free streaming at the smallest scales with the high redshift Lyman-alpha forest (2024)
Journal Article
Iršič, V., Viel, M., Haehnelt, M. G., Bolton, J. S., Molaro, M., Puchwein, E., …Kulkarni, G. (2024). Unveiling dark matter free streaming at the smallest scales with the high redshift Lyman-alpha forest. Physical Review D, 109(4), Article 043511. https://doi.org/10.1103/physrevd.109.043511

This study introduces novel constraints on the free streaming of thermal relic warm dark matter (WDM) from Lyman-α forest flux power spectra. Our analysis utilizes a high resolution, high redshift sample of quasar spectra observed using the HIRES and... Read More about Unveiling dark matter free streaming at the smallest scales with the high redshift Lyman-alpha forest.

Fully angularly resolved 3D microrheology with optical tweezers (2024)
Journal Article
Matheson, A. B., Mendonca, T., Smith, M. G., Sutcliffe, B., Fernandez, A. J., Paterson, L., …Tassieri, M. (2024). Fully angularly resolved 3D microrheology with optical tweezers. Rheologica Acta, 63(3), 205-217. https://doi.org/10.1007/s00397-024-01435-1

Microrheology with optical tweezers (MOT) is an all-optical technique that allows the user to investigate a materials’ viscoelastic properties at microscopic scales, and is particularly useful for those materials that feature complex microstructures,... Read More about Fully angularly resolved 3D microrheology with optical tweezers.

University of Nottingham Rights Lab, response to the Climate Change Agreement: consultation on a new scheme (Department for Energy Security & Net Zero) (2024)
Report
Jackson, B. (2024). University of Nottingham Rights Lab, response to the Climate Change Agreement: consultation on a new scheme (Department for Energy Security & Net Zero). Department for Energy Security & Net Zero (DESNZ)

Short review and prospective: chalcogenide glass mid-infrared fibre lasers (2024)
Journal Article
Seddon, A. B., Farries, M., Nunes, J. J., Xiao, B., Furniss, D., Barney, E., Phang, S., Chahal, S., Kalfagiannis, N., Sojka, Ł., & Sujecki, S. (2024). Short review and prospective: chalcogenide glass mid-infrared fibre lasers. European Physical Journal Plus, 139(2), Article 142. https://doi.org/10.1140/epjp/s13360-023-04841-1

Rare-earth ion doped, silica glass, optical fibre amplifiers have transformed the world by enabling high speed communications and the Internet. Fibre lasers, based on rare-earth ion doped silica glass optical fibres, achieve high optical powers and a... Read More about Short review and prospective: chalcogenide glass mid-infrared fibre lasers.

Probing the Mechanism of Action of Bis(phenolato) Amine (ONO Donor Set) Titanium(IV) Anticancer Agents (2024)
Journal Article
Musa, M., Abid, M., Bradshaw, T. D., Boocock, D. J., Coveney, C., Argent, S. P., & Woodward, S. (2024). Probing the Mechanism of Action of Bis(phenolato) Amine (ONO Donor Set) Titanium(IV) Anticancer Agents. Journal of Medicinal Chemistry, 67(4), 2732-2744. https://doi.org/10.1021/acs.jmedchem.3c01874

The need for anticancer therapies that overcome metallodrug resistance while minimizing adverse toxicities is targeted, herein, using titanium coordination complexes. Octahedral titanium­(IV) trans, mer-[Ti­{R1N­(CH2–2-MeO-4-R1-C6H2)2}2] [R1 = Et, al... Read More about Probing the Mechanism of Action of Bis(phenolato) Amine (ONO Donor Set) Titanium(IV) Anticancer Agents.

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches (2024)
Journal Article
Welsh, J. A., Goberdhan, D. C. I., O'Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., …Anderson, J. D. (2024). Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. Journal of Extracellular Vesicles, 13(2), Article e12404. https://doi.org/10.1002/jev2.12404

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated bro... Read More about Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches.

Online algorithms for ambulance routing in disaster response with time-varying victim conditions (2024)
Journal Article
Shiri, D., Akbari, V., & Salman, F. S. (2024). Online algorithms for ambulance routing in disaster response with time-varying victim conditions. OR Spectrum, 46(3), 785-819. https://doi.org/10.1007/s00291-024-00744-4

We present a novel online optimization approach to tackle the ambulance routing problem on a road network, specifically designed to handle uncertainties in travel times, triage levels, required treatment times of victims, and potential changes in vic... Read More about Online algorithms for ambulance routing in disaster response with time-varying victim conditions.

Urine Se concentration poorly predicts plasma Se concentration at sub-district scales in Zimbabwe, limiting its value as a biomarker of population Se status (2024)
Journal Article
Mutonhodza, B., Dembedza, M. P., Joy, E. J. M., Manzeke-Kangara, M. G., Njovo, H., Nyadzayo, T. K., …Chopera, P. (2024). Urine Se concentration poorly predicts plasma Se concentration at sub-district scales in Zimbabwe, limiting its value as a biomarker of population Se status. Frontiers in Nutrition, 11, Article 1288748. https://doi.org/10.3389/fnut.2024.1288748

Introduction: The current study investigated the value of urine selenium (Se) concentration as a biomarker of population Se status in rural sub-Saharan Africa.

Method: Urine and plasma Se concentrations were measured among children aged 6–59 mont... Read More about Urine Se concentration poorly predicts plasma Se concentration at sub-district scales in Zimbabwe, limiting its value as a biomarker of population Se status.

Recording harms in randomized controlled trials of behavior change interventions: a scoping review and map of the evidence (2024)
Journal Article
Papaioannou, D., Hamer-Kiwacz, S., Mooney, C., Cooper, C., O'Cathain, A., Sprange, K., & Moody, G. (2024). Recording harms in randomized controlled trials of behavior change interventions: a scoping review and map of the evidence. Journal of Clinical Epidemiology, 169, Article 111275. https://doi.org/10.1016/j.jclinepi.2024.111275

Objectives: Randomized controlled trials evaluate diverse interventions. This can include medical interventions such as drugs or surgical procedures, or behavior change interventions (BCIs) that aim to change a habit, belief, or attitude to improve h... Read More about Recording harms in randomized controlled trials of behavior change interventions: a scoping review and map of the evidence.

Depression care integration in tuberculosis services: A feasibility assessment in Pakistan (2024)
Journal Article
Afaq, S., Ayub, A., Faisal, M. R., Nisar, Z., Rehman, A. U., Ahmed, A., Zala, Todowede, O., & Siddiqi, N. (2024). Depression care integration in tuberculosis services: A feasibility assessment in Pakistan. Health Expectations, 27(1), Article e13985. https://doi.org/10.1111/hex.13985

Background: The co‐occurrence of depression among tuberculosis (TB) patients is a critical issue, contributing to poor treatment outcomes, prolonged hospitalisations and increased healthcare expenses. Objective: The objective of this study was to ass... Read More about Depression care integration in tuberculosis services: A feasibility assessment in Pakistan.

Linear and nonlinear optical investigations of polyvinyl chloride modified La2O3 nanocomposite films (2024)
Journal Article
Alhassan, S., Alshammari, K., Alshammari, M., Alotaibi, T., Alshammari, A. H., Alhamazani, A., …Abdel Mohaymen Taha, T. (2024). Linear and nonlinear optical investigations of polyvinyl chloride modified La2O3 nanocomposite films. Results in Physics, 58, Article 107456. https://doi.org/10.1016/j.rinp.2024.107456

In the present work, we report the effect and improvement of PVC polymer blend nanocomposites performance with addition of lanthanum oxide (La2O3) nanofiller. The structural properties of the samples were studied using different characterization tech... Read More about Linear and nonlinear optical investigations of polyvinyl chloride modified La2O3 nanocomposite films.

Development and Scale-Up of a New Sulfone-Based Bismacycle as a Universal Precursor for Bi(V)-Mediated Electrophilic Arylation (2024)
Journal Article
Fox, A., & Ball, L. T. (2024). Development and Scale-Up of a New Sulfone-Based Bismacycle as a Universal Precursor for Bi(V)-Mediated Electrophilic Arylation. Organic Process Research and Development, 28(2), 632-639. https://doi.org/10.1021/acs.oprd.3c00509

The scope and practical utility of bismuth(V)-mediated electrophilic arylation have been greatly improved by the recent development of user-friendly protocols based on modular bismacycle reagents. Here, we report the scalable synthesis of a new bench... Read More about Development and Scale-Up of a New Sulfone-Based Bismacycle as a Universal Precursor for Bi(V)-Mediated Electrophilic Arylation.

An empirical critique of the low income low energy efficiency approach to measuring fuel poverty (2024)
Journal Article
Semple, T., Rodrigues, L., Harvey, J., Figueredo, G., Nica-Avram, G., Gillott, M., …Goulding, J. (2024). An empirical critique of the low income low energy efficiency approach to measuring fuel poverty. Energy Policy, 186, Article 114014. https://doi.org/10.1016/j.enpol.2024.114014

Fuel poverty is a complex socioenvironmental issue of increasing global significance. In England, fuel poverty is assessed via the Low Income Low Energy Efficiency (LILEE) indicator, yet concerns exist regarding the efficacy of this metric given its... Read More about An empirical critique of the low income low energy efficiency approach to measuring fuel poverty.

Wetting of bio-rejuvenator nanodroplets on bitumen: A molecular dynamics investigation (2024)
Journal Article
Xu, H., Zou, Y., Airey, G., Wang, H., Zhang, H., Wu, S., & Chen, A. (2024). Wetting of bio-rejuvenator nanodroplets on bitumen: A molecular dynamics investigation. Journal of Cleaner Production, 444, Article 141140. https://doi.org/10.1016/j.jclepro.2024.141140

Wetting is the first step during the mix process between rejuvenator and bitumen, which is important for mix efficiency and performance recovery. The wetting of bio-rejuvenator nanodroplets on bitumen was investigated by molecular dynamics (MD) simul... Read More about Wetting of bio-rejuvenator nanodroplets on bitumen: A molecular dynamics investigation.

Safety and efficacy of autologous haematopoietic stem-cell transplantation with low-dose cyclophosphamide mobilisation and reduced intensity conditioning versus standard of care in refractory Crohn's disease (ASTIClite): an open-label, multicentre, randomised controlled trial (2024)
Journal Article
Lindsay, J. O., Hind, D., Swaby, L., Berntsson, H., Bradburn, M., Bannur C, U., …Snowden, J. A. (2024). Safety and efficacy of autologous haematopoietic stem-cell transplantation with low-dose cyclophosphamide mobilisation and reduced intensity conditioning versus standard of care in refractory Crohn's disease (ASTIClite): an open-label, multicentre, randomised controlled trial. The Lancet Gastroenterology & Hepatology, 9(4), 333-345. https://doi.org/10.1016/s2468-1253%2823%2900460-0

Background: A previous controlled trial of autologous haematopoietic stem-cell transplantation (HSCT) in patients with refractory Crohn's disease did not meet its primary endpoint and reported high toxicity. We aimed to assess the safety and efficacy... Read More about Safety and efficacy of autologous haematopoietic stem-cell transplantation with low-dose cyclophosphamide mobilisation and reduced intensity conditioning versus standard of care in refractory Crohn's disease (ASTIClite): an open-label, multicentre, randomised controlled trial.

Numerical modelling of tsunami propagation in idealised converging water body geometries (2024)
Journal Article
Chen, Z., Heller, V., & Briganti, R. (2024). Numerical modelling of tsunami propagation in idealised converging water body geometries. Coastal Engineering, 189, Article 104482. https://doi.org/10.1016/j.coastaleng.2024.104482

Tsunamis have caused many severe natural disasters in human history, such as in 2018 at Palu City located in a narrow bay resulting in over 4340 fatalities. The tsunami propagation characteristics are greatly affected by the water body geometry. For... Read More about Numerical modelling of tsunami propagation in idealised converging water body geometries.