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Bioengineered small extracellular vesicles deliver multiple SARS-CoV-2 antigenic fragments and drive a broad immunological response (2024)
Journal Article
Jackson, H. K., Long, H. M., Yam‐Puc, J. C., Palmulli, R., Haigh, T. A., Gerber, P. P., Lee, J. S., Matheson, N. J., Young, L., Trowsdale, J., Lo, M., Taylor, G. S., Thaventhiran, J. E., & Edgar, J. R. (2024). Bioengineered small extracellular vesicles deliver multiple SARS-CoV-2 antigenic fragments and drive a broad immunological response. Journal of Extracellular Vesicles, 13(2), Article e12412. https://doi.org/10.1002/jev2.12412

The COVID-19 pandemic highlighted the clear risk that zoonotic viruses pose to global health and economies. The scientific community responded by developing several efficacious vaccines which were expedited by the global need for vaccines. The emerge... Read More about Bioengineered small extracellular vesicles deliver multiple SARS-CoV-2 antigenic fragments and drive a broad immunological response.

The sphingosine 1‐phosphate analogue, FTY720, modulates the lipidomic signature of the mouse hippocampus (2024)
Journal Article
Magalhães, D. M., Stewart, N. A., Mampay, M., Rolle, S. O., Hall, C. M., Moeendarbary, E., …Sheridan, G. K. (in press). The sphingosine 1‐phosphate analogue, FTY720, modulates the lipidomic signature of the mouse hippocampus. Journal of Neurochemistry, https://doi.org/10.1111/jnc.16073

The small‐molecule drug, FTY720 (fingolimod), is a synthetic sphingosine 1‐phosphate (S1P) analogue currently used to treat relapsing–remitting multiple sclerosis in both adults and children. FTY720 can cross the blood–brain barrier (BBB) and, over t... Read More about The sphingosine 1‐phosphate analogue, FTY720, modulates the lipidomic signature of the mouse hippocampus.

Drought and heatwave affected the African eggplant differently when present in combination than individually (2024)
Journal Article
David-Rogeat, N., Broadley, M., & Stavridou, E. (2024). Drought and heatwave affected the African eggplant differently when present in combination than individually. Environmental and Experimental Botany, 220, Article 105670. https://doi.org/10.1016/j.envexpbot.2024.105670

Heat waves and drought periods are set to happen more often due to a changing climate, especially in Africa. The African eggplant, Solanum aethiopicum L., is a highly nutritious vegetable crop indigenous to Africa commonly grown by small-holder farme... Read More about Drought and heatwave affected the African eggplant differently when present in combination than individually.

Interfacial characteristics between bitumen and corrosion products on steel slag surface from molecular scale (2024)
Journal Article
Xu, H., Zou, Y., Airey, G., Wang, H., Zhang, H., Wu, S., Chen, A., Xie, J., & Liang, Y. (2024). Interfacial characteristics between bitumen and corrosion products on steel slag surface from molecular scale. Construction and Building Materials, 417, Article 135324. https://doi.org/10.1016/j.conbuildmat.2024.135324

Corrosion commonly happened on the surface of steel slag during the weathering and accumulation process, whose products would form weak points and affect the interface between bitumen and steel slag. To clear its characteristics in the atomic scales,... Read More about Interfacial characteristics between bitumen and corrosion products on steel slag surface from molecular scale.

The Parody Exception in EU Design Law: A Catalyst for Creative Evolution, Innovation and Cultural Discourse (2024)
Journal Article
Jacques, S., & Derclaye, E. (in press). The Parody Exception in EU Design Law: A Catalyst for Creative Evolution, Innovation and Cultural Discourse. European Intellectual Property Review,

This article delves into the recent proposals put forward by the European Commission, presented on the 28th of November 2022, which aim to revise key EU instruments governing the protection of design rights. With design legislation largely remaining... Read More about The Parody Exception in EU Design Law: A Catalyst for Creative Evolution, Innovation and Cultural Discourse.

On the splay deformation mode of a polar linearly elastic bar stretched by its own weight (2024)
Journal Article
Soldatos, K. P. (2024). On the splay deformation mode of a polar linearly elastic bar stretched by its own weight. Mechanics of Advanced Materials and Structures, https://doi.org/10.1080/15376494.2024.2313151

This communication considers the fundamental linear elasticity problem of a prismatic bar, or plate, stretched by its own weight and examines the impact of its classical solution in the regime of isotropic and anisotropic polar material elasticity. A... Read More about On the splay deformation mode of a polar linearly elastic bar stretched by its own weight.

Assessment of Acute Kidney Injury using MRI (2024)
Journal Article
Selby, N. M., & Francis, S. T. (2024). Assessment of Acute Kidney Injury using MRI. Journal of Magnetic Resonance Imaging, https://doi.org/10.1002/jmri.29281

There has been growing interest in using quantitative magnetic resonance imaging (MRI) to describe and understand the pathophysiology of acute kidney injury (AKI). The ability to assess kidney blood flow, perfusion, oxygenation, and changes in tissue... Read More about Assessment of Acute Kidney Injury using MRI.

Spatial functional mapping of hypoxia inducible factor heterodimerisation and immune checkpoint regulators in clear cell renal cell carcinoma (2024)
Journal Article
Safrygina, E., Applebee, C., McIntyre, A., Padget, J., & Larijani, B. (2024). Spatial functional mapping of hypoxia inducible factor heterodimerisation and immune checkpoint regulators in clear cell renal cell carcinoma. BJC Reports, 2, Article 10. https://doi.org/10.1038/s44276-023-00033-7

Background: Clear cell renal cell carcinoma (ccRCC) is a highly malignant subtype of kidney cancer. Ninety percent of ccRCC have inactivating mutations of VHL that stabilise transcription factors, HIF1α and HIF2α, only stabilised in hypoxia. The vari... Read More about Spatial functional mapping of hypoxia inducible factor heterodimerisation and immune checkpoint regulators in clear cell renal cell carcinoma.

How Institutional Logics Inform Emotional Labour: An Ethnography of Junior Doctors (2024)
Journal Article
Vedi, P., Korczynski, M., & Bishop, S. (in press). How Institutional Logics Inform Emotional Labour: An Ethnography of Junior Doctors. Work, Employment and Society, https://doi.org/10.1177/09500170231225615

Sociological analysis of emotional labour can be aided by considering how institutional logics inform the performance of emotional labour. We consider the link between institutional logics and emotional labour by conducting an in-depth case study of... Read More about How Institutional Logics Inform Emotional Labour: An Ethnography of Junior Doctors.

Determining the optimal treatment target in patients with ulcerative colitis: rationale, design, protocol and interim analysis for the randomised controlled VERDICT trial (2024)
Journal Article
Jairath, V., Zou, G., Wang, Z., Adsul, S., Colombel, J.-F., D’Haens, G. R., Freire, M., Moran, G. W., Peyrin-Biroulet, L., Sandborn, W. J., Sebastian, S., Travis, S., Vermeire, S., Radulescu, G., Sigler, J., Hanžel, J., Ma, C., Sedano, R., McFarlane, S. C., Arya, N., …Feagan, B. G. (2024). Determining the optimal treatment target in patients with ulcerative colitis: rationale, design, protocol and interim analysis for the randomised controlled VERDICT trial. BMJ Open Gastroenterology, 11(1), Article e001218. https://doi.org/10.1136/bmjgast-2023-001218

Introduction: Symptoms, endoscopy and histology have been proposed as therapeutic targets in ulcerative colitis (UC). Observational studies suggest that the achievement of histologic remission may be associated with a lower risk of complications, com... Read More about Determining the optimal treatment target in patients with ulcerative colitis: rationale, design, protocol and interim analysis for the randomised controlled VERDICT trial.

Primary care consultation patterns prior to suicide: a nationally representative case-control study. (2024)
Journal Article
Alothman, D., Lewis, S., Fogarty, A. W., Card, T., & Tyrrell, E. (2024). Primary care consultation patterns prior to suicide: a nationally representative case-control study. British Journal of General Practice, 74(744), e426-e433. https://doi.org/10.3399/bjgp.2023.0509

Consultation with primary health care may provide an opportunity to identify patients at higher suicide risk. To explore primary care consultation patterns in the 5 years before suicide to identify suicide high-risk groups and common reasons for cons... Read More about Primary care consultation patterns prior to suicide: a nationally representative case-control study..

Motivation communication training programme for healthcare professionals to support adherence in patients with diabetic foot ulcers: Proof of concept study (2024)
Journal Article
Hancox, J. E., Chaplin, W. J., Hilton, C. E., Vadaszy, N., Gray, K., Game, F., & Vedhara, K. (2024). Motivation communication training programme for healthcare professionals to support adherence in patients with diabetic foot ulcers: Proof of concept study. PLoS ONE, 19(2), Article e0295180. https://doi.org/10.1371/journal.pone.0295180

Patients with diabetic foot ulcers have poor adherence to treatment recommendations. However, the most effective way to support adherence in this population is unknown. This study aimed to assess the preliminary effectiveness of a motivation communic... Read More about Motivation communication training programme for healthcare professionals to support adherence in patients with diabetic foot ulcers: Proof of concept study.

A framework for more equitable, diverse, and inclusive Patient and Public Involvement for palliative care research (2024)
Journal Article
Mitchell, S., Turner, N., Fryer, K., Beng, J., Ogden, M. E., Watson, M., Gardiner, C., Bayly, J., Sleeman, K. E., & Evans, C. J. (2024). A framework for more equitable, diverse, and inclusive Patient and Public Involvement for palliative care research. Research Involvement and Engagement, 10(1), Article 19. https://doi.org/10.1186/s40900-023-00525-3

Background: There are marked inequalities in palliative care provision. Research is needed to understand how such inequalities can be addressed, so that everyone living with advanced illness can receive the care they need, when they need it. Research... Read More about A framework for more equitable, diverse, and inclusive Patient and Public Involvement for palliative care research.

Exploring genetic diversity and variation of Ovar-DRB1 gene in Sudan Desert Sheep using targeted next-generation sequencing (2024)
Journal Article
Salim, B., Nakao, R., Chatanga, E., Marcuzzi, O., Eissawi, M. A., Almathen, F., …Giovambattista, G. (2024). Exploring genetic diversity and variation of Ovar-DRB1 gene in Sudan Desert Sheep using targeted next-generation sequencing. BMC Genomics, 25(1), Article 160. https://doi.org/10.1186/s12864-024-10053-3

Introduction
The Ovar-DRB1 gene, a crucial element of the Major Histocompatibility Complex (MHC) Class II region, initiates adaptive immunity by presenting antigens to T-cells. Genetic diversity in sheep, particularly in MHC Class II genes like Ovar... Read More about Exploring genetic diversity and variation of Ovar-DRB1 gene in Sudan Desert Sheep using targeted next-generation sequencing.

Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake (2024)
Journal Article
Ham, S., Mukaida, S., Sato, M., Keov, P., Bengtsson, T., Furness, S., Holliday, N. D., Evans, B. A., Summers, R. J., & Hutchinson, D. S. (2024). Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake. Pharmacology Research and Perspectives, 12(1), Article e1176. https://doi.org/10.1002/prp2.1176

Truncation of the C‐terminal tail of the β2‐AR, transfection of βARKct or over‐expression of a kinase‐dead GRK mutant reduces isoprenaline‐stimulated glucose uptake, indicating that GRK is important for this response. We explored whether phosphorylat... Read More about Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake.

Coupled atomistic–continuum simulations of nucleate boiling (2024)
Journal Article
Gennari, G., Smith, E. R., Pringle, G. J., & Magnini, M. (2024). Coupled atomistic–continuum simulations of nucleate boiling. International Journal of Thermal Sciences, 200, Article 108954. https://doi.org/10.1016/j.ijthermalsci.2024.108954

Boiling is a striking example of a multiscale process, where the dynamics of bubbles is governed by the interplay between the molecular interactions responsible for nucleation, and the macroscale hydrodynamic and thermal boundary layers. A complete d... Read More about Coupled atomistic–continuum simulations of nucleate boiling.

Unveiling dark matter free streaming at the smallest scales with the high redshift Lyman-alpha forest (2024)
Journal Article
Iršič, V., Viel, M., Haehnelt, M. G., Bolton, J. S., Molaro, M., Puchwein, E., …Kulkarni, G. (2024). Unveiling dark matter free streaming at the smallest scales with the high redshift Lyman-alpha forest. Physical Review D, 109(4), Article 043511. https://doi.org/10.1103/physrevd.109.043511

This study introduces novel constraints on the free streaming of thermal relic warm dark matter (WDM) from Lyman-α forest flux power spectra. Our analysis utilizes a high resolution, high redshift sample of quasar spectra observed using the HIRES and... Read More about Unveiling dark matter free streaming at the smallest scales with the high redshift Lyman-alpha forest.

Fully angularly resolved 3D microrheology with optical tweezers (2024)
Journal Article
Matheson, A. B., Mendonca, T., Smith, M. G., Sutcliffe, B., Fernandez, A. J., Paterson, L., …Tassieri, M. (2024). Fully angularly resolved 3D microrheology with optical tweezers. Rheologica Acta, 63(3), 205-217. https://doi.org/10.1007/s00397-024-01435-1

Microrheology with optical tweezers (MOT) is an all-optical technique that allows the user to investigate a materials’ viscoelastic properties at microscopic scales, and is particularly useful for those materials that feature complex microstructures,... Read More about Fully angularly resolved 3D microrheology with optical tweezers.