Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions

Drinkwater, Nyssa; Vinh, Natalie B.; Mistry, Shailesh N.; Bamert, Rebecca S.; Ruggeri, Chiara; Holleran, John P.; Loganathan, Sasdekumar; Paiardini, Alessandro; Charman, Susan A.; Powell, Andrew K.; Avery, Vicky M.; McGowan, Sheena; Scammells, Peter J.

doi:10.1016/j.ejmech.2016.01.015

All Outputs (4338)

An innovative framework for probabilistic-based structural assessment with an application to existing reinforced concrete structures (2016)
Journal Article
Matos, J. C., Cruz, P. J., Valente, I. B., Neves, L. C., & Moreira, V. N. (2016). An innovative framework for probabilistic-based structural assessment with an application to existing reinforced concrete structures. Engineering Structures, 111, https://doi.org/10.1016/j.engstruct.2015.12.040

A novel framework for probabilistic-based structural assessment of existing structures, which combines model identification and reliability assessment procedures, considering in an objective way different sources of uncertainty, is presented in this... Read More about An innovative framework for probabilistic-based structural assessment with an application to existing reinforced concrete structures.

Electrical switching of an antiferromagnet (2016)
Journal Article
Wadley, P., Howells, B., Železný, J., Andrews, C., Hills, V., Campion, R. P., …Jungwirth, T. (2016). Electrical switching of an antiferromagnet. Science, 351(6273), 587-590. https://doi.org/10.1126/science.aab1031

Antiferromagnets are hard to control by external magnetic fields because of the alternating directions of magnetic moments on individual atoms and the resulting zero net magnetization. However, relativistic quantum mechanics allows for generating cur... Read More about Electrical switching of an antiferromagnet.

Guidelines for reporting embedded recruitment trials (2016)
Journal Article
Madurasinghe, V. W., Eldridge, S., & Forbes, G. (in press). Guidelines for reporting embedded recruitment trials. Trials, 17, https://doi.org/10.1186/s13063-015-1126-y

Background: Recruitment to clinical trials is difficult with many trials failing to recruit to target and within time. Embedding trials of recruitment interventions within host trials may provide a successful way to improve this. There are no guidel... Read More about Guidelines for reporting embedded recruitment trials.

Encouraging serendipity in research: designing technologies to support connection-making (2016)
Journal Article
Kefalidou, G., & Sharples, S. (in press). Encouraging serendipity in research: designing technologies to support connection-making. International Journal of Human-Computer Studies, 89, https://doi.org/10.1016/j.ijhcs.2016.01.003

Mobile applications have the ability to present information to users that is influenced by their surroundings, activities and interests. Such applications have the potential to influence the likelihood of individuals experiencing ‘serendipity’, throu... Read More about Encouraging serendipity in research: designing technologies to support connection-making.

3D Printing of Biocompatible Supramolecular Polymers and their Composites (2016)
Journal Article
Hart, L. R., Li, S., Sturgess, C., Wildman, R. D., Jones, J. R., & Hayes, W. (in press). 3D Printing of Biocompatible Supramolecular Polymers and their Composites. ACS Applied Materials and Interfaces, 8(5), https://doi.org/10.1021/acsami.5b10471

A series of polymers capable of self-assembling into infinite networks via supramolecular interactions have been designed, synthesized, and characterized for use in 3D printing applications. The biocompatible polymers and their composites with silica... Read More about 3D Printing of Biocompatible Supramolecular Polymers and their Composites.

A mature galaxy cluster at z= 1.58 around the radio galaxy 7C 1753+6311 (2016)
Journal Article
Cooke, E. A., Hatch, N. A., Stern, D., Rettura, A., Brodwin, M., Galametz, A., …Jarvis, M. (2016). A mature galaxy cluster at z= 1.58 around the radio galaxy 7C 1753+6311. Astrophysical Journal, 816(2), Article 83. https://doi.org/10.3847/0004-637X/816/2/83

We report on the discovery of a z = 1.58 mature cluster around the high-redshift radio galaxy 7C 1753+6311, first identified in the Clusters Around Radio-loud active galactic nuclei survey. Two-thirds of the excess galaxies within the central 1 Mpc l... Read More about A mature galaxy cluster at z= 1.58 around the radio galaxy 7C 1753+6311.

Links between depressive symptoms and unmet health and social care needs among older prisoners (2016)
Journal Article
O'Hara, K., Forsyth, K., Webb, R., Senior, J., Hayes, A. J., Challis, D., …Shaw, J. (2016). Links between depressive symptoms and unmet health and social care needs among older prisoners. Age and Ageing, 45(1), 158-163. https://doi.org/10.1093/ageing/afv171

© The Author 2016. Background: absolute numbers of older prisoners and their proportion of the total prison population are increasing. They have multiple health and social care needs that are prominent on entry into prison. No previous studies have i... Read More about Links between depressive symptoms and unmet health and social care needs among older prisoners.

A systematic review of interventions to reduce hospitalisation in Parkinson's disease (2016)
Journal Article
Muzerengi, S., Herd, C., Rick, C., & Clarke, C. (2016). A systematic review of interventions to reduce hospitalisation in Parkinson's disease. Parkinsonism and Related Disorders, 24, 3-7. https://doi.org/10.1016/j.parkreldis.2016.01.011

The neurodegenerative process in Parkinson's disease (PD) results in a relentless progression of motor and non-motor symptoms. Affected individuals are frequently hospitalised for complications of the disease including falls, fractures, infections, a... Read More about A systematic review of interventions to reduce hospitalisation in Parkinson's disease.

Development of a curriculum for advanced nurse practitioners working with older people with frailty in the acute hospital through a modified Delphi process (2016)
Journal Article
Goldberg, S. E., Cooper, J., Blundell, A., Gordon, A. L., Masud, T., & Moorchilot, R. (2016). Development of a curriculum for advanced nurse practitioners working with older people with frailty in the acute hospital through a modified Delphi process. Age and Ageing, 45(1), 48-53. https://doi.org/10.1093/ageing/afv178

Background: advanced nurse practitioners (ANPs) are experienced nurses who undertake some activities traditionally performed by medical staff. There are four pillars of advanced practice: advanced clinical skills, leadership, education and research.... Read More about Development of a curriculum for advanced nurse practitioners working with older people with frailty in the acute hospital through a modified Delphi process.

The facilitators of communication with people with dementia in a care setting: an interview study with healthcare workers (2016)
Journal Article
Stanyon, M. R., Griffiths, A., Thomas, S. A., & Gordon, A. L. (2016). The facilitators of communication with people with dementia in a care setting: an interview study with healthcare workers. Age and Ageing, 45(1), 164-170. https://doi.org/10.1093/ageing/afv161

Objectives: to describe the views of healthcare workers on the facilitators of communication with people with dementia in a care setting.
Design: thematic analysis of semi-structured interviews.
Setting: all participants were interviewed in their p... Read More about The facilitators of communication with people with dementia in a care setting: an interview study with healthcare workers.

Electron localisation function in current-density-functional theory (2016)
Journal Article
Furness, J. W., Ekström, U., Helgaker, T., & Teale, A. M. (2016). Electron localisation function in current-density-functional theory. Molecular Physics, 114(7-8), 1415-1422. https://doi.org/10.1080/00268976.2015.1133859

We present a generalisation of the electron localisation function (ELF) to current-density-functional theory as a descriptor for the properties of molecules in the presence of magnetic fields. The resulting current ELF (cELF) is examined for a range... Read More about Electron localisation function in current-density-functional theory.

Thecal cell sensitivity to luteinizing hormone and insulin in polycystic ovarian syndrome (2016)
Journal Article
Cadagan, D., Khan, R., & Amer, S. A. (2016). Thecal cell sensitivity to luteinizing hormone and insulin in polycystic ovarian syndrome. Reproductive Biology -Olsztyn-, 16(1), https://doi.org/10.1016/j.repbio.2015.12.006

This study examined whether a defect of steroid synthesis in ovarian theca cells may lead to the development of PCOS, through contributions to excess androgen secretion.

Polycystic ovarian syndrome (PCOS) is one of the leading causes of infertilit... Read More about Thecal cell sensitivity to luteinizing hormone and insulin in polycystic ovarian syndrome.

A novel method for metal–diamond composite coating deposition with cold spray and formation mechanism (2016)
Journal Article
Aldwell, B., Yin, S., McDonnell, K. A., Trimble, D., Hussain, T., & Lupoi, R. (2016). A novel method for metal–diamond composite coating deposition with cold spray and formation mechanism. Scripta Materialia, 115, https://doi.org/10.1016/j.scriptamat.2015.12.028

This paper describes the application of cold spray to the deposition of a diamond grade pre-coated with Cu and Ni. This is the first time that pre-coated diamond powders are used as the sole feedstock without the addition of binders (ductile phases)... Read More about A novel method for metal–diamond composite coating deposition with cold spray and formation mechanism.

Cascaded regression with sparsified feature covariance matrix for facial landmark detection (2016)
Journal Article
Sánchez Lozano, E., Martinez, B., & Valstar, M. F. (2016). Cascaded regression with sparsified feature covariance matrix for facial landmark detection. Pattern Recognition Letters, 73, 19-25. https://doi.org/10.1016/j.patrec.2015.11.014

This paper explores the use of context on regression-based methods for facial landmarking. Regression based methods have revolutionised facial landmarking solutions. In particular those that implicitly infer the whole shape of a structured object hav... Read More about Cascaded regression with sparsified feature covariance matrix for facial landmark detection.

The NHS Health Check in England: an evaluation of the first 4 years (2016)
Journal Article
Robson, J., Dostal, I., Sheikh, A., Eldridge, S., Madurasinghe, V., Griffiths, C., …Hippisley-Cox, J. (2016). The NHS Health Check in England: an evaluation of the first 4 years. BMJ Open, 6(1), Article e008840. https://doi.org/10.1136/bmjopen-2015-008840

Objectives: To describe implementation of a new national preventive programme to reduce cardiovascular morbidity.

Design: Observational study over 4 years (April 2009—March 2013).

Setting: 655 general practices across England from the QResear... Read More about The NHS Health Check in England: an evaluation of the first 4 years.

Genome-wide methylation analysis identifies genes silenced in non-seminoma cell lines (2016)
Journal Article
Noor, D. A. M., Jeyapalan, J. N., Alhazmi, S., Carr, M., Squibb, B., Wallace, C., …Scotting, P. J. (2016). Genome-wide methylation analysis identifies genes silenced in non-seminoma cell lines. npj Genomic Medicine, 1(15009), https://doi.org/10.1038/npjgenmed.2015.9

Silencing of genes by DNA methylation is a common phenomenon in many types of cancer. However, the genome wide effect of DNA methylation on gene expression has been analysed in relatively few cancers. Germ cell tumours (GCTs) are a complex group of m... Read More about Genome-wide methylation analysis identifies genes silenced in non-seminoma cell lines.

Do crab spiders perceive Batesian mimicry in hoverflies? (2016)
Journal Article
Morris, R. L., & Reader, T. (2016). Do crab spiders perceive Batesian mimicry in hoverflies?. Behavioral Ecology, 27(3), 920-931. https://doi.org/10.1093/beheco/arv233

© 2015 The Author. Many putative Batesian mimics only approximately resemble their supposed models, and such "imperfect" mimics are readily distinguished from defended species by humans and other vertebrates. One explanation for the existence of impe... Read More about Do crab spiders perceive Batesian mimicry in hoverflies?.

Detection of UWB ranging measurement quality for collaborative indoor positioning (2016)
Journal Article
Jing, H., Bonenberg, L. K., Pinchin, J., Hill, C., & Moore, T. (in press). Detection of UWB ranging measurement quality for collaborative indoor positioning. Journal of Location Based Services, 9(4), https://doi.org/10.1080/17489725.2015.1120359

Wireless communication signals have become popular alternatives for indoor positioning and navigation due to lack of navigation satellite signals in such environments. The signal characteristics determine the method used for positioning as well as th... Read More about Detection of UWB ranging measurement quality for collaborative indoor positioning.

A Bayesian approach to analyzing phenotype microarray data enables estimation of microbial growth parameters (2016)
Journal Article
Gerstgrasser, M., Nicholls, S., Stout, M., Smart, K., Powell, C., Kypraios, T., & Stekel, D. J. (2016). A Bayesian approach to analyzing phenotype microarray data enables estimation of microbial growth parameters. Journal of Bioinformatics and Computational Biology, 14(03), 1-23. https://doi.org/10.1142/S0219720016500074

Biolog phenotype microarrays enable simultaneous, high throughput analysis of cell cultures in different environments. The output is high-density time-course data showing redox curves (approximating growth) for each experimental condition. The softwa... Read More about A Bayesian approach to analyzing phenotype microarray data enables estimation of microbial growth parameters.

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions (2016)
Journal Article
Drinkwater, N., Vinh, N. B., Mistry, S. N., Bamert, R. S., Ruggeri, C., Holleran, J. P., …Scammells, P. J. (2016). Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. European Journal of Medicinal Chemistry, 110, 43-64. https://doi.org/10.1016/j.ejmech.2016.01.015

© 2016 Elsevier Masson SAS. Malaria remains a global health problem, and though international efforts for treatment and eradication have made some headway, the emergence of drug-resistant parasites threatens this progress. Antimalarial therapeutics a... Read More about Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions.