Targeted DPPC/DMPG surface-modified voriconazole lipid nanoparticles control invasive pulmonary aspergillosis in immunocompromised population: in-vitro and in-vivo assessment

Fayyaz, Heba A.; EL-Massik, Magda A.; Bahey-El-Din, Mohammed; Abdel-Bary, Amany; Abdallah, Ossama Y.; Eltaher, Hoda M.

doi:10.1016/j.ijpharm.2023.123663

All Outputs (3438)

Real world evidence for public health decision-making on vaccination policies: perspectives from an expert roundtable (2023)
Journal Article
de Waure, C., Gärtner, B. C., Lopalco, P. L., Puig-Barbera, J., & Nguyen-Van-Tam, J. S. (2024). Real world evidence for public health decision-making on vaccination policies: perspectives from an expert roundtable. Expert Review of Vaccines, 23(1), 27-38. https://doi.org/10.1080/14760584.2023.2290194

INTRODUCTION: Influenza causes significant morbidity and mortality, but influenza vaccine uptake remains below most countries' targets. Vaccine policy recommendations vary, as do procedures for reviewing and appraising the evidence. AREAS COVERED: Du... Read More about Real world evidence for public health decision-making on vaccination policies: perspectives from an expert roundtable.

Methods for fungiform papillae assessment: A collaborative study among European research units (2023)
Journal Article
Piochi, M., Spinelli, S., Melis, M., Laureati, M., Feeney, E., Methven, L., …Dinnella, C. (2024). Methods for fungiform papillae assessment: A collaborative study among European research units. Food Quality and Preference, 113, Article 105076. https://doi.org/10.1016/j.foodqual.2023.105076

Fungiform papillae (FP) are the anatomical structures dedicated to gustatory and somatosensory signal triggering. Whether the density of FP (FPD = FP/cm2) is associated with oral responsiveness is controversial, and the disparity in previous findings... Read More about Methods for fungiform papillae assessment: A collaborative study among European research units.

Non-reacting Numerical Simulation of Axisymmetric Trapped Vortex Combustor (2023)
Presentation / Conference Contribution
DAKKA, S., Singh, K., Jefferson-Loveday, R., & Serhat, H. (2023). Non-reacting Numerical Simulation of Axisymmetric Trapped Vortex Combustor.

This paper will focus on suitability of trapped vortex combustor as a candidate for gas turbine combustor objective to minimize pressure drop across combustor and investigating aerodynamic performance. Non-reacting simulation of axisymmetric cavity t... Read More about Non-reacting Numerical Simulation of Axisymmetric Trapped Vortex Combustor.

Dynamic updating of clinical survival prediction models in a changing environment (2023)
Journal Article
Tanner, K. T., Keogh, R. H., Coupland, C. A. C., Hippisley-Cox, J., & Diaz-Ordaz, K. (2023). Dynamic updating of clinical survival prediction models in a changing environment. Diagnostic and Prognostic Research, 7, Article 24. https://doi.org/10.1186/s41512-023-00163-z

Background
Over time, the performance of clinical prediction models may deteriorate due to changes in clinical management, data quality, disease risk and/or patient mix. Such prediction models must be updated in order to remain useful. In this study... Read More about Dynamic updating of clinical survival prediction models in a changing environment.

Solutions for recycling emerging wind turbine blade waste in China are not yet effective (2023)
Journal Article
Yang, J., Meng, F., Zhang, L., McKechnie, J., Chang, Y., Ma, B., …Cullen, J. M. (2023). Solutions for recycling emerging wind turbine blade waste in China are not yet effective. Communications Earth & Environment, 4(1), Article 466. https://doi.org/10.1038/s43247-023-01104-w

Wind power supply chains are evolving as markets expand to reach climate goals. With the largest installed wind power capacity globally, China must deal with increasing composite turbine waste and anticipate its associated costs. Here we predict the... Read More about Solutions for recycling emerging wind turbine blade waste in China are not yet effective.

A velocity-based moving mesh virtual element method (2023)
Journal Article
Wells, H., Hubbard, M., & Cangiani, A. (2024). A velocity-based moving mesh virtual element method. Computers and Mathematics with Applications, 155, 110-125. https://doi.org/10.1016/j.camwa.2023.12.005

We present a velocity-based moving mesh virtual element method for the numerical solution of PDEs involving boundaries which are free to move. The virtual element method is used for computing both the mesh velocity and a conservative Arbitrary Lagran... Read More about A velocity-based moving mesh virtual element method.

10. In Search of Lost Time: An Ensemble of Policies to Restore Fiscal Progressivity and Address the Climate Challenge (2023)
Book Chapter
Guzzardi, D., Palagi, E., Faccio, T., & Roventini, A. (2023). 10. In Search of Lost Time: An Ensemble of Policies to Restore Fiscal Progressivity and Address the Climate Challenge. In F. Cerniglia, F. Saraceno, & A. Watt (Eds.), Financing Investment in Times of High Public Debt: 2023 European Public Investment Outlook (169-190). Open Book Publishers. https://doi.org/10.11647/obp.0386.10

The European Union needs to raise significant resources to finance a just green transition. At the same time, there is a widespread fiscal regressivity in many EU countries. Indeed, recent empirical evidence shows that the tax systems of many EU memb... Read More about 10. In Search of Lost Time: An Ensemble of Policies to Restore Fiscal Progressivity and Address the Climate Challenge.

Model-based evaluation of admission screening strategies for the detection and control of carbapenemase-producing Enterobacterales in the English hospital setting (2023)
Journal Article
Pople, D., Kypraios, T., Donker, T., Stoesser, N., Seale, A. C., George, R., …Robotham, J. (2023). Model-based evaluation of admission screening strategies for the detection and control of carbapenemase-producing Enterobacterales in the English hospital setting. BMC Medicine, 21(1), Article 492. https://doi.org/10.1186/s12916-023-03007-1

Background
Globally, detections of carbapenemase-producing Enterobacterales (CPE) colonisations and infections are increasing. The spread of these highly resistant bacteria poses a serious threat to public health. However, understanding of CPE trans... Read More about Model-based evaluation of admission screening strategies for the detection and control of carbapenemase-producing Enterobacterales in the English hospital setting.

Association between quadriceps tendon elasticity and neuromuscular control in individuals with knee osteoarthritis. (2023)
Journal Article
Dickson, D. M., Smith, S. L., & Hendry, G. J. (2024). Association between quadriceps tendon elasticity and neuromuscular control in individuals with knee osteoarthritis. Clinical Biomechanics, 111, Article 106159. https://doi.org/10.1016/j.clinbiomech.2023.106159

Background: Knee osteoarthritis is a complex condition with established risk factors such as female sex, increasing age and body mass index, reduced quadriceps muscle strength and knee injury. Despite known associated risks, the role and behaviour of... Read More about Association between quadriceps tendon elasticity and neuromuscular control in individuals with knee osteoarthritis..

Is the Party Really Over? Parties, Partisanship and the Politics of Crime (2023)
Journal Article
Guiney, T. (2024). Is the Party Really Over? Parties, Partisanship and the Politics of Crime. British Journal of Criminology, 64(4), 947-963. https://doi.org/10.1093/bjc/azad075

Political parties occupy a contradictory position in the criminological literature: at once active participants in the political contestation of crime but virtually absent from contemporary debates concerning the relationship between crime and democr... Read More about Is the Party Really Over? Parties, Partisanship and the Politics of Crime.

Two-week break in methotrexate treatment and COVID-19 vaccine response: a prospective, open label, two-arm parallel-group, multicentre, superiority, randomised controlled trial (2023)
Journal Article
Abhishek, A., Peckham, N., Pade, C., Gibbons, J. M., Cureton, L., Francis, A., …Study investigators, V. (2024). Two-week break in methotrexate treatment and COVID-19 vaccine response: a prospective, open label, two-arm parallel-group, multicentre, superiority, randomised controlled trial. The Lancet Rheumatology, 6(2), E92-E104. https://doi.org/10.1016/S2665-9913%2823%2900298-9

Background
Methotrexate is the first-line treatment for immune-mediated inflammatory diseases and reduces vaccine-induced immunity. We evaluated if a 2-week interruption of methotrexate treatment immediately after COVID-19 booster vaccination improv... Read More about Two-week break in methotrexate treatment and COVID-19 vaccine response: a prospective, open label, two-arm parallel-group, multicentre, superiority, randomised controlled trial.

mm-Wave Low Insertion Loss SIW Phase Shifter Based on Liquid Metal Technology (2023)
Journal Article
Alkaraki, S., Qu, Z., & Kelly, J. R. (2024). mm-Wave Low Insertion Loss SIW Phase Shifter Based on Liquid Metal Technology. IEEE Microwave and Wireless Technology Letters, 34(2), 155-158. https://doi.org/10.1109/LMWT.2023.3339200

This letter presents the proof of concept of first liquid metal (LM)-based millimeter-wave (mm-wave) phase shifter that have very low insertion loss (IL) performance. The proposed phase shifter has a phase shift up to 360° with a phase resolution of... Read More about mm-Wave Low Insertion Loss SIW Phase Shifter Based on Liquid Metal Technology.

Age and sex differences in LDL cholesterol distribution in adults in Malaysia: A cross-sectional study (2010 -2021) (2023)
Journal Article
Chalitsios, C. V., Akyea, R. K., Abdul-Hamid, H., Leonardi-Bee, J., Kanchau, J. D., Kamal, A., …Qureshi, N. (2023). Age and sex differences in LDL cholesterol distribution in adults in Malaysia: A cross-sectional study (2010 -2021). International Journal of General Medicine, 2023(16), 5885—5888. https://doi.org/10.2147/IJGM.S423091

Cardiovascular disease (CVD) is the leading cause of death worldwide. Hypercholesterolaemia, especially higher low-density lipoprotein cholesterol (LDL-c), has been recognised as one of the major key risk factors for CVD. Lipid lowering treatments, s... Read More about Age and sex differences in LDL cholesterol distribution in adults in Malaysia: A cross-sectional study (2010 -2021).

Kinetics and toxicological potential of heavy metal leaching from asphalt pavements (2023)
Journal Article
Zou, F., Leng, Z., Tan, Z., Li, D., Han, M., Lu, G., & Sreeram, A. (2024). Kinetics and toxicological potential of heavy metal leaching from asphalt pavements. Science of the Total Environment, 912, Article 169193. https://doi.org/10.1016/j.scitotenv.2023.169193

The leaching of heavy metals from asphalt pavement has attracted increasing attention due to its associated environmental risks. Comprehending the leaching process is crucial for ensuring the safe utilization of asphalt pavement. This study investiga... Read More about Kinetics and toxicological potential of heavy metal leaching from asphalt pavements.

Quantitative expression of oestrogen receptor in breast cancer: Clinical and molecular significance (2023)
Journal Article
Makhlouf, S., Quinn, C., Toss, M., Alsaleem, M., Atallah, N. M., Ibrahim, A., …Rakha, E. A. (2024). Quantitative expression of oestrogen receptor in breast cancer: Clinical and molecular significance. European Journal of Cancer, 197, Article 113473. https://doi.org/10.1016/j.ejca.2023.113473

Background

Oestrogen receptor (ER) positive breast cancer (BC) patients are eligible for endocrine therapy (ET), regardless of ER immunohistochemical expression level. There is a wide spectrum of ER expression and the response to ET is not uniform... Read More about Quantitative expression of oestrogen receptor in breast cancer: Clinical and molecular significance.

Regional variations and deprivation are linked to poorer access to laparoscopic and robotic colorectal surgery: a national study in England (2023)
Journal Article
Morton, A. J., Simpson, A., & Humes, D. J. (2024). Regional variations and deprivation are linked to poorer access to laparoscopic and robotic colorectal surgery: a national study in England. Techniques in Coloproctology, 28(1), Article 9. https://doi.org/10.1007/s10151-023-02874-3

Background: Laparoscopic and now robotic colorectal surgery has rapidly increased in prevalence; however, little is known about how uptake varies by region and sociodemographics. The aim of this study was to quantify the uptake of minimally invasive... Read More about Regional variations and deprivation are linked to poorer access to laparoscopic and robotic colorectal surgery: a national study in England.

BubbleDet: a Python package to compute functional determinants for bubble nucleation (2023)
Journal Article
Ekstedt, A., Gould, O., & Hirvonen, J. (2023). BubbleDet: a Python package to compute functional determinants for bubble nucleation. Journal of High Energy Physics, 2023(12), Article 56. https://doi.org/10.1007/jhep12%282023%29056

We present a Python package BubbleDet for computing one-loop functional determinants around spherically symmetric background fields. This gives the next-to-leading order correction to both the vacuum decay rate, at zero temperature, and to the bubble... Read More about BubbleDet: a Python package to compute functional determinants for bubble nucleation.

Cost-effectiveness of Spironolactone for Adult Female Acne (SAFA): economic evaluation alongside a randomised controlled trial (2023)
Journal Article
Pyne, S., Sach, T. H., Lawrence, M., Renz, S., Eminton, Z., Stuart, B., …Santer, M. (2023). Cost-effectiveness of Spironolactone for Adult Female Acne (SAFA): economic evaluation alongside a randomised controlled trial. BMJ Open, 13(12), Article e073245. https://doi.org/10.1136/bmjopen-2023-073245

Objective This study aims to estimate the cost-effectiveness of oral spironolactone plus routine topical treatment compared with routine topical treatment alone for persistent acne in adult women from a British NHS perspective over 24 weeks. Design E... Read More about Cost-effectiveness of Spironolactone for Adult Female Acne (SAFA): economic evaluation alongside a randomised controlled trial.

Ensemble strategy using particle swarm optimisation variant and enhanced local search capability (2023)
Journal Article
Hong, L., Wang, G., Özcan, E., & Woodward, J. (2023). Ensemble strategy using particle swarm optimisation variant and enhanced local search capability. Swarm and Evolutionary Computation, 84, Article 101452. https://doi.org/10.1016/j.swevo.2023.101452

Particle swarm optimisation is a population-based algorithm for evolutionary computation. A notable recent research direction has been to combine different effective mechanisms to enhance both exploration and exploitation capabilities while employing... Read More about Ensemble strategy using particle swarm optimisation variant and enhanced local search capability.

Targeted DPPC/DMPG surface-modified voriconazole lipid nanoparticles control invasive pulmonary aspergillosis in immunocompromised population: in-vitro and in-vivo assessment (2023)
Journal Article
Fayyaz, H. A., EL-Massik, M. A., Bahey-El-Din, M., Abdel-Bary, A., Abdallah, O. Y., & Eltaher, H. M. (2024). Targeted DPPC/DMPG surface-modified voriconazole lipid nanoparticles control invasive pulmonary aspergillosis in immunocompromised population: in-vitro and in-vivo assessment. International Journal of Pharmaceutics, 649, Article 123663. https://doi.org/10.1016/j.ijpharm.2023.123663

Invasive pulmonary aspergillosis (IPA) is the most devastating Aspergillus-related lung disease. Voriconazole (VRZ) is the first-line treatment against IPA. Despite availability in oral and parenteral dosage forms, risks of systemic toxicity dictate... Read More about Targeted DPPC/DMPG surface-modified voriconazole lipid nanoparticles control invasive pulmonary aspergillosis in immunocompromised population: in-vitro and in-vivo assessment.