A Novel Bacteriophage with Broad Host Range against Clostridioides difficile Ribotype 078 Supports SlpA as the Likely Phage Receptor

Whittle, M. J.; Bilverstone, T. W.; Van Esveld, R. J.; Lücke, A. C.; Lister, M. M.; Kuehne, S. A.; Minton, N. P.

doi:10.1128/spectrum.02295-21

All Outputs (3422)

Investigating the Impact of AI-powered Technologies on Instagrammers' Purchase Decisions in Digitalization Era: A Study of the Fashion and Apparel Industry (2022)
Journal Article
Yeo, S. F., Tan, C. L., Kumar, A., Tan, K. H., & Wong, J. K. (2022). Investigating the Impact of AI-powered Technologies on Instagrammers' Purchase Decisions in Digitalization Era: A Study of the Fashion and Apparel Industry. Technological Forecasting and Social Change, 177, Article 121551. https://doi.org/10.1016/j.techfore.2022.121551

Over the last couple of decades, technological advancements have accelerated exponentially, especially in the realm of online social networking networks. The artificial intelligence (AI)-powered digital technologies applications continue to emerge to... Read More about Investigating the Impact of AI-powered Technologies on Instagrammers' Purchase Decisions in Digitalization Era: A Study of the Fashion and Apparel Industry.

Behaviours of Patients Who Take Their Strong Opioids as Unmeasured ‘Sips’ (2022)
Journal Article
Perkins, P., Parkinson, A., Hebdon, R., & Akyea, R. K. (2022). Behaviours of Patients Who Take Their Strong Opioids as Unmeasured ‘Sips’. Journal of Pain and Symptom Management, 63(6), e691-697. https://doi.org/10.1016/j.jpainsymman.2022.01.018

Context: Some patients take their strong opioid painkillers as unmeasured sips. Objectives: To investigate how and why patients take their medication in this way. Methods: Patient receiving specialist palliative care who take their strong opioid pain... Read More about Behaviours of Patients Who Take Their Strong Opioids as Unmeasured ‘Sips’.

Porphyromonas pasteri and Prevotella nanceiensis in the sputum microbiota are associated with increased decline in lung function in individuals with cystic fibrosis (2022)
Journal Article
Webb, K., Zain, N. M. M., Stewart, I., Fogarty, A., Nash, E. F., Whitehouse, J. L., …Barr, H. L. (2022). Porphyromonas pasteri and Prevotella nanceiensis in the sputum microbiota are associated with increased decline in lung function in individuals with cystic fibrosis. Journal of Medical Microbiology, 71(2), Article 001481. https://doi.org/10.1099/jmm.0.001481

Although anaerobic bacteria exist in abundance in cystic fibrosis (CF) airways, their role in disease progression is poorly understood. We hypothesized that the presence and relative abundance of the most prevalent, live, anaerobic bacteria in sputum... Read More about Porphyromonas pasteri and Prevotella nanceiensis in the sputum microbiota are associated with increased decline in lung function in individuals with cystic fibrosis.

Layered tungsten-based composites and their pseudocapacitive and electrocatalytic performance (2022)
Journal Article
Ola, O., Thummavichai, K., Chen, Y., Wang, N., Niu, Q., Wang, J., …Zhu, Y. (2022). Layered tungsten-based composites and their pseudocapacitive and electrocatalytic performance. Materials Chemistry Frontiers, 6(6), 737-747. https://doi.org/10.1039/D1QM00678A

With the rapid development of heterostructured electrocatalysts, the potential application of transition metal dichalcogenide (TMD)-based composites for electrocatalysis have attracted intense attraction owing to their unique optical, electronic, and... Read More about Layered tungsten-based composites and their pseudocapacitive and electrocatalytic performance.

A population framework for predicting the proportion of people infected by the far-field airborne transmission of SARS-CoV-2 indoors (2022)
Preprint / Working Paper
Iddon, C., Jones, B., Sharpe, P., Cevik, M., & Fitzgerald, S. A population framework for predicting the proportion of people infected by the far-field airborne transmission of SARS-CoV-2 indoors

The number of occupants in a space influences the risk of far-field airborne transmission of SARS-CoV-2 because the likelihood of having infectious and susceptible people both correlate with the number of occupants. This paper explores the relationsh... Read More about A population framework for predicting the proportion of people infected by the far-field airborne transmission of SARS-CoV-2 indoors.

A wave finite element approach for modelling wave transmission through laminated plate junctions (2022)
Journal Article
Aimakov, N., Tanner, G., & Chronopoulos, D. (2022). A wave finite element approach for modelling wave transmission through laminated plate junctions. Scientific Reports, 12(1), Article 1852. https://doi.org/10.1038/s41598-022-05685-y

We present a numerical method for computing reflection and transmission coefficients at joints connecting composite laminated plates. The method is based on modelling joints with finite elements with boundary conditions given by the solutions of the... Read More about A wave finite element approach for modelling wave transmission through laminated plate junctions.

Overview of Noninterpretive Artificial Intelligence Models for Safety, Quality, Workflow, and Education Applications in Radiology Practice (2022)
Journal Article
Tadavarthi, Y., Makeeva, V., Wagstaff, W., Zhan, H., Podlasek, A., Bhatia, N., …Trivedi, H. (2022). Overview of Noninterpretive Artificial Intelligence Models for Safety, Quality, Workflow, and Education Applications in Radiology Practice. Radiology: Artificial Intelligence, 4(2), Article e210114. https://doi.org/10.1148/ryai.210114

Artificial intelligence has become a ubiquitous term in radiology over the past several years, and much attention has been given to applications that aid radiologists in the detection of abnormalities and diagnosis of diseases. However, there are man... Read More about Overview of Noninterpretive Artificial Intelligence Models for Safety, Quality, Workflow, and Education Applications in Radiology Practice.

Clustering of comorbidities and associated outcomes in people with osteoarthritis - A UK Clinical Practice Research Datalink study (2022)
Journal Article
Swain, S., Coupland, C., Strauss, V., Mallen, C., Kuo, C. F., Sarmanova, A., …Zhang, W. (2022). Clustering of comorbidities and associated outcomes in people with osteoarthritis - A UK Clinical Practice Research Datalink study. Osteoarthritis and Cartilage, 30(5), 702-713. https://doi.org/10.1016/j.joca.2021.12.013

Objective: To examine the clusters of chronic conditions present in people with osteoarthritis and the associated risk factors and health outcomes. Methods: Clinical Practice Research Datalink (CPRD) GOLD was used to identify people diagnosed with in... Read More about Clustering of comorbidities and associated outcomes in people with osteoarthritis - A UK Clinical Practice Research Datalink study.

Imitation learning for coordinated human–robot collaboration based on hidden state-space models (2022)
Journal Article
Wang, L., Wang, G., Jia, S., Turner, A., & Ratchev, S. (2022). Imitation learning for coordinated human–robot collaboration based on hidden state-space models. Robotics and Computer-Integrated Manufacturing, 76, Article 102310. https://doi.org/10.1016/j.rcim.2021.102310

This paper proposes a novel coordinated human–robot collaboration framework based on the hidden state-space model, which probabilistically clones the human behaviour and presents dynamic features in a nonparametric form. Derived from the filter predi... Read More about Imitation learning for coordinated human–robot collaboration based on hidden state-space models.

Systematic review of pharmacological interventions for people with Lewy body dementia (2022)
Journal Article
Watts, K. E., Storr, N. J., Barr, P. G., & Rajkumar, A. P. (2022). Systematic review of pharmacological interventions for people with Lewy body dementia. Aging and Mental Health, 27(2), 203-216. https://doi.org/10.1080/13607863.2022.2032601

Objective: Lewy body dementia (LBD) is the second most common neurodegenerative dementia, and it causes earlier mortality and more morbidity than Alzheimer’s disease. Reviewing current evidence on its pharmacological management is essential for devel... Read More about Systematic review of pharmacological interventions for people with Lewy body dementia.

Torque Limiters for Aerospace Actuator Application (2022)
Journal Article
Shahjahan Ahmad, S., Tom, L., La Rocca, A., La Rocca, S., Vakil, G., Gerada, C., & Benarous, M. (2022). Torque Limiters for Aerospace Actuator Application. Energies, 15(4), Article 1467. https://doi.org/10.3390/en15041467

Safety and reliability of electrical actuators are essential for success of all electric and more electric aircrafts (MEA). Torque limiters improve the reliability of electromechanical actuators (EMA) by restricting the amount of force experienced by... Read More about Torque Limiters for Aerospace Actuator Application.

Human, Organisational and Societal Factors in Robotic Rail Infrastructure Maintenance (2022)
Journal Article
Golightly, D., Chan-Pensley, J., Dadashi, N., Jundi, S., Ryan, B., & Hall, A. (2022). Human, Organisational and Societal Factors in Robotic Rail Infrastructure Maintenance. Sustainability, 14(4), 1-28. https://doi.org/10.3390/su14042123

Robotics are set to play a significant role in the maintenance of rail infrastructure. However, the introduction of robotics in this environment requires new ways of working for individuals, teams and organisations and needs to reflect societal attit... Read More about Human, Organisational and Societal Factors in Robotic Rail Infrastructure Maintenance.

Correction to “Bespoke 3D-Printed Polydrug Implants Created via Microstructural Control of Oligomers” (2022)
Journal Article
Ruiz-Cantu, L., Trindade, G. F., Taresco, V., Zhou, Z., He, Y., Burroughs, L., …Wildman, R. D. (2022). Correction to “Bespoke 3D-Printed Polydrug Implants Created via Microstructural Control of Oligomers”. ACS Applied Materials and Interfaces, 14(6), 8654. https://doi.org/10.1021/acsami.2c00035

The chemical structure of the drug trandolapril has been corrected in Figure 4c. The conclusions of the work have not been affected by this correction. (Figure present).

A Simple Whole-Plasmid PCR Method to Construct High-Diversity Synthetic Phage Display Libraries (2022)
Journal Article
Tsoumpeli, M. T., Gray, A., Parsons, A. L., Spiliotopoulos, A., Owen, J. P., Bishop, K., …Gough, K. C. (2022). A Simple Whole-Plasmid PCR Method to Construct High-Diversity Synthetic Phage Display Libraries. Molecular Biotechnology, 64, 791-803. https://doi.org/10.1007/s12033-021-00442-4

Phage display technology utilises peptide and antibody libraries with very high diversities to select ligands with specific binding properties. The production of such libraries can be labour intensive and technically challenging and whilst there are... Read More about A Simple Whole-Plasmid PCR Method to Construct High-Diversity Synthetic Phage Display Libraries.

The effect of environmental temperature on average daily gain in preweaned calves: A randomized controlled trial and Bayesian analysis (2022)
Journal Article
Hyde, R. M., Green, M. J., Hudson, C., & Down, P. M. (2022). The effect of environmental temperature on average daily gain in preweaned calves: A randomized controlled trial and Bayesian analysis. Journal of Dairy Science, 105(4), 3430-3439. https://doi.org/10.3168/jds.2021-21199

Neonatal calves are relatively susceptible to heat loss, and previous research suggests that reduced environmental temperatures are associated with reduced average daily gain (ADG) during the preweaning phase. Current methods of mitigating negative e... Read More about The effect of environmental temperature on average daily gain in preweaned calves: A randomized controlled trial and Bayesian analysis.

Characterisation of fatigue damage in asphalt mixtures using X-ray computed tomography (2022)
Journal Article
Chen, A., Airey, G., Thom, N., & Li, Y. (2022). Characterisation of fatigue damage in asphalt mixtures using X-ray computed tomography. Road Materials and Pavement Design, https://doi.org/10.1080/14680629.2022.2029756

The high-resolution X-ray CT was applied to investigate the fatigue damage evolution of asphalt mixtures. The detailed Xray CT images in the centre of the samples were used to characterise the fatigue cracking and air voids increase at different vert... Read More about Characterisation of fatigue damage in asphalt mixtures using X-ray computed tomography.

Spatial Growth Rate of Emerging SARS-CoV-2 Lineages in England, September 2020–December 2021 (2022)
Preprint / Working Paper
The COVID-19 Genomics UK (COG-UK) Consortium, Smallman-Raynor, M., & Cliff, A. D. Spatial Growth Rate of Emerging SARS-CoV-2 Lineages in England, September 2020–December 2021

This paper uses a robust method of spatial epidemiological analysis to assess the spatial growth rate of multiple lineages of SARS-CoV-2 in the local authority areas of England, September 2020-December 2021. Using the genomic surveillance records of... Read More about Spatial Growth Rate of Emerging SARS-CoV-2 Lineages in England, September 2020–December 2021.

Quadratic curvature corrections to stringy effective actions and the absence of de Sitter vacua (2022)
Journal Article
Cunillera, F., Emond, W. T., Lehébel, A., & Padilla, A. (2022). Quadratic curvature corrections to stringy effective actions and the absence of de Sitter vacua. Journal of High Energy Physics, 2022(2), Article 12. https://doi.org/10.1007/jhep02%282022%29012

We investigate the combined effect of fluxes and higher-order curvature corrections, in the form of the Gauss-Bonnet term, on the existence of de Sitter vacua in a heterotic string inspired framework, compactified on spheres and tori. We first gain s... Read More about Quadratic curvature corrections to stringy effective actions and the absence of de Sitter vacua.

Current status and future development of hybrid PV/T system with PCM module: 4E (energy, exergy, economic and environmental) assessments (2022)
Journal Article
Cui, Y., Zhu, J., Zhang, F., Shao, Y., & Xue, Y. (2022). Current status and future development of hybrid PV/T system with PCM module: 4E (energy, exergy, economic and environmental) assessments. Renewable and Sustainable Energy Reviews, 158, Article 112147. https://doi.org/10.1016/j.rser.2022.112147

Solar photovoltaic thermal (PV/T) with phase change material (PCM) technology is one of the incentive research areas in renewable energy application aspect, which attracts increasingly attention in the globalized market to tackle climate change. The... Read More about Current status and future development of hybrid PV/T system with PCM module: 4E (energy, exergy, economic and environmental) assessments.

A Novel Bacteriophage with Broad Host Range against Clostridioides difficile Ribotype 078 Supports SlpA as the Likely Phage Receptor (2022)
Journal Article
Whittle, M. J., Bilverstone, T. W., Van Esveld, R. J., Lücke, A. C., Lister, M. M., Kuehne, S. A., & Minton, N. P. (2022). A Novel Bacteriophage with Broad Host Range against Clostridioides difficile Ribotype 078 Supports SlpA as the Likely Phage Receptor. Microbiology Spectrum, 10(1), Article e02295-21. https://doi.org/10.1128/spectrum.02295-21

Bacteriophages represent a promising option for the treatment of Clostridioides difficile (formerly Clostridium difficile) infection (CDI), which at present relies on conventional antibiotic therapy. The specificity of bacteriophages should prevent d... Read More about A Novel Bacteriophage with Broad Host Range against Clostridioides difficile Ribotype 078 Supports SlpA as the Likely Phage Receptor.