All Outputs (4613)

Thick drops climbing uphill on an oscillating substrate (2018)
Journal Article
Bradshaw, J., & Billingham, J. (2018). Thick drops climbing uphill on an oscillating substrate. Journal of Fluid Mechanics, 840, https://doi.org/10.1017/jfm.2018.71

Experiments have shown that a liquid droplet on an inclined plane can be made to move uphill by suffciently strong, vertical oscillations (Brunet, Eggers, and Deegan, Phys. Rev. Lett. 99, 2007). In this paper, we study a two dimensional, inviscid, ir... Read More about Thick drops climbing uphill on an oscillating substrate.

Phase II, open-label, randomized, multicenter trial (HERBY) of Bevacizumab in pediatric patients with newly diagnosed high-grade glioma (2018)
Journal Article
Grill, J., Massimino, M., Bouffet, E., Azizi, A. A., McCowage, G., Cañete, A., …Giangaspero, F. (2018). Phase II, open-label, randomized, multicenter trial (HERBY) of Bevacizumab in pediatric patients with newly diagnosed high-grade glioma. Journal of Clinical Oncology, 36(10), https://doi.org/10.1200/JCO.2017.76.0611

Purpose
Bevacizumab (BEV) is approved in more than 60 countries for use in adults with recurrent glioblastoma. We evaluated the addition of BEV to radiotherapy plus temozolomide (RT+TMZ) in pediatric patients with newly diagnosed high-grade glioma (... Read More about Phase II, open-label, randomized, multicenter trial (HERBY) of Bevacizumab in pediatric patients with newly diagnosed high-grade glioma.

A candidate tolerance gene identified in a natural population of field voles (Microtus agrestis) (2018)
Journal Article
Wanelik, K. M., Begon, M., Birtles, R. J., Bradley, J. E., Friberg, I. M., Jackson, J. A., …Paterson, S. (in press). A candidate tolerance gene identified in a natural population of field voles (Microtus agrestis). Molecular Ecology, 27(4), https://doi.org/10.1111/mec.14476

The animal immune response has hitherto been viewed primarily in the context of resistance only. However, individuals can also employ a tolerance strategy to maintain good health in the face of ongoing infection. To shed light on the genetic and phys... Read More about A candidate tolerance gene identified in a natural population of field voles (Microtus agrestis).

Evaluation of sampling frequency, window size and sensor position for classification of sheep behaviour (2018)
Journal Article
Walton, E., Casey, C., Mitsch, J., Vázquez-Diosdado, J. A., Yan, J., Dottorini, T., …Kaler, J. (2018). Evaluation of sampling frequency, window size and sensor position for classification of sheep behaviour. Royal Society Open Science, 5(2), https://doi.org/10.1098/rsos.171442

Automated behavioural classification and identification through sensors has the potential to improve health and welfare of the animals. Position of a sensor, sampling frequency and window size of segmented signal data has a major impact on classifica... Read More about Evaluation of sampling frequency, window size and sensor position for classification of sheep behaviour.

Sustenance and performance: nutritional reserves, longevity and contest outcomes of fed and starved adult parasitoid wasps (2018)
Journal Article
Snart, C. J., Kapranas, A., Williams, H., Barrett, D. A., & Hardy, I. C. (2018). Sustenance and performance: nutritional reserves, longevity and contest outcomes of fed and starved adult parasitoid wasps. Frontiers in Ecology and Evolution, https://doi.org/10.3389/fevo.2018.00012

Dyadic contests for possession of resources occur across a wide range of animal taxa, with contest outcome often being heavily influenced by the energetic reserves of the competitors. The majority of studied parasitoid wasps lack de novo lipogenesis,... Read More about Sustenance and performance: nutritional reserves, longevity and contest outcomes of fed and starved adult parasitoid wasps.

A physical activity intervention for children with type 1 diabetes: Steps to Active Kids with Diabetes (STAK-D): a feasibility study (2018)
Journal Article
Quirk, H., Glazebrook, C., & Blake, H. (in press). A physical activity intervention for children with type 1 diabetes: Steps to Active Kids with Diabetes (STAK-D): a feasibility study. BMC Pediatrics, 18, https://doi.org/10.1186/s12887-018-1036-8

Background: This study describes the development and feasibility evaluation of a physical activity intervention for children with type 1 diabetes called ‘Steps to Active Kids with Diabetes’ (STAK-D). It aims to explore the feasibility and acceptabili... Read More about A physical activity intervention for children with type 1 diabetes: Steps to Active Kids with Diabetes (STAK-D): a feasibility study.

Enhanced detection services for developmental dysplasia of the hip in Scottish children 1997-2013 (2018)
Journal Article
McAllister, D. A., Morling, J. R., Fischbacher, C., Reidy, M., Murray, A., & Wood, R. (2018). Enhanced detection services for developmental dysplasia of the hip in Scottish children 1997-2013. Archives of Disease in Childhood, 103(11), 1021-1026. https://doi.org/10.1136/archdischild-2017-314354

Background

Developmental dysplasia of the hip (DDH) remains common. If detected early, DDH can usually be corrected with conservative management. Late presentations often require surgery, and have worse outcomes.

Objective

We estimated th... Read More about Enhanced detection services for developmental dysplasia of the hip in Scottish children 1997-2013.

Synthesis of orchestrations of transducers for manufacturing (2018)
Presentation / Conference Contribution
De Giacomo, G., Vardi, M. Y., Felli, P., Alechina, N., & Logan, B. (2018). Synthesis of orchestrations of transducers for manufacturing.

In this paper, we model manufacturing processes and facilities as transducers (automata with output). The problem of whether a given manufacturing process can be realized by a given set of manufacturing resources can then be stated as an orchestratio... Read More about Synthesis of orchestrations of transducers for manufacturing.

Educating for a systems design approach to complex societal problems (2018)
Journal Article
Costa Junior, J. D., Diehl, J. C., & Secomandi, F. (2018). Educating for a systems design approach to complex societal problems. Journal of Engineering Design, 29(3), https://doi.org/10.1080/09544828.2018.1436162

Design education has devoted little attention to the topic of societal systems transformation in the context of sustainable development. This paper reports on a master‘s-level course that aims to build the capacity for design engineering students to... Read More about Educating for a systems design approach to complex societal problems.

Cutting Materials in Half: A Graph Theory Approach for Generating Crystal Surfaces and Its Prediction of 2D Zeolites (2018)
Journal Article
Witman, M., Ling, S., Boyd, P., Barthel, S., Haranczyk, M., Slater, B., & Smit, B. (2018). Cutting Materials in Half: A Graph Theory Approach for Generating Crystal Surfaces and Its Prediction of 2D Zeolites. ACS Central Science, 4(2), 235-245. https://doi.org/10.1021/acscentsci.7b00555

© 2018 American Chemical Society. Scientific interest in two-dimensional (2D) materials, ranging from graphene and other single layer materials to atomically thin crystals, is quickly increasing for a large variety of technological applications. Whil... Read More about Cutting Materials in Half: A Graph Theory Approach for Generating Crystal Surfaces and Its Prediction of 2D Zeolites.

The enhancement of rapidly quenched galaxies in distant clusters at 0.5 < z < 1.0 (2018)
Journal Article
Socolovsky, M., Almaini, O., Hatch, N. A., Wild, V., Maltby, D. T., Hartley, W. G., & Simpson, C. (2018). The enhancement of rapidly quenched galaxies in distant clusters at 0.5 < z < 1.0. Monthly Notices of the Royal Astronomical Society, 476(1), https://doi.org/10.1093/mnras/sty312

We investigate the relationship between environment and galaxy evolution in the redshift range $0.5<z<1.0$. Galaxy overdensities are selected using a Friends-of-Friends algorithm, applied to deep photometric data in the Ultra-Deep Survey (UDS) field...

Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease (2018)
Journal Article
Sargeant, J. A., Bawden, S., Aithal, G. P., Simpson, E. J., Macdonald, I. A., Turner, M. C., …King, J. A. (2018). Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease. European Journal of Applied Physiology, 118(4), 817-828. https://doi.org/10.1007/s00421-018-3818-y

Purpose: This study examined the feasibility of sprint interval exercise training (SIT) for men with non-alcoholic fatty liver disease (NAFLD) and its effects on intrahepatic triglyceride (IHTG), insulin sensitivity (hepatic and peripheral), visceral... Read More about Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease.

Exposure to the ROCK inhibitor fasudil promotes gliogenesis of neural stem cells in vitro (2018)
Journal Article
Nizamudeen, Z. A., Chakrabarti, L., & Sottile, V. (2018). Exposure to the ROCK inhibitor fasudil promotes gliogenesis of neural stem cells in vitro. Stem Cell Research, 28, 75-86. https://doi.org/10.1016/j.scr.2018.02.001

Fasudil is a clinically approved Rho-associated protein kinase (ROCK) inhibitor that has been used widely to treat cerebral consequences of subarachnoid haemorrhage. It is known to have a positive effect on animal models of neurological disorders inc... Read More about Exposure to the ROCK inhibitor fasudil promotes gliogenesis of neural stem cells in vitro.

Dry-powder formulations of non-covalent protein complexes with linear or miktoarm copolymers for pulmonary delivery (2018)
Journal Article
Nieto-Orellana, A., Coghlan, D., Rothery, M., Falcone, F. H., Bosquillon, C., Childerhouse, N., Mantovani, G., & Stolnik, S. (2018). Dry-powder formulations of non-covalent protein complexes with linear or miktoarm copolymers for pulmonary delivery. International Journal of Pharmaceutics, 540(1-2), https://doi.org/10.1016/j.ijpharm.2018.02.008

Pulmonary delivery of protein therapeutics has considerable clinical potential for treating both local and systemic diseases. However, poor protein conformational stability, immunogenicity and protein degradation by proteolytic enzymes in the lung ar... Read More about Dry-powder formulations of non-covalent protein complexes with linear or miktoarm copolymers for pulmonary delivery.

Multifunctional serine protease inhibitor-coated water-soluble gold nanoparticles as a novel targeted approach for the treatment of inflammatory skin diseases (2018)
Journal Article
Limón, D., Fábrega, M. J., Calpena, A. C., Badia, J., Baldomà, L., & Pérez-García, L. (2018). Multifunctional serine protease inhibitor-coated water-soluble gold nanoparticles as a novel targeted approach for the treatment of inflammatory skin diseases. Bioconjugate Chemistry, 28(4), https://doi.org/10.1021/acs.bioconjchem.7b00717

The overexpression and increased activity of the serine protease Kallikrein 5 (KLK5) is characteristic of inflammatory skin diseases such as Rosacea. The use of inhibitors of this enzyme—such as 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride... Read More about Multifunctional serine protease inhibitor-coated water-soluble gold nanoparticles as a novel targeted approach for the treatment of inflammatory skin diseases.

Suboptimal acclimation of photosynthesis to light in wheat canopies (2018)
Journal Article
Townsend, A. J., Retkute, R., Chinnathambi, K., Randall, J. W., Foulkes, J. F., Carmo-Silva, E., & Murchie, E. H. (in press). Suboptimal acclimation of photosynthesis to light in wheat canopies. Plant Physiology, 176(2), https://doi.org/10.1104/pp.17.01213

Photosynthetic acclimation (photoacclimation) is the process whereby leaves alter their morphology and/or biochemistry to optimise photosynthetic efficiency and productivity according to long-term changes in the light environment. Three-dimensional (... Read More about Suboptimal acclimation of photosynthesis to light in wheat canopies.

Heterologous expression of a novel drug transporter from the malaria parasite alters resistance to quinoline antimalarials (2018)
Journal Article
Tindall, S. M., Vallières, C., Lakhani, D. H., Islahudin, F., Ting, K.-N., & Avery, S. V. (in press). Heterologous expression of a novel drug transporter from the malaria parasite alters resistance to quinoline antimalarials. Scientific Reports, 8(1), https://doi.org/10.1038/s41598-018-20816-0

Antimalarial drug resistance hampers effective malaria treatment. Critical SNPs in a particular, putative amino acid transporter were recently linked to chloroquine (CQ) resistance in malaria parasites. Here, we show that this conserved protein (PF3D... Read More about Heterologous expression of a novel drug transporter from the malaria parasite alters resistance to quinoline antimalarials.

Microstructure and wear behaviour of powder and suspension hybrid Al2O3–YSZ coatings (2018)
Journal Article
Murray, J. W., Leva, A., Joshi, S., & Hussain, T. (in press). Microstructure and wear behaviour of powder and suspension hybrid Al2O3–YSZ coatings. Ceramics International, https://doi.org/10.1016/j.ceramint.2018.02.048

Suspension based plasma sprayed coatings can yield superior microstructural and tribological properties compared to conventional powder based plasma sprayed coatings. This study investigates a new hybrid method, using simultaneous spraying from powde... Read More about Microstructure and wear behaviour of powder and suspension hybrid Al2O3–YSZ coatings.

John Stuart Mill and Fourierism: ‘association’, ‘friendly rivalry’ and distributive justice (2018)
Journal Article
McCabe, H. (2018). John Stuart Mill and Fourierism: ‘association’, ‘friendly rivalry’ and distributive justice. Global Intellectual History, 4(1), 35-61. https://doi.org/10.1080/23801883.2018.1435983

John Stuart Mill’s self-description as ‘under the general designation of Socialist’ has been under-explored. It is an important feature of something else often overlooked: the importance of the French context of Mill’s thought. This article focuses... Read More about John Stuart Mill and Fourierism: ‘association’, ‘friendly rivalry’ and distributive justice.

Assessment of time-dependent density functional theory with the restricted excitation space approximation for excited state calculations of large systems (2018)
Journal Article
Hanson-Heine, M. W., George, M. W., & Besley, N. A. (in press). Assessment of time-dependent density functional theory with the restricted excitation space approximation for excited state calculations of large systems. Molecular Physics, 116(11), https://doi.org/10.1080/00268976.2018.1430388

The restricted excitation subspace approximation is explored as a basis to reduce the memory storage required in linear response time-dependent density functional theory (TDDFT) calculations within the Tamm-Dancoff approximation. It is shown that exc... Read More about Assessment of time-dependent density functional theory with the restricted excitation space approximation for excited state calculations of large systems.