Long-term exposure to irinotecan reduces cell migration in glioma cells.

Al-Ghafari, Ayat B.; Punjaruk, Wiyada; Storer, L.C.D.; Carrier, D.J.; Hussein, D.; Coyle, Beth; Kerr, Ian D.

doi:10.1007/s11060-016-2058-4

All Outputs (4330)

Probing deeper into the risks of slips, trips and falls for an ageing rail passenger population: applying a systems approach (2016)
Journal Article
Waterson, P. E., Kendrick, V. L., Ryan, B., Jun, T., & Haslam, R. A. (2016). Probing deeper into the risks of slips, trips and falls for an ageing rail passenger population: applying a systems approach. IET Intelligent Transport Systems, 10(1), 25-31. https://doi.org/10.1049/iet-its.2015.0047

In this study, the authors report the findings from a study of the contributory factors leading to slips, trips and falls (STFs) amongst elderly passengers at train stations and how these are likely to change in the future over the medium to long ter... Read More about Probing deeper into the risks of slips, trips and falls for an ageing rail passenger population: applying a systems approach.

Challenging school reform from below: is leadership the missing link in mobilization theory? (2016)
Journal Article
Stevenson, H. (2016). Challenging school reform from below: is leadership the missing link in mobilization theory?. Leadership and Policy in Schools, 15(1), 67-90. https://doi.org/10.1080/15700763.2015.1071403

This article presents research relating to the experiences of union and community-based campaigns that have sought to challenge the establishment of academy and free schools in England. Such schools are removed from local government control and are s... Read More about Challenging school reform from below: is leadership the missing link in mobilization theory?.

Comparing the cost-effectiveness and clinical effectiveness of a new community in-reach rehabilitation service with the cost-effectiveness and clinical effectiveness of an established hospital-based rehabilitation service for older people: a pragmatic randomised controlled trial with microcost and qualitative analysis – the Community In-reach Rehabilitation And Care Transition (CIRACT) study (2016)
Journal Article
Sahota, O., Pulikottil-Jacob, R., Marshall, F., Montgomery, A., Tan, W., Sach, T., …Waring, J. (2016). Comparing the cost-effectiveness and clinical effectiveness of a new community in-reach rehabilitation service with the cost-effectiveness and clinical effectiveness of an established hospital-based rehabilitation service for older people: a pragmatic randomised controlled trial with microcost and qualitative analysis – the Community In-reach Rehabilitation And Care Transition (CIRACT) study. Health Services and Delivery Research, 4(7), https://doi.org/10.3310/hsdr04070

Background:
Older people represent a significant proportion of patients admitted to hospital as a medical emergency. Compared with the care of younger patients, their care is more challenging, their stay in hospital is much longer, their risk of ho... Read More about Comparing the cost-effectiveness and clinical effectiveness of a new community in-reach rehabilitation service with the cost-effectiveness and clinical effectiveness of an established hospital-based rehabilitation service for older people: a pragmatic randomised controlled trial with microcost and qualitative analysis – the Community In-reach Rehabilitation And Care Transition (CIRACT) study.

Railway infrastructure asset management: the whole-system life cost analysis (2016)
Journal Article
Rama, D., & Andrews, J. D. (2016). Railway infrastructure asset management: the whole-system life cost analysis. IET Intelligent Transport Systems, 10(1), https://doi.org/10.1049/iet-its.2015.0030

Delivering the railway infrastructure whose functionality is sustainable and uncompromised in terms of safety and availability under ever decreasing budget constraints is a great challenge. The successful accomplishment of this task relies on the eff... Read More about Railway infrastructure asset management: the whole-system life cost analysis.

The just meaningful difference in speech-to-noise ratio (2016)
Journal Article
McShefferty, D., Whitmer, W. M., & Akeroyd, M. A. (2016). The just meaningful difference in speech-to-noise ratio. Trends in Hearing, 20, https://doi.org/10.1177/2331216515626570

The speech-to-noise ratio (SNR) in an environment plays a vital role in speech communication for both normal-hearing (NH) and hearing-impaired (HI) listeners. While hearing-assistance devices attempt to deliver as favorable an SNR as possible, there... Read More about The just meaningful difference in speech-to-noise ratio.

Performance evaluation of turbulence-accentuated interchannel crosstalk for hybrid fibre and free-space optical wavelength-division-multiplexing systems using digital pulse-position modulation (2016)
Journal Article
Mbah, A. M., Walker, J. G., & Phillips, A. J. (2016). Performance evaluation of turbulence-accentuated interchannel crosstalk for hybrid fibre and free-space optical wavelength-division-multiplexing systems using digital pulse-position modulation. IET Optoelectronics, 10(1), https://doi.org/10.1049/iet-opt.2015.0007

A hybrid fibre and free-space optical communication link using digital pulse-position modulation (DPPM) in a wavelength-division-multiplexing system is proposed. Such a system, which could provide a power efficient, robust and flexible solution to hi... Read More about Performance evaluation of turbulence-accentuated interchannel crosstalk for hybrid fibre and free-space optical wavelength-division-multiplexing systems using digital pulse-position modulation.

Rigorous morality: norms, values, and the comparative politics of human rights (2016)
Journal Article
Landman, T. (2016). Rigorous morality: norms, values, and the comparative politics of human rights. Human Rights Quarterly, 38(1), https://doi.org/10.1353/hrq.2016.0014

This paper argues that there is a strong role for empirical analysis to be used to address fundamental normative questions. Using human rights as an example, the article shows that the evolution of the international regime of human rights provides a... Read More about Rigorous morality: norms, values, and the comparative politics of human rights.

Simulation of failure of air plasma sprayed thermal barrier coating due to interfacial and bulk cracks using surface-based cohesive interaction and extended finite element method (2016)
Journal Article
Kyaw, S., Jones, I., & Hyde, T. (2016). Simulation of failure of air plasma sprayed thermal barrier coating due to interfacial and bulk cracks using surface-based cohesive interaction and extended finite element method. Journal of Strain Analysis for Engineering Design, 51(2), https://doi.org/10.1177/0309324715615746

The present paper describes a method of predicting the failure of a thermal barrier coating system due to interfacial cracks and cracks within bulk coatings. The interfacial crack is modelled by applying cohesive interfaces where the thermally grown... Read More about Simulation of failure of air plasma sprayed thermal barrier coating due to interfacial and bulk cracks using surface-based cohesive interaction and extended finite element method.

Rates of self-harm presenting to general hospitals: a comparison of data from the Multicentre Study of Self-Harm in England and Hospital Episode Statistics (2016)
Journal Article
Clements, C., Turnbull, P., Hawton, K., Geulayov, G., Waters, K., Ness, J., …Kapur, N. (2016). Rates of self-harm presenting to general hospitals: a comparison of data from the Multicentre Study of Self-Harm in England and Hospital Episode Statistics. BMJ Open, 6, Article e009749. https://doi.org/10.1136/bmjopen-2015-009749

Objective: Rates of hospital presentation for self-harm in England were compared using different national and local data sources.

Design: The study was descriptive and compared bespoke data collection methods for recording self-harm presentations... Read More about Rates of self-harm presenting to general hospitals: a comparison of data from the Multicentre Study of Self-Harm in England and Hospital Episode Statistics.

School leadership and management in South Africa: findings from a systematic literature review (2016)
Journal Article
Bush, T., & Glover, D. (2016). School leadership and management in South Africa: findings from a systematic literature review. International Journal of Educational Management, 30(2), https://doi.org/10.1108/IJEM-07-2014-0101

Purpose: The purpose of this paper is to provide a systematic review of the literature on school leadership and management in South Africa, linked to the 20th anniversary of democratic government and integrated education.
Design/methodology/approach... Read More about School leadership and management in South Africa: findings from a systematic literature review.

The use of nutritional supplements in dressage and eventing horses (2016)
Journal Article
Agar, C., Gemmill, R., Hollands, T., & Freeman, S. (2016). The use of nutritional supplements in dressage and eventing horses. Veterinary Record Open, 3(1), Article e000154. https://doi.org/10.1136/vetreco-2015-000154

The aim of the study was to determine which types of nutritional supplements were used in dressage and eventing horses, and the reasons that owners used supplements. An online questionnaire was distributed through British Eventing and Dressage websit... Read More about The use of nutritional supplements in dressage and eventing horses.

Measuring loss aversion under ambiguity: a method to make prospect theory completely observable (2016)
Journal Article
Abdellaoui, M., Bleichrodt, H., l'Haridon, O., & van Dolder, D. (2016). Measuring loss aversion under ambiguity: a method to make prospect theory completely observable. Journal of Risk and Uncertainty, 52(1), 1-20. https://doi.org/10.1007/s11166-016-9234-y

We propose a simple, parameter-free method that, for the first time, makes it possible to completely observe Tversky and Kahneman’s (1992) prospect theory. While methods exist to measure event weighting and the utility for gains and losses separately... Read More about Measuring loss aversion under ambiguity: a method to make prospect theory completely observable.

England and Wales: Empirical Findings (2016)
Book Chapter
Kemp, V., & Hodgson, J. (2016). England and Wales: Empirical Findings. In M. Vanderhallen, M. V. Oosterhout, M. Panzavolta, & D. D. Vocht (Eds.), Interrogating young suspects: procedural safeguards from an empirical perspective. Intersentia

Pilot study of long-term anaesthesia in broiler chickens (2016)
Journal Article
O'Kane, P. M., Connerton, I. F., & White, K. L. (2016). Pilot study of long-term anaesthesia in broiler chickens. Veterinary Anaesthesia and Analgesia, 43(1), 72-75. https://doi.org/10.1111/vaa.12305

Objective: To provide stable anaesthesia of long duration in broiler chickens in order to perform a terminal caecal ligated loop procedure.

Study design: Prospective experimental study.

Animals: Seven clinically healthy broiler chickens (Gallus... Read More about Pilot study of long-term anaesthesia in broiler chickens.

Prognostic factors for long-term outcomes in relapsing–remitting multiple sclerosis (2016)
Journal Article
Traboulsee, A. L., Cornelisse, P., Sandberg-Wollheim, M., Uitdehaag, B. M., Kappos, L., Jongen, P. J., …Li, D. K. (2016). Prognostic factors for long-term outcomes in relapsing–remitting multiple sclerosis. Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2, https://doi.org/10.1177/2055217316666406

Objective: The objective of this article is to investigate potential clinical and MRI predictors of long-term outcomes in multiple sclerosis (MS).

Methods: This was a post hoc analysis using data from all 382 patients in the PRISMS long-term foll... Read More about Prognostic factors for long-term outcomes in relapsing–remitting multiple sclerosis.

Vocationalism varies (a lot): a 12-country multivariate analysis of participation in formal adult learning (2016)
Journal Article
Boeren, E., & Holford, J. (2016). Vocationalism varies (a lot): a 12-country multivariate analysis of participation in formal adult learning. Adult Education Quarterly, 66(2), 120-142. https://doi.org/10.1177/0741713615624207

To encourage adult participation in education and training, contemporary policy makers typically encourage education and training provision to have a strongly vocational (employment-related) character, while also stressing individuals’ responsibility... Read More about Vocationalism varies (a lot): a 12-country multivariate analysis of participation in formal adult learning.

The limits of anticolonialism: the British Labour movement and the end of the empire in Guiana (2016)
Journal Article
Mawby, S. (2016). The limits of anticolonialism: the British Labour movement and the end of the empire in Guiana. History, 101(344), 84-106. https://doi.org/10.1111/1468-229X.12156

The Labour Party’s ambivalent attitude to anticolonial nationalism is well known but its place in the conflicts between the party’s revisionists and the left has been less fully elaborated, while the influence of British trade unions in the formation... Read More about The limits of anticolonialism: the British Labour movement and the end of the empire in Guiana.

Workers in the vanguard: the 1960 Industrial Relations Ordinance and the struggle for independence in Aden (2016)
Journal Article
Mawby, S. (2016). Workers in the vanguard: the 1960 Industrial Relations Ordinance and the struggle for independence in Aden. Labor History, 57(1), 35-52. https://doi.org/10.1080/0023656X.2016.1140622

The promulgation in 1960 of a new Industrial Relations Ordinance in Aden was a singular event in the history of British decolonisation because it made many forms of strike action illegal. Earlier initiatives to liberalise trade union law in the colon... Read More about Workers in the vanguard: the 1960 Industrial Relations Ordinance and the struggle for independence in Aden.

The Typology of the Berlin Block: History, Continuity and Spatial Performance (2016)
Journal Article

Long-term exposure to irinotecan reduces cell migration in glioma cells. (2016)
Journal Article
Al-Ghafari, A. B., Punjaruk, W., Storer, L., Carrier, D., Hussein, D., Coyle, B., & Kerr, I. D. (2016). Long-term exposure to irinotecan reduces cell migration in glioma cells. Journal of Neuro-Oncology, 127(3), 455-462. https://doi.org/10.1007/s11060-016-2058-4

In spite of considerable research into the therapies for glioblastoma multiforme this tumour type remains very difficult to treat. As well as having a tendency to be inherently resistant to chemotherapy, glioblastoma multiforme also displays local in... Read More about Long-term exposure to irinotecan reduces cell migration in glioma cells..