All Outputs (4054)

Measuring and optimising the efficiency of community hospital inpatient care for older people: the MoCHA mixed-methods study (2020)
Journal Article
Young, J., Hulme, C., Smith, A., Buckell, J., Godfrey, M., Holditch, C., …Thiebaud, J.-C. (2020). Measuring and optimising the efficiency of community hospital inpatient care for older people: the MoCHA mixed-methods study. Health Services and Delivery Research, 8(1), 1-99. https://doi.org/10.3310/hsdr08010

Background:
Community hospitals are small hospitals providing local inpatient and outpatient services. National surveys report that inpatient rehabilitation for older people is a core function but there are large differences in key performance meas... Read More about Measuring and optimising the efficiency of community hospital inpatient care for older people: the MoCHA mixed-methods study.

Early Responses of Brassica oleracea Roots to Zinc Supply Under Sufficient and Sub-Optimal Phosphorus Supply (2020)
Journal Article
Pongrac, P., Fischer, S., Thompson, J. A., Wright, G., & White, P. J. (2020). Early Responses of Brassica oleracea Roots to Zinc Supply Under Sufficient and Sub-Optimal Phosphorus Supply. Frontiers in Plant Science, 10, Article 1645. https://doi.org/10.3389/fpls.2019.01645

© Copyright © 2020 Pongrac, Fischer, Thompson, Wright and White. Shoot zinc (Zn) concentration in Brassica oleracea is affected by soil Zn and phosphorus (P) supply. Most problematic is the negative impact of P fertilizers on Zn concentrations in cro... Read More about Early Responses of Brassica oleracea Roots to Zinc Supply Under Sufficient and Sub-Optimal Phosphorus Supply.

Explaining the unsuitability of the kappa coefficient in the assessment and comparison of the accuracy of thematic maps obtained by image classification (2020)
Journal Article
Foody, G. M. (2020). Explaining the unsuitability of the kappa coefficient in the assessment and comparison of the accuracy of thematic maps obtained by image classification. Remote Sensing of Environment, 239, Article 111630. https://doi.org/10.1016/j.rse.2019.111630

The kappa coefficient is not an index of accuracy, indeed it is not an index of overall agreement but one of agreement beyond chance. Chance agreement is, however, irrelevant in an accuracy assessment and is anyway inappropriately modelled in the cal... Read More about Explaining the unsuitability of the kappa coefficient in the assessment and comparison of the accuracy of thematic maps obtained by image classification.

Endothelial progenitor cells, potential biomarkers for diagnosis and prognosis of ischemic stroke: protocol for an observational case-control study (2020)
Journal Article
Othman, O., Rakkar, K., Sprigg, N., Bath, P., & Bayraktutan, U. (2020). Endothelial progenitor cells, potential biomarkers for diagnosis and prognosis of ischemic stroke: protocol for an observational case-control study. Neural Regeneration Research, 15(7), 1300-1307. https://doi.org/10.4103/1673-5374.269028

Ischemic stroke is a devastating, life altering event which can severely reduce patient quality of life. Despite years of research there have been minimal therapeutic advances. Endothelial progenitor cells (EPCs), stem cells involved in both vasculog... Read More about Endothelial progenitor cells, potential biomarkers for diagnosis and prognosis of ischemic stroke: protocol for an observational case-control study.

Metallotexaphyrins as MRI-Active Catalytic Antioxidants for Neurodegenerative Disease: A Study on Alzheimer’s Disease (2020)
Journal Article
Brewster II, J. T., Thiabaud, G. D., Harvey, P., Zafar, H., Reuther, J. F., Dell'Acqua, S., …Sessler, J. L. (2020). Metallotexaphyrins as MRI-Active Catalytic Antioxidants for Neurodegenerative Disease: A Study on Alzheimer’s Disease. Chem, 6(3), 703-724. https://doi.org/10.1016/j.chempr.2019.12.016

The complex etiology of neurodegeneration continues to stifle efforts to develop effective therapeutics. New agents elucidating key pathways causing neurodegeneration might serve to increase our understanding and potentially lead to improved treatmen... Read More about Metallotexaphyrins as MRI-Active Catalytic Antioxidants for Neurodegenerative Disease: A Study on Alzheimer’s Disease.

Van der Waals SnSe2(1-x)S2x alloys: composition-dependent bowing coefficient and electron-phonon interaction (2020)
Journal Article
Kudrynskyi, Z. R., Wang, X., Sutcliffe, J., Bhuiyan, M. A., Fu, Y., Yang, Z., …Patanè, A. (2020). Van der Waals SnSe2(1-x)S2x alloys: composition-dependent bowing coefficient and electron-phonon interaction. Advanced Functional Materials, 30(9), Article 1908092. https://doi.org/10.1002/adfm.201908092

The design of advanced functional materials with customized properties often requires the use of an alloy. This approach has been used for decades, but only recently to create van der Waals (vdW) alloys for applications in electronics, optoelectronic... Read More about Van der Waals SnSe2(1-x)S2x alloys: composition-dependent bowing coefficient and electron-phonon interaction.

Exchange Rate Flexibility: How Should We Measure It? (2020)
Journal Article
Bleaney, M., & Tian, M. (2020). Exchange Rate Flexibility: How Should We Measure It?. Open Economies Review, 31(4), 881–900. https://doi.org/10.1007/s11079-019-09577-z

This paper first examines some recent exchange rate classification schemes. There is little evidence of a trend towards greater agreement between schemes. There is a probability of between 16 and 28 percent that a peg in one classification scheme is... Read More about Exchange Rate Flexibility: How Should We Measure It?.

Measuring atopic eczema symptoms in clinical practice: The first consensus statement from the Harmonising Outcome Measures for Eczema in clinical practice initiative (2020)
Journal Article
Leshem, Y. A., Chalmers, J. R., Apfelbacher, C., Furue, M., Gerbens, L. A., Prinsen, C. A., …Simpson, E. L. (2020). Measuring atopic eczema symptoms in clinical practice: The first consensus statement from the Harmonising Outcome Measures for Eczema in clinical practice initiative. Journal of The American Academy of Dermatology, 82(5), 1181-1186. https://doi.org/10.1016/j.jaad.2019.12.055

Background: Measuring patient-centered outcomes in clinical practice is valuable for monitoring patients and advancing real-world research. A new initiative from the Harmonising Outcome Measures for Eczema (HOME) group aims to recommend what might be... Read More about Measuring atopic eczema symptoms in clinical practice: The first consensus statement from the Harmonising Outcome Measures for Eczema in clinical practice initiative.

Visible‐Light‐Driven Strain‐Increase Ring Contraction Allows the Synthesis of Cyclobutyl Boronic Esters (2020)
Journal Article
Davenport, R., Silvi, M., Noble, A., Hosni, Z., Fey, N., & Aggarwal, V. K. (2020). Visible‐Light‐Driven Strain‐Increase Ring Contraction Allows the Synthesis of Cyclobutyl Boronic Esters. Angewandte Chemie International Edition, 59(16), 6525-6528. https://doi.org/10.1002/anie.201915409

There are a limited number of ring‐contraction methodologies which convert readily available five‐membered rings into strained four‐membered rings. Here we report a photo‐induced radical‐mediated ring contraction of five‐membered‐ring alkenyl boronat... Read More about Visible‐Light‐Driven Strain‐Increase Ring Contraction Allows the Synthesis of Cyclobutyl Boronic Esters.

Quantitative PA tomography of high resolution 3-D images: Experimental validation in a tissue phantom (2020)
Journal Article
Buchmann, J., Laufer, J., Kaplan, B., Prohaska, S., Powell, S., Powell, S., …Kaplan, B. (2020). Quantitative PA tomography of high resolution 3-D images: Experimental validation in a tissue phantom. Photoacoustics, 17, Article 100157. https://doi.org/10.1016/j.pacs.2019.100157

© 2019 The Author(s) Quantitative photoacoustic tomography aims to recover the spatial distribution of absolute chromophore concentrations and their ratios from deep tissue, high-resolution images. In this study, a model-based inversion scheme based... Read More about Quantitative PA tomography of high resolution 3-D images: Experimental validation in a tissue phantom.

A multiscale virtual element method for the analysis of heterogeneous media (2020)
Journal Article
Sreekumar, A., Triantafyllou, S. P., Bécot, F., & Chevillotte, F. (2020). A multiscale virtual element method for the analysis of heterogeneous media. International Journal for Numerical Methods in Engineering, 121(8), 1791-1821. https://doi.org/10.1002/nme.6287

We introduce a novel heterogeneous multiscale method for the elastic analysis of two-dimensional domains with a complex microstructure. To this end, the multiscale finite element method is revisited and originally upgraded by introducing virtual elem... Read More about A multiscale virtual element method for the analysis of heterogeneous media.

Weak Acid Resistance A (WarA), a Novel Transcription Factor Required for Regulation of Weak-Acid Resistance and Spore-Spore Heterogeneity in Aspergillus niger (2020)
Journal Article
Geoghegan, I. A., Stratford, M., Bromley, M., Archer, D. B., & Avery, S. V. (2020). Weak Acid Resistance A (WarA), a Novel Transcription Factor Required for Regulation of Weak-Acid Resistance and Spore-Spore Heterogeneity in Aspergillus niger. mSphere, 5(1), Article e00685-19. https://doi.org/10.1128/msphere.00685-19

Copyright © 2020 Geoghegan et al. Propionic, sorbic, and benzoic acids are organic weak acids that are widely used as food preservatives, where they play a critical role in preventing microbial growth. In this study, we uncovered new mechanisms of we... Read More about Weak Acid Resistance A (WarA), a Novel Transcription Factor Required for Regulation of Weak-Acid Resistance and Spore-Spore Heterogeneity in Aspergillus niger.

Randomised, double-blind, multicentre, mixed-methods, dose-escalation feasibility trial of mirtazapine for better treatment of severe breathlessness in advanced lung disease (BETTER-B feasibility) (2020)
Journal Article
Higginson, I. J., Wilcock, A., Johnson, M. J., Bajwah, S., Lovell, N., Yi, D., …Brown, S. (2020). Randomised, double-blind, multicentre, mixed-methods, dose-escalation feasibility trial of mirtazapine for better treatment of severe breathlessness in advanced lung disease (BETTER-B feasibility). Thorax, 75(2), 176-179. https://doi.org/10.1136/thoraxjnl-2019-213879

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. New treatments are required for severe breathlessness in advanced disease. We conducted a randomised feasibility trial of mirtazapine over 28 days in adults with... Read More about Randomised, double-blind, multicentre, mixed-methods, dose-escalation feasibility trial of mirtazapine for better treatment of severe breathlessness in advanced lung disease (BETTER-B feasibility).

Mortality in children and adolescents following presentation to hospital after non-fatal self-harm in the Multicentre Study of Self-harm: a prospective observational cohort study (2020)
Journal Article
Hawton, K., Bale, L., Brand, F., Townsend, E., Ness, J., Waters, K., …Geulayov, G. (2020). Mortality in children and adolescents following presentation to hospital after non-fatal self-harm in the Multicentre Study of Self-harm: a prospective observational cohort study. Lancet Child and Adolescent Health, 4(2), 111-120. https://doi.org/10.1016/S2352-4642%2819%2930373-6

© 2020 Elsevier Ltd Background: Self-harm and suicide in children and adolescents are growing problems, and self-harm is associated with a significant risk of subsequent death, particularly suicide. Long-term follow-up studies are necessary to examin... Read More about Mortality in children and adolescents following presentation to hospital after non-fatal self-harm in the Multicentre Study of Self-harm: a prospective observational cohort study.

Bayesian protein sequence and structure alignment (2020)
Journal Article
Fallaize, C. J., Green, P., Mardia, K., & Barber, S. (2020). Bayesian protein sequence and structure alignment. Journal of the Royal Statistical Society: Series C, 69(2), 301-325. https://doi.org/10.1111/rssc.12394

© 2020 Royal Statistical Society The structure of a protein is crucial in determining its functionality and is much more conserved than sequence during evolution. A key task in structural biology is to compare protein structures to determine evolutio... Read More about Bayesian protein sequence and structure alignment.

Combining EPS geofoam with geocell to reduce buried pipe loads and trench surface rutting (2020)
Journal Article
Tafreshi, S. N., Darabi, N. J., & Dawson, A. R. (2020). Combining EPS geofoam with geocell to reduce buried pipe loads and trench surface rutting. Geotextiles and Geomembranes, 48(3), 400-418. https://doi.org/10.1016/j.geotexmem.2019.12.011

© 2020 Elsevier Ltd This paper reports full scale experiments, under simulated heavy traffic, of geocell and EPS (expanded polystyrene) geofoam block inclusions to mitigate the pressure on, and deformation of, shallow buried, high density polyethylen... Read More about Combining EPS geofoam with geocell to reduce buried pipe loads and trench surface rutting.

Network analysis of human muscle adaptation to aging and contraction (2020)
Journal Article
Etheridge, T., Willis, C., Atherton, P., Ames, R., Szewczyk, N., Deane, C., …Lund, J. (2020). Network analysis of human muscle adaptation to aging and contraction. Aging, 12(1), 740-755. https://doi.org/10.18632/aging.102653

Resistance exercise (RE) remains a primary approach for minimising aging muscle decline. Understanding muscle adaptation to individual contractile components of RE (eccentric, concentric) might optimise RE-based intervention strategies. Herein, we em... Read More about Network analysis of human muscle adaptation to aging and contraction.

Overcoming technical barriers to brewing with green (non-kilned) malt: a feasibility study (2020)
Journal Article
Dugulin, C. A., Clegg, S. C., De Rouck, G., & Cook, D. J. (2020). Overcoming technical barriers to brewing with green (non-kilned) malt: a feasibility study. Journal of the Institute of Brewing, 126(1), 24-34. https://doi.org/10.1002/jib.602

Brewing using enzyme rich ‘green’ (germinated, but not kilned) malt has the potential to unlock considerable energy savings in the malting and brewing chain. This paper examines the major quality issues associated with green malt, by monitoring lipox... Read More about Overcoming technical barriers to brewing with green (non-kilned) malt: a feasibility study.

Strategic planning and place branding in a World Heritage cultural landscape: a case study of the English Lake District, UK (2020)
Journal Article
Porter, N. (2020). Strategic planning and place branding in a World Heritage cultural landscape: a case study of the English Lake District, UK. European Planning Studies, 28(7), 1291-1314. https://doi.org/10.1080/09654313.2019.1701297

What roles do strategic planning and place branding play in the context of UNESCO World Heritage Sites (WHS)? Here it is theorized that the processes associated with the nomination and management of WHS cultural landscapes involve an integration of p... Read More about Strategic planning and place branding in a World Heritage cultural landscape: a case study of the English Lake District, UK.

Microstructure and mechanical properties of fibre reinforced asphalt mixtures (2020)
Journal Article
Mohammed, M., Parry, T., Thom, N., & Grenfell, J. (2020). Microstructure and mechanical properties of fibre reinforced asphalt mixtures. Construction and Building Materials, 240, Article 117932. https://doi.org/10.1016/j.conbuildmat.2019.117932

Conventional asphalt mixtures can perform satisfactorily in most flexible pavement and airfield applications. However, during recent years the trend has been towards traffic growth, severe climate conditions, and heavier loads. This allied to durabil... Read More about Microstructure and mechanical properties of fibre reinforced asphalt mixtures.