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The adaptor protein melanophilin regulates dynamic myosin- Va: cargo interaction and dendrite development in melanocytes (2019)
Journal Article
Robinson, C. L., Evans, R. D., Sivarasa, K., Ramalho, J. S., Briggs, D. A., & Hume, A. N. (2019). The adaptor protein melanophilin regulates dynamic myosin- Va: cargo interaction and dendrite development in melanocytes. Molecular Biology of the Cell, 30(6), 731-809. https://doi.org/10.1091/mbc.E18-04-0237

Regulation of organelle transport by the cytoskeleton is fundamental for eukaryotic survival. Cytoskeleton motors are typically modular proteins with conserved motor and diverse cargo binding domains. Motor:cargo interactions are often indirect and m... Read More about The adaptor protein melanophilin regulates dynamic myosin- Va: cargo interaction and dendrite development in melanocytes.

Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses (2019)
Journal Article
Ovadia, C., Seed, P. T., Sklavounos, A., Geenes, V., Di Illio, C., Chambers, J., …Williamson, C. (2019). Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses. Lancet, 393(10174), 899-909. https://doi.org/10.1016/s0140-6736%2818%2931877-4

Background Intrahepatic cholestasis of pregnancy is associated with adverse perinatal outcomes, but the association with the concentration of specific biochemical markers is unclear. We aimed to quantify the adverse perinatal effects of intrahepatic... Read More about Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses.

The palm landscapes of the Italian Riviera (2019)
Journal Article
Piana, P., Watkins, C., & Balzaretti, R. (2019). The palm landscapes of the Italian Riviera. Landscapes, 19(1), 43-65. https://doi.org/10.1080/14662035.2019.1575112

Palm trees are today a characteristic feature of tropical tourist landscapes around the world, from the Caribbean to the Maldives. They are also a distinctive element of Mediterranean landscapes. On the Italian Riviera they are frequently found in th... Read More about The palm landscapes of the Italian Riviera.

Exploring social change through social media: the case of the Facebook group Indignant Citizens (2019)
Journal Article
Yannopoulou, N., Liu, M., Xuemei, B., & Pereira Heath, T. (2019). Exploring social change through social media: the case of the Facebook group Indignant Citizens. International Journal of Consumer Studies, 43(4), 348-357. https://doi.org/10.1111/ijcs.12514

This study examines the role of social media in facilitating the network of a social movement, the novel forms of exchange networks that are fashioned by participants of this movement and the drivers and effects of individuals' engagement therein. Sp... Read More about Exploring social change through social media: the case of the Facebook group Indignant Citizens.

Development and validation of an exome-based SNP marker set for identification of the St, Jr and Jvs genomes of Thinopyrym intermedium in a wheat background (2019)
Journal Article
Cseh, A., Yang, C., Hubbart-Edwards, S., Scholefield, D., Ashling, S. S., Burridge, A. J., …Grewal, S. (2019). Development and validation of an exome-based SNP marker set for identification of the St, Jr and Jvs genomes of Thinopyrym intermedium in a wheat background. TAG Theoretical and Applied Genetics, 132(5), 1555–1570. https://doi.org/10.1007/s00122-019-03300-9

Thinopyrum intermedium (2n = 6x = 42, StJrJvs) is one of the most promising reservoirs of useful genes including tolerance to abiotic stresses, perenniality and disease resistance not available in the cultivated bread wheat. The transfer of genetic d... Read More about Development and validation of an exome-based SNP marker set for identification of the St, Jr and Jvs genomes of Thinopyrym intermedium in a wheat background.

Revealing solvent-dependent folding behaviour of mycolic acids from Mycobacterium tuberculosis by advanced simulation analysis (2019)
Journal Article
Groenewald, W., Parra-Cruz, R. A., Jäger, C. M., & Croft, A. K. (2019). Revealing solvent-dependent folding behaviour of mycolic acids from Mycobacterium tuberculosis by advanced simulation analysis. Journal of Molecular Modeling, 25(3), Article 68. https://doi.org/10.1007/s00894-019-3943-5

Mycobacterium tuberculosis remains a persistent pathogen, partly due to its lipid rich cell wall, of which mycolic acids (MAs) are a major component. The fluidity and conformational flexibilities of different MAs in the bacterial cell wall significan... Read More about Revealing solvent-dependent folding behaviour of mycolic acids from Mycobacterium tuberculosis by advanced simulation analysis.

Revealing reionization with the thermal history of the intergalactic medium: new constrainst from the Lyα flux power spectrum (2019)
Journal Article
Boera, E., Becker, G. D., Bolton, J. S., & Nasir, F. (2019). Revealing reionization with the thermal history of the intergalactic medium: new constrainst from the Lyα flux power spectrum. Astrophysical Journal, 872(1), 1-35. https://doi.org/10.3847/1538-4357/aafee4

We present a new investigation of the thermal history of the intergalactic medium (IGM) during and after reionization using the Lyman-α forest flux power spectrum at 4.0 z 5.2. Using a sample of 15 high– resolution spectra, we measure the flux power... Read More about Revealing reionization with the thermal history of the intergalactic medium: new constrainst from the Lyα flux power spectrum.

Recombination within the Cepaea nemoralis supergene is confounded by incomplete penetrance and epistasis (2019)
Journal Article
Ramos Gonzalez, D., Aramendia, A. C., & Davison, A. (2019). Recombination within the Cepaea nemoralis supergene is confounded by incomplete penetrance and epistasis. Heredity, 123(2), 153-161. https://doi.org/10.1038/s41437-019-0190-6

Although the land snail Cepaea nemoralis is one of the most thoroughly investigated colour polymorphic species, there have been few recent studies on the inheritance of the shell traits. Previously, it has been shown that the shell polymorphism is co... Read More about Recombination within the Cepaea nemoralis supergene is confounded by incomplete penetrance and epistasis.

‘The different sets of ideas at the back of our heads’: Dissent and authority at the International Court of Justice (2019)
Journal Article
Mistry, H. (2019). ‘The different sets of ideas at the back of our heads’: Dissent and authority at the International Court of Justice. Leiden Journal of International Law, 32(2), 293-313. https://doi.org/10.1017/S0922156519000049

© 2019 Foundation of the Leiden Journal of International Law. Additional opinions (AOs) - dissenting opinions, separate opinions and declarations, whether authored individually or jointly - are a distinctive characteristic of the ICJ's jurisprudence.... Read More about ‘The different sets of ideas at the back of our heads’: Dissent and authority at the International Court of Justice.

tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis (2019)
Journal Article
Savage, A. M., Kurusamy, S., Chen, Y., Jiang, Z., Chhabria, K., MacDonald, R. B., …Wilkinson, R. N. (2019). tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis. Nature Communications, 10, Article 732. https://doi.org/10.1038/s41467-019-08590-7

Angiogenesis requires co-ordination of multiple signalling inputs to regulate the behaviour of endothelial cells (ECs) as they form vascular networks. Vascular endothelial growth factor (VEGF) is essential for angiogenesis and induces downstream sign... Read More about tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis.

Cultural Protest in Journalism, Documentary Films and the Arts: Between Protest and Professionalisation (2019)
Book
Mutibwa, D. H. (2019). Cultural Protest in Journalism, Documentary Films and the Arts: Between Protest and Professionalisation. London: Routledge

Cultural Protest in Journalism, Documentary Films and the Arts: Between Protest and Professionalisation entails a comprehensive account of the history and trajectory of contemporary journalistic, (documentary) film, and arts and cultural actors roote... Read More about Cultural Protest in Journalism, Documentary Films and the Arts: Between Protest and Professionalisation.

Anaesthetist-controlled versus patient-maintained effect-site targeted propofol sedation during elective primary lower-limb arthroplasty performed under spinal anaesthesia (ACCEPTS): study protocol for a parallel-group randomised comparison trial (2019)
Journal Article
Hewson, D. W., Worcester, F., Sprinks, J., Smith, M. D., Buchanan, H., Breedon, P., …Bedforth, N. M. (2019). Anaesthetist-controlled versus patient-maintained effect-site targeted propofol sedation during elective primary lower-limb arthroplasty performed under spinal anaesthesia (ACCEPTS): study protocol for a parallel-group randomised comparison trial. Trials, 20(1), Article 129. https://doi.org/10.1186/s13063-019-3228-4

Background The clinical efficacy of effect-site targeted patient-maintained propofol sedation (PMPS) compared to anaesthetist-controlled propofol sedation (ACPS) for patients undergoing awake joint replacement surgery is currently unknown. There is... Read More about Anaesthetist-controlled versus patient-maintained effect-site targeted propofol sedation during elective primary lower-limb arthroplasty performed under spinal anaesthesia (ACCEPTS): study protocol for a parallel-group randomised comparison trial.

Tactical authenticity in the production of mad narratives (2019)
Journal Article
WRIGHT, C., & CLARKE, S. (2019). Tactical authenticity in the production of mad narratives. Social Theory and Health, 17(2), 15. https://doi.org/10.1057/s41285-019-00092-2

First-person accounts of madness and of encountering psychiatric services provide important sociocultural and psychological knowledge about the subjectivity of distress. The importance of such accounts is often based upon a claim of the authenticity... Read More about Tactical authenticity in the production of mad narratives.

Insight into imiquimod skin permeation and increased delivery using microneedle pre-treatment (2019)
Journal Article
Al-Mayahy, M. H., Sabri, A. H., Rutland, C. S., Holmes, A., McKenna, J., Marlow, M., & Scurr, D. J. (2019). Insight into imiquimod skin permeation and increased delivery using microneedle pre-treatment. European Journal of Pharmaceutics and Biopharmaceutics, 139, 33-43. https://doi.org/10.1016/j.ejpb.2019.02.006

Basal cell carcinoma (BCC) is the most common skin cancer in humans. Topical treatment with imiquimod provides a non-invasive, self-administered treatment with relatively low treatment cost. Despite displaying excellent efficacy, imiquimod is only li... Read More about Insight into imiquimod skin permeation and increased delivery using microneedle pre-treatment.

Gsmodutils: a python based framework for test-driven genome scale metabolic model development (2019)
Journal Article
Gilbert, J., Pearcy, N., Norman, R., Millat, T., Winzer, K., King, J., …Twycross, J. (2019). Gsmodutils: a python based framework for test-driven genome scale metabolic model development. Bioinformatics, 35(18), 3397-3403. https://doi.org/10.1093/bioinformatics/btz088

© 2019 The Author(s) 2019. Published by Oxford University Press. Motivation: Genome scale metabolic models (GSMMs) are increasingly important for systems biology and metabolic engineering research as they are capable of simulating complex steady-stat... Read More about Gsmodutils: a python based framework for test-driven genome scale metabolic model development.

1-Hydroxy-xanthine derivatives inhibit the human Caf1 nuclease and Caf1-containing nuclease complexes via Mg2+-dependent binding (2019)
Journal Article
Airhihen, B., Pavanello, L., Jadhav, G. P., Fischer, P. M., & Winkler, G. S. (2019). 1-Hydroxy-xanthine derivatives inhibit the human Caf1 nuclease and Caf1-containing nuclease complexes via Mg2+-dependent binding. FEBS Open Bio, 9(4), 717-727. https://doi.org/10.1002/2211-5463.12605

In eukaryotic cells, cytoplasmic mRNA is characterised by a 3’ poly(A) tail. The shortening and removal of poly(A) tails (deadenylation) by the Ccr4‐Not nuclease complex leads to reduced translational efficiency and RNA degradation. Using recombinant... Read More about 1-Hydroxy-xanthine derivatives inhibit the human Caf1 nuclease and Caf1-containing nuclease complexes via Mg2+-dependent binding.

Interaction of nutrition and genetics via DNMT3L-mediated DNA methylation determines cognitive decline (2019)
Journal Article
Flitton, M., Rielly, N., Warman, R., Warden, D., Smith, A. D., Macdonald, I. A., & Knight, H. M. (2019). Interaction of nutrition and genetics via DNMT3L-mediated DNA methylation determines cognitive decline. Neurobiology of Aging, 78, 64-73. https://doi.org/10.1016/j.neurobiolaging.2019.02.001

Low homocysteine levels and B vitamin treatment are reported to protect against declining cognitive health. Both B vitamins and homocysteine are involved in the production of S-adenosylmethionine, a universal methyl donor essential for the process of... Read More about Interaction of nutrition and genetics via DNMT3L-mediated DNA methylation determines cognitive decline.

SDSS IV MaNGA: full spectroscopic bulge-disc decomposition of MaNGA early-type galaxies (2019)
Journal Article
Tabor, M., Merrifield, M., Aragón-Salamanca, A., Fraser-Mckelvie, A., Peterken, T., Smethurst, R., …Lane, R. R. (2019). SDSS IV MaNGA: full spectroscopic bulge-disc decomposition of MaNGA early-type galaxies. Monthly Notices of the Royal Astronomical Society, 485(2), 1546–1558. https://doi.org/10.1093/mnras/stz431

By applying spectroscopic decomposition methods to a sample of MaNGA early-type galaxies, we separate out spatially and kinematically distinct stellar populations, allowing us to explore the similarities and differences between galaxy bulges and disc... Read More about SDSS IV MaNGA: full spectroscopic bulge-disc decomposition of MaNGA early-type galaxies.

G protein-coupled receptors are dynamic regulators of digestion and targets for digestive diseases (2019)
Journal Article
Canals, M., Poole, D. P., Veldhuis, N. A., Schmidt, B. L., & Bunnett, N. W. (2019). G protein-coupled receptors are dynamic regulators of digestion and targets for digestive diseases. Gastroenterology, 156(6), 1600-1616. https://doi.org/10.1053/j.gastro.2019.01.266

G protein-coupled receptors (GPCRs) are the largest family of transmembrane signaling proteins. Within the gastrointestinal tract, GPCRs expressed by epithelial cells sense contents of the lumen, and GPCRs expressed by epithelial cells, myocytes, neu... Read More about G protein-coupled receptors are dynamic regulators of digestion and targets for digestive diseases.