NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma
(2023)
Journal Article
Kubala, J. M., Laursen, K. B., Schreiner, R., Williams, R. M., van der Mijn, J. C., Crowley, M. J., …Gudas, L. J. (2023). NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma. Cancer Biology and Therapy, 24(1), Article 2170669. https://doi.org/10.1080/15384047.2023.2170669
In clear cell renal cell carcinoma (ccRCC), activation of hypoxic signaling induces NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2) expression. Over 90% of ccRCCs exhibit overexpression of NDUFA4L2, which we previously showed... Read More about NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma.